Clinical trials: High Cardiovascular Risk
Cardiovascular Risk Factor
Comparison of Electronic Cigarettes and Tobacco Cigarettes on Cardiovascular Function and Oxidative Stress
Background: Electronic cigarettes (e-cigarettes) are battery-powered devices heating a liquid (e-liquid) composed of propylene glycol and/or vegetable glycerin, and most commonly, nicotine to form an aerosol (vapor) that is…
- Trial name
- NCT03036644
- Testing
- e-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature)
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Atherosclerosis and Blood Flow in Coronary Artery
Geometrical Influences on Atherosclerosis and Blood Flow
The study investigates the use of advanced imaging techniques and computational methods to identify high-risk plaques in coronary arteries.
- Trial name
- NCT07002697
- Where
- Bangladesh
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Engineering and Technology
Cardiovascular Risk Factor, Cardiovascular Diseases
The DEtermining Statin Intolerance FOr Rosuvastatin (DESIFOR) Trial
This study will enroll patients who previously were not able to tolerate being on a statin medication due to muscle-related side effects.
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Adverse Effect
- Trial name
- DESIFOR (NCT03889314)
- Testing
- Rosuvastatin 20mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
Hypertriglyceridemia
Effects Of Consumption Of A Highly Mineralized Sodium Bicarbonated Water On Blood Lipid Profile
The aim of the study is to assess the beneficial effect of the short term consumption of the highly mineralized bicarbonated sodium water on blood lipid parameters compared to a low mineralized water.
- Trial name
- NCT01819636
- Testing
- sparkling highly mineral bicarbonated sodium water
- Where
- 3 sites in France
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Neptune
Cardiovascular Risk Factor, Obesity
Essential Amino Acids and High Intensity Interval Training
Purpose: The primary purpose is to determine the combined effects of essential amino acids (EAA) supplementation and high intensity interval training (HIIT) on body composition, muscle characteristics, and muscle architecture in…
- Trial name
- NCT04080102
- Testing
- High Intensity Interval Training, Essential Amino Acid, High intensity interval training and essential amino acid supplement
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Disease, Metabolic Syndrome X
Inflammatory Profiles of Children at High Risk for Atherosclerosis
The purpose of this study is to evaluate levels of inflammatory mediators in children at risk for cardiovascular disease due to family history.
- Conditions
- Cardiovascular Disease, Metabolic Syndrome X, Hypercholesterolemia, Inflammation
- Trial name
- NCT00115232
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Obesity
High Fat Diet: Oxidative and Cardiovascular Effects
To test the effects of a modified Atkins high fat diet on endothelial function, insulin resistance and energy balance.
- Trial name
- AFN (NCT00696228)
- Testing
- MUFA, PUFA, SFA
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Healthy Participants With Moderate and High Cardiovascular Risk
Aspirin Withdrawal and Clinical Outcome in Patients With Moderate to High Cardiovascular Risk But Without Cardiovascular Disease
While the efficacy of aspirin for the secondary prevention of cardiovascular disease is evident, the effect of aspirin for primary prevention is unclear.
- Trial name
- NCT03757156
- Testing
- Withdrawal of aspirin
- Where
- South Korea
- Volunteers
- 4,118 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Cardiovascular Disease, Chronic Kidney Disease Patients
A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients
The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodialytic Patients, High LDL Level
- Trial name
- L5 (NCT01236820)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Blood Pressure, High, Cardiovascular Risk Factor
Efficacy of a Brief Intervention on Reduction of Systolic Blood Pressure
This study examines the efficacy of individualized counseling letters to reduce systolic blood pressure level of ≥ 130 mmHg in individuals aged between 40 and 65 years.
- Trial name
- NCT03077373
- Testing
- Counseling letter
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Cardiovascular Disease
A Study Examining Effects of Apples/ Apple Products on Heart Disease Risk
This study will examine if health benefits of consuming nutrient-rich apples, an apple extract and freeze dried apple product will be similar.
- Trial name
- APPS (NCT01585519)
- Testing
- High/ Low Epicatechin Apples/ Apple Extract/ Granules
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Arthritis Knee, Spine Fusion
Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery
The present study is a multi-center randomized prospective non-inferiority trial. The study's primary objective is to compare the coagulation profile upon using two different TXA administration strategies: empirical TXA…
- Conditions
- Arthritis Knee, Spine Fusion, Prostate Cancer, Arthritis of Hip
- Trial name
- NCT05957822
- Testing
- TXA, TEG6
- Where
- South Korea
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Heart Failure
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
This study is a prospective, multi-center, pivotal trial to study the safety and efficacy of the WiSE-CRT System for Cardiac Re-synchronization Therapy.
- Trial name
- SOLVE-CRT (NCT02922036)
- Testing
- WiSE System
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- EBR Systems, Inc.
Hypertension, Health Behavior
Nourish: A Digital Health Program to Promote the DASH Eating Plan Among Adults With High Blood Pressure
The goal of Nourish is to help adults with high blood pressure enjoy an eating pattern called DASH (Dietary Approaches to Stop Hypertension) to lower blood pressure and improve health.
- Trial name
- NCT03875768
- Testing
- Tracking plus coaching
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Duke University
Lifestyle Risk Reduction, Cholesterol, Elevated
Effect of a Customised Lifestyle Medicine Strategy on Lowering Blood Lipid Levels in Indian Physicians
Lifestyle medicine is a medical specialty that uses evidence-based therapeutic interventions to prevent, treat, and reverse chronic conditions.
- Conditions
- Lifestyle Risk Reduction, Cholesterol, Elevated, LDL Hyperlipoproteinemia, Hypertension
- Trial name
- CLIP (NCT06420817)
- Testing
- Indian version of a 'Portfolio' diet, Physical Activity, Intermittent fasting
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
Healthy Volunteers, Insulin Resistance
Polyphenols and Insulin Resistance
Diet and nutrition play an essential role in the development and the clinical expression of the most common health problems. Overeating and obesity induce oxidative stress, which has been proposed to be a pathogenic mechanism…
- Conditions
- Healthy Volunteers, Insulin Resistance, Type 2 Diabetes (T2D)
- Trial name
- POLYOXRESIST (NCT01478841)
- Testing
- polyphenol
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cardiovascular Risk Factor
The Salty Gut: Effects of High Dietary Salt Intake on the Gut Microbiota
Gut microbiota has a role in cardiovascular disease and recent findings in rodents show dietary salt can negatively alter gut microbiota composition. High salt intake is a risk factor for cardiovascular disease.
- Trial name
- NCT04229680
- Testing
- High Salt, Recommended Salt
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Endothelial Function, Aerobic Exercise
VascuFit: Exercise and Vascular Aging
Exercise is a cornerstone of health care helping to improve and maintain a good organ functionality, including vascular function, in health and disease.
- Conditions
- Endothelial Function, Aerobic Exercise, Middle-aged Adults Sedentary, Elevated CV-risk)
- Trial name
- VascuFit (NCT05235958)
- Testing
- non-linear periodized exercise (NLPE), Exercise counselling
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Karsten Königstein
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Cardiovascular Diseases, Metabolic Syndrome
Effect of Dried Fruit on Cardiometabolic Risk Factors
This is a 2-period randomized crossover study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of ¾ cup of a blend of dried plums, figs, dates and raisins (DPFDR) with an…
- Trial name
- NCT03020758
- Testing
- Dried Fruit, High Carbohydrate Snack
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Penn State University