Clinical trials: High Cardiovascular Risk
Cardiovascular Risk Factor
Enhanced Vascular Function Following Intake of Feruloyl Esterase-processed High Fibre Bread.
This study evaluates the impact of a high phenolic acid intake from wholegrain wheat bread on human vascular function and plasma phenolic acid concentrations in healthy adults.
- Trial name
- NCT03946293
- Testing
- White Bread, Wholegrain bread, Wholegrain Enzyme
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Reading
Obesity
Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk Factors
Web- or internet-based programs have the potential to induce and, possibly, help to sustain, significant lifestyle modification.
- Trial name
- NCT01472276
- Testing
- Web-based program
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Physical Activity, Life Style
Cardiovascular Disease Prevention Strategies for High-risk Urban Sedentary Employees in Karachi, Pakistan
Heart diseases and other non-communicable diseases are serious health issues in countries like Pakistan. Many people who work in offices, like bank employees, sit for more than 8 hours a day.
- Conditions
- Physical Activity, Life Style, Dietary Habits, Cardiovascular Diseases
- Trial name
- m-LIfE (NCT06981247)
- Testing
- m-LIfE: mobile based lifestyle intervention for employees to increase their physical activity and promote healthy diet., Routine care arm
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Cardiovascular Risk
Precision Study of CLAiR AI Software
This multi-site precision study evaluated the performance and reproducibility of the CLAiR artificial intelligence (AI) software in identifying elevated risk of atherosclerotic cardiovascular disease (ASCVD) from retinal fundus…
- Trial name
- NCT07747233
- Testing
- CLAiR Artificial Intelligence Software
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Toku Eyes Ltd
Obesity, Visceral, Cardiovascular Diseases
Impact of Liraglutide 3.0 on Body Fat Distribution
This study is a clinical study to investigate the efficacy of liraglutide compared to placebo in reducing visceral adiposity measured by MRI in overweight or obese subjects at high risk for cardiovascular disease after 40 weeks…
- Conditions
- Obesity, Visceral, Cardiovascular Diseases, Fat Disorder
- Trial name
- NCT03038620
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Insulin Resistance, Hypertriglyceridemia
Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.
Approximately 1/4 of the US population has insulin resistance and the associated risk factors such as elevated lipid levels -triglycerides (type of fat from what we eat and what the liver produces and low HDL cholesterol which is…
- Trial name
- NCT00186537
- Testing
- Rosiglitazone, Fenofibrate, Weight Loss
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cardiometabolic Risk Factors, Diabetes
Delta GREENS Food is Medicine Intervention
Mississippi is a place deeply rooted in cultural values, yet also a place where generations of communities have experienced persistent health challenges intertwined with poverty.
- Conditions
- Cardiometabolic Risk Factors, Diabetes, High Blood Pressure, Obesity
- Trial name
- NCT06358859
- Testing
- Food is Medicine
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tufts University
Overweight and Obesity, Healthy
The Impact of High-Fat Ketogenic Diet and Low-Fat Diet in Women Body Weight
The aim of this study is investigated the effect of high fat Ketogenic Diet (HFKD) in weight reduction compared to the low-fat diet (LFD) among Saudi overweight and obese women.
- Trial name
- NCT05811702
- Testing
- A randomized acute controlled trial of twenty-eight healthy overweight or obese women
- Where
- Saudi Arabia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- King Faisal University
Cardiovascular Disease
A Study Examining Effects of Apples/ Apple Products on Heart Disease Risk
This study will examine if health benefits of consuming nutrient-rich apples, an apple extract and freeze dried apple product will be similar.
- Trial name
- APPS (NCT01585519)
- Testing
- High/ Low Epicatechin Apples/ Apple Extract/ Granules
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Acute Coronary Syndrome
TnThs for Identification Myocardial Infarction
OBJECTIVES/BACKGROUND: We sought to determine the early diagnostic value of the new high sensitive cardiac troponin T assay (TnThs) in suspected acute coronary syndrome (ACS) and to compare it with the 4th generation cTnT assay…
- Trial name
- NCT00950469
- Where
- Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Coronary Artery Disease, Early-Onset
HIIT Versus IMT on Modulating Blood Rheology in CAD Risk Factors
Participants had randomly divided into two equal groups. Group (A) had received a program of high intensity interval training 30-40 minutes three times per week for one month.
- Trial name
- NCT03506984
- Testing
- Threshold Inspiration Muscle Training Device, Electronic Bicycle Ergometer
- Where
- Oman
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypertension
Effects of the DASH vs. the Mediterranean Diet Combined With Salt Restriction on Blood Pressure Levels in Adults
Non-pharmacological measures should serve as the first-line treatment in individuals with high normal blood pressure (BP) levels or grade 1 hypertension and low-moderate cardiovascular disease risk.
- Trial name
- NCT05669404
- Testing
- Salt Restriction Group (SRG), DASH Diet combined with salt restriction Group (DDG), Mediterranean Diet combined with salt restriction Group (MDG)
- Where
- Greece
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hippocration General Hospital
Insulin Resistance, Cardiovascular Disease
Processing Responses of Grains (PRO-Grains) Study
The primary objective of this pilot study will be to examine the effects of consuming whole grains, differing in the degree of processing, on insulin sensitivity and other cardiometabolic risk factors.
- Conditions
- Insulin Resistance, Cardiovascular Disease, Diabetes
- Trial name
- NCT02186353
- Testing
- Partial feeding study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hypertension
A Cluster-Randomized Trial of a Hypertension Risk Model-Based Precision Intervention in High-Risk Adults in Shunyi District
This community cluster-randomized controlled trial aims to evaluate the effectiveness of a hypertension risk model-based precision intervention among adults at high risk of developing hypertension in Shunyi District, Beijing…
- Trial name
- NCT07804420
- Testing
- Hypertension Risk Model-Based Precision Intervention, Standard Health Education
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University
Thromboses, Venous, Lower Limb Injury
A Prospective Study to Assess the Risk Factors That Contribute to Thrombosis in Patients With Lower Limb Injuries.
This study is aimed at identifying patients at high risk for Venous Thrombo-Embolism (VTE) (clots in the veins of legs or clots in the lungs) who have lower limb injuries treated with immobilisation of the lower limb.
- Trial name
- TILLIRI (NCT04608591)
- Where
- Ireland
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Cardiovascular Diseases, Metabolic Syndrome
Effect of Dried Fruit on Cardiometabolic Risk Factors
This is a 2-period randomized crossover study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of ¾ cup of a blend of dried plums, figs, dates and raisins (DPFDR) with an…
- Trial name
- NCT03020758
- Testing
- Dried Fruit, High Carbohydrate Snack
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases
Elucidating the High Cardiovascular Disease Risk in South Asians
The goals of this cross-sectional study are to compare immune cell composition and release of incretin hormones following a meal in healthy Dutch South Asians and Dutch Europids.
- Trial name
- CAMI (NCT05829018)
- Testing
- Mixed meal test
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hypertension, Cardiovascular Risk Factor
HIGH Altitude CArdiovascular REsearch Latin America Population Study
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude Sickness
- Trial name
- HIGHCARE-LAPS (NCT04751292)
- Testing
- Exposure to high altitude
- Where
- Peru
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Overweight, Obesity
Glycemic Load, Weight Loss and Cardiovascular Disease Risk
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors.
- Trial name
- NCT00254215
- Testing
- high protein & low glycemic index diets
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Hypertriglyceridemia
Docosahexenoic Acid (DHA) Supplementation and Cardiovascular Disease in Men With High Triglycerides
The purpose of this study is to determine the effects of supplementing diets of hyperlipidemic men with DHA (docosahexenoic acid) on risk factors for cardiovascular disease.
- Trial name
- NCT00728338
- Testing
- Docosahexenoic acid (DHA), Olive oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center