Clinical trials: High Cardiovascular Risk
Cardiovascular Diseases
The Usefulness of the HyperQ Stress System in Routine Annual Screening Testing
The main objective of this study is to compare the sensitivity and specificity of a new system for analyzing the electrocardiogram (ECG) to the sensitivity and specificity of a conservative treadmill test in asymptomatic…
- Trial name
- NCT00266435
- Where
- Israel
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Blood Pressure, High, Cardiovascular Risk Factor
Efficacy of a Brief Intervention on Reduction of Systolic Blood Pressure
This study examines the efficacy of individualized counseling letters to reduce systolic blood pressure level of ≥ 130 mmHg in individuals aged between 40 and 65 years.
- Trial name
- NCT03077373
- Testing
- Counseling letter
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Diabetes Mellitus, Type 2
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and…
- Trial name
- NCT00520962
- Where
- Italy
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes Type 2
Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes
This study was set up to assess the effects of different doses of aspirin when compared with placebo (dummy drug), used sequentially over a 2 week study period with a 2 week wash-out (rest period) in between, in people with…
- Trial name
- NCT00898950
- Testing
- Aspirin
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Cardiovascular Diseases, Primary Prevention
Proactive Cardiovascular Prevention Strategy in Subjects With High Genetic Risk
A polygenic risk score (PRS) will be developed and implemented into the primary care digital work-flow. 1000 study subjects with no known cardiovascular disease, diabetes or statin treatment and with high PRS (men of 30-65, women…
- Trial name
- EstPerMedCV (NCT04291157)
- Testing
- CVD risk estimation incorporating the PRS and guideline based preventive interventions., Standard GP care
- Where
- 2 sites in Estonia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Alar Irs
Atrophy
Effect of Exercise on Risk-factors of Elderly Women
The purpose of this study is to determine whether exercise training may impact relevant risk factors and health costs of community living women older 65 years.
- Trial name
- NCT00267839
- Testing
- physical exercise, wellness
- Where
- 2 sites in Germany
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cardiovascular Disease
mHealth Interventions to Improve Access and Coverage of Uninsured People With High Cardiovascular Risk in Argentina.
Cardiovascular disease (CVD) accounts for approximately one-third of Argentina's deaths. Despite the availability of management and treatment for CVD which is offered to the uninsured population at government primary care clinics…
- Trial name
- mHealth (NCT02913339)
- Testing
- mHealth Risk Assessment
- Where
- Argentina
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Alcohols, Cardiovascular Diseases
Postprandial Effect of Chinese Tea Flavor Liquor on Selected CVD Risk Factors
Background: human studies of Chinese liquor are sparse. we hypothesis that Chinese Tea Flavor liquor may be beneficial to CVD risk factors postprandially.
- Trial name
- TFL (NCT01264666)
- Testing
- Chinese tea flavor liquor, Chinese Meijiao liquor, Water control
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Pregnancy, High Risk, Pre-Eclampsia
Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Raised blood pressure is a common problem in pregnancy. Raised blood pressure and pre-eclampsia affect about one in ten women and are a major cause of death and premature birth in the United Kingdom and worldwide.
- Conditions
- Pregnancy, High Risk, Pre-Eclampsia, Hypertension, Hypertension, Pregnancy-Induced
- Trial name
- BUMP (NCT03334149)
- Testing
- Self-Monitoring of Blood Pressure
- Where
- 13 sites in United Kingdom
- Volunteers
- 3,042 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Coronary Artery Disease, Angina Pectoris
Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using Optical Coherence Tomography(OCT)[LINK IT TWO]
This study aim is to evaluate the additional effect of eicosapentaenoic acid and dose up effect of rosuvastatin for neoatherosclerosis in coronary artery disease patients.
- Trial name
- NCT03657758
- Testing
- EPA and rosuvastatin, High dose rosuvastatin
- Where
- Japan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kobe University
Vascular Diseases, Hypercholesterolemia
The Effect of Plant Sterols on the Blood Lipid Profile of Subjects With and at High Risk of Type 2 Diabetes Mellitus
Double-blind, randomised, placebo-controlled, parallel group study with two intervention arms. The study will be conducted in 150 subjects and the primary objective is to show a fasting LDL-cholesterol and triglyceride lowering…
- Conditions
- Vascular Diseases, Hypercholesterolemia, Diabetes Mellitus
- Trial name
- NCT02288585
- Testing
- Plant sterols
- Where
- 2 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Heart of the Family: A Cardiovascular Disease and Type 2 Diabetes Risk Reduction Intervention in High-Risk Rural Families
Rural populations in the U.S. are disproportionately burdened by cardiovascular disease and type 2 diabetes. Lifestyle modification interventions are needed that support long-term engagement in risk-reducing health behaviors.
- Trial name
- NCT04891575
- Testing
- Active Control Intervention educational sessions, Family Dyad Intervention
- Where
- United States
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Gia Mudd
Hypertension, Vitamin D Deficiency
DAYLIGHT: Vitamin D Therapy in Individuals at High Risk of Hypertension
This is a randomized, double-blind, multicenter, 6-month follow-up trial of low (400 IU/day) versus high (4000 IU/day) dose vitamin D supplementation in individuals with pre- and early stage 1 hypertension and vitamin D…
- Conditions
- Hypertension, Vitamin D Deficiency, Pre-Hypertension
- Trial name
- DAYLIGHT (NCT01240512)
- Testing
- Cholecalciferol
- Where
- 3 sites in United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertension
Study of the Impact of Low Fat Dairy and High Fat Dairy Consumption on Daytime Ambulatory Blood Pressure
Market trends depicted by Agriculture and Agri-Food Canada suggest stagnation in cheese consumption, with potentially important impact on this key industry in Canada.
- Trial name
- GABA2 (NCT02763930)
- Testing
- Control diet, Milk diet, GABA-rich cheese diet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiovascular Risk Factor
The Salty Gut: Effects of High Dietary Salt Intake on the Gut Microbiota
Gut microbiota has a role in cardiovascular disease and recent findings in rodents show dietary salt can negatively alter gut microbiota composition. High salt intake is a risk factor for cardiovascular disease.
- Trial name
- NCT04229680
- Testing
- High Salt, Recommended Salt
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cardiovascular Disease
Effect of Fruit and Vegetables on Insulin Resistance
Current evidence indicates that fruit and vegetable intake and dietary patterns rich in fruit and vegetables may be associated with reduced insulin resistance and may reduce the risk of the metabolic syndrome.
- Trial name
- FIRST (NCT00874341)
- Testing
- Fruit and vegetable intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Obstructive Sleep Apnea, Pregnancy Induced Hypertension
Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes
Hypothesis:Sleep Disorders are very common during pregnancy but the their exact role in causation of pregnancy related disorders is yet to be determined.
- Conditions
- Obstructive Sleep Apnea, Pregnancy Induced Hypertension, High-Risk Pregnancy, Restless Leg Syndrome
- Trial name
- NCT02016638
- Testing
- Polysomnography and ambulatory blood pressure recording
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Hypercholesterolemia, Cardiovascular Diseases
Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol
The Bean Study will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol.
- Trial name
- NCT03830970
- Testing
- Canned beans of multiple varieties, White Rice
- Where
- 2 sites in Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast