Clinical trials: High Flow Nasal Cannula, open to volunteers
Airway Disorder
Optimizing High Flow Nasal Cannula Oxygenation in Pediatric Airway Procedures
The purpose of this study is to investigate which flow rate (higher versus lower) is most effective at increasing apneic time and preventing greater than 5% drop in desaturation, as well as assessing transcutaneous carbon dioxide…
- Trial name
- NCT06947902
- Testing
- High flow, Low Flow
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Respiratory Acidosis
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.
- Trial name
- NCT06970002
- Testing
- Use of NIV during FOB as a respiratory support method, Use of HFNC during FOB as a respiratory support method
- Volunteers
- 210 people
- Sponsor
- Medical University of Silesia
Postoperative Atelectasis, Postoperative Pulmonary Complications
HFNC for Postoperative Atelectasis After Laparoscopic Surgery
Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative…
- Trial name
- NCT07676760
- Testing
- High-Flow Nasal Cannula (HFNC), Conventional Oxygen Therapy
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
Postoperative Complications, Atelectasis
High-Flow Nasal Cannula After Major Abdominal Surgery to Prevent Postoperative Pulmonary Complications
Major abdominal surgery is associated with a substantial risk of early postoperative pulmonary complications, including atelectasis, hypoxemia, pneumonia, and increased need for respiratory support.
- Conditions
- Postoperative Complications, Atelectasis, Pneumonia, Respiratory Insufficiency
- Trial name
- NCT07528404
- Testing
- High flow nasal cannula (HFNC), Standard oxygen therapy
- Where
- South Korea
- Volunteers
- 580 people
- Sponsor
- Uijeongbu St. Mary Hospital
Obstructive Sleep Apnea (OSA)
CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior…
- Trial name
- CHOSA (NCT07600333)
- Testing
- High Flow Nasal Cannula, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 258 people
- Sponsor
- The Hospital for Sick Children
Premature Infant, Ventilation Therapy
High Flow Nasal Cannula for Stabilization of Extremely Premature Infants
A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth.
- Conditions
- Premature Infant, Ventilation Therapy, High Flow Nasal Canula
- Trial name
- SIMPLSAFE2 (NCT06683677)
- Testing
- High-Flow Nasal Cannula
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Respiratory Failure
ROX Index Versus MROX Index to Predict Treatment Outcome for High Flow Nasal Cannula And/or Noninvasive Ventilation in Patients with Respiratory Failure
One of managing steps in respiratory failure is high flow nasal cannula (HFNC), but the exact time to turn to invasive machine ventilation (IMV) is necessarily being determined.
- Trial name
- NCT06715644
- Volunteers
- 120 people
- Sponsor
- Assiut University
Respiratory Failure, Heart Rate Variability (HRV)
Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy
High-flow nasal cannula is a type of non-invasive respiratory support that helps patients breathe more comfortably. Because the flow is high, it can deliver more oxygen to the lungs and make breathing easier by reducing the…
- Conditions
- Respiratory Failure, Heart Rate Variability (HRV), High Flow Nasal Cannula
- Trial name
- VARIATION (NCT07518862)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Bronchiectasis
HFNC in Management of Bronchiectasis Exacerbation
Patients with Bronchiectasis experience exacerbations with hypercapnic respiratory failure associated with an increased respiratory workload that may require intensive care unit (ICU) admission due to the inability of the…
- Trial name
- NCT05741697
- Testing
- bi-level ventillation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Burn Injury, Hypoxia
Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation
Burn-related pain is severe and often difficult to manage. Burn patients often require high doses of opioids and anxiolytics. Anesthetic agents used during sedation such as benzodiazepines, propofol and opioids can cause…
- Conditions
- Burn Injury, Hypoxia, Sedation
- Trial name
- NCT06756906
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Cirrhosis, Polyps of Colon
Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients
High flow nasal cannula oxygenation (HFNC) offers high flow and concentration oxygen delivery, providing excellent non-respiratory oxygenation. As a relatively new oxygen delivery method, it has gained widespread use.
- Conditions
- Liver Cirrhosis, Polyps of Colon, Gastrointestinal Dysfunction
- Trial name
- NCT07252102
- Testing
- High-flow nasal catheter oxygen, regular nasal catheter oxygen
- Where
- 3 sites in China
- Volunteers
- 450 people
- Sponsor
- Zhejiang University
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Non-invasive Ventilation Versus High Flow Oxygen
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute…
- Trial name
- HFO (NCT03758508)
- Testing
- High Flow Oxygen nasal cannula, Noninvasive ventilation
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Niguarda Hospital
Awake Tracheal Intubation, Difficult Airway
High-flow Nasal Cannula Versus Conventional Oxygen During Awake Tracheal Intubation With Difficult Airways
Study Background Airway management is one of the most fundamental and critical technical procedures in anesthesiology, critical care, and emergency medicine.
- Trial name
- NCT07384494
- Testing
- High-Flow Nasal Cannula, Ligh-Flow Nasal Cannula
- Where
- 6 sites in China
- Volunteers
- 336 people
- Sponsor
- Wenxian Li
Respiratory Failure, Respiratory Failure With Hypercapnia
Role of HFNC During FOB in Patients With Respiratory Failure
This prospective interventional study aims to evaluate the safety and efficacy of high-flow nasal cannula (HFNC) oxygen therapy during fiber-optic bronchoscopy in patients with respiratory failure.
- Trial name
- NCT07880964
- Testing
- High flow nasal canula
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University