Clinical trials: High Flow Oxygenation
Death, Brain
Efficacy of High-Flow Humidified Oxygen (HFHO) in Apneic Oxygenation for Apnea Testing: A Comparison With Continuous Positive Airway Pressure (CPAP)
Brain death (BD) is characterized by a severe brain injury resulting in irreversible loss of all brain and brainstem functions, while other organs may remain viable.
- Trial name
- APNEAFLO2W (NCT07640009)
- Testing
- Apnea test under HHFO followed by an apnea test under CPAP., Apnea test under CPAP followed by an apnea test under HHFO.
- Where
- 4 sites in France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Laryngoscopy, Apnea
High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia
Patients undergoing suspension laryngoscopy under general anaesthesia have oxygen delivered to their lungs through different methods. Inserting a tube in the trachea is the best means for oxygen delivery.
- Conditions
- Laryngoscopy, Apnea, Anesthesia
- Trial name
- OxALa (NCT03472118)
- Testing
- Nasal High Flow Oxygen
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- CMC Ambroise Paré
Hypoxemia, Gastrointestinal Endoscopy
THRIVE in Sedated Gastrointestinal Endoscopy
This prospective observational study aims to evaluate the effectiveness of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) compared to standard nasal cannula (SNC) oxygen supplementation in patients…
- Trial name
- NCT07487051
- Testing
- High-Flow Nasal Oxygen (THRIVE), Standard Nasal Cannula Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 222 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Lung Cancer, Lymphadenopathy
Assessment of High Flow Nasal Cannula Oxygenation in EBUS Bronchoscopy
This study is a prospective randomised trial where a computer will randomly allocate patients to one of two possible methods of delivering oxygen during the procedure of bronchoscopy.
- Trial name
- AHOE (NCT03226964)
- Testing
- high flow nasal oxygen
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
Postoperative Pulmonary Complications (PPCs)
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery.
- Trial name
- Hi-POP (NCT07464730)
- Testing
- High Flow Oxygen, Oxygen
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Deep Sedation, Dental Treatment
High-flow Nasal Oxygenation During Deep Sedation in Pediatric Dental Patients
It is important to choose an appropriate oxygenation technique during intravenous deep sedation in pediatric dental treatment. The study is to evaluate the efficacy and safety of high-flow nasal oxygenation in intravenous deep…
- Conditions
- Deep Sedation, Dental Treatment, Pediatric Patients
- Trial name
- NCT05762692
- Testing
- High-flow nasal oxygenation device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University
Airway Disorder
Optimizing High Flow Nasal Cannula Oxygenation in Pediatric Airway Procedures
The purpose of this study is to investigate which flow rate (higher versus lower) is most effective at increasing apneic time and preventing greater than 5% drop in desaturation, as well as assessing transcutaneous carbon dioxide…
- Trial name
- NCT06947902
- Testing
- High flow, Low Flow
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Mechanical Ventilation Complication, Weaning Failure
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Acute Respiratory Distress Syndrome, High-flow Oxygenation
- Trial name
- NCT06332768
- Testing
- Respiratory support
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Atelectasis
High Fresh Gas Flow After Intubation
Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation.
- Trial name
- NCT02216006
- Testing
- Control group, conventional ventilatory settings, High fresh gas flow, high minute ventilation
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Västmanland
Prevention of Intraoperative Hypoxia
High-flow Nasal Oxygenation Versus Standard Oxygenation for Gastrointestinal Endoscopy With Sedation in Obese Patients
Hypoxaemia is a major complication during gastrointestinal endoscopy (GIE) procedures (upper/lower) when performed under deep sedation in the procedure room especially with a body mass index above 30 kg/m².
- Trial name
- NCT06231836
- Testing
- High flow nasal cannula (HFNO), nasal cannula
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
High Flow Oxygen in Rapid Sequence Induction, Airway Morbidity
High Flow Oxygen With THRIVE Gives Better Oxygenation in Rapid Sequence Induction Patients
High flow oxygen results in better oxygenation in emergency cases needing rapid sequence induction for anaesthesia. Secondary outcome measure is time for any desaturation.
- Trial name
- THRIVE/RSI 1 (NCT02777840)
- Testing
- face mask oxygen, High flow oxygen
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Critical Illness
Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study
High-flow nasal oxygen therapy is commonly used in intensive care unit (ICU). Intra-hospital transfer of critical patients is frequent: 1) to perform diagnostic 2) between emergency room or medical wards and ICU.
- Trial name
- HospiFlow (NCT05311007)
- Testing
- Evaluation of the incidence and nature of adverse events
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Hypoxemia, Gastric Cancer (Diagnosis)
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease
Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve.
- Conditions
- Hypoxemia, Gastric Cancer (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD), Esophageal Cancer
- Trial name
- NCT07791979
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhejiang University
Hypoxemia During EBUS Bronchoscopy
High - Flow Nasal Cannula Versus Conventional Nasal Cannula During Endobronchial Ultrasound Procedure
EBUS bronchoscopy is performed in most centers under local anesthesia and moderate sedation. Both the bronchoscopy itself and the sedation can lead to decreased ventilation and a drop in oxygen saturation in the body.
- Trial name
- NCT06637280
- Testing
- High - flow nasal cannula, Standard nasal cannula
- Where
- 4 sites in Croatia, Greece and 2 more
- Volunteers
- 150 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Cerebral Oxygenation, Low Flow Anesthesia
The Effect Of Low-Flow And Hıgh-Flow Anesthesıa On Intracranıal Pressure
This prospective randomized study was conducted to evaluate the effects of low-flow and high-flow anesthesia on intracranial dynamics and cerebral oxygenation in patients undergoing laparoscopic hysterectomy in the Trendelenburg…
- Conditions
- Cerebral Oxygenation, Low Flow Anesthesia, Optic Nerve Sheath Diameter Measurement
- Trial name
- NCT07514026
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa City Hospital
Physical Therapy in Cardiac Surgery Patients
Impact of Physiotherapy Session in Cardiac Surgery Patients
This work consists, first of all, in making an inventory of the physiotherapy of the patient undergoing cardiac surgery under high flow oxygenation at the CHRU NANCY.
- Trial name
- NCT04793802
- Testing
- PHYSIO
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Central Hospital, Nancy, France
Procedural Sedation, Hypoxemia
HFNO Versus Face Mask for Cerebral Oxygenation During Procedural Sedation
This prospective randomized controlled trial aims to compare the effects of high-flow nasal oxygen (HFNO) and conventional face mask oxygen therapy on cerebral oxygenation during procedural sedation performed outside the…
- Conditions
- Procedural Sedation, Hypoxemia, Cerebral Oxygenation, SEDLine
- Trial name
- NCT07718295
- Testing
- High-Flow Nasal Oxygen (HFNO), Conventional Face Mask Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Firat University
Anaesthesia, General, Anesthesia, Intravenous
Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing…
- Conditions
- Anaesthesia, General, Anesthesia, Intravenous, Ventilation
- Trial name
- NCT02706431
- Testing
- Hyperventilation
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital