Clinical trials: High Flow Oxygenation
Oxygen Inhalation Therapy
Effect of a Modified Oxygen Mask Associated to Nasal Prongs During a High Flow Oxygenation Method
The aim of this study is to determine the effect (on PaO2) of a modified mask associated to nasal cannula used for high flow oxygenation.
- Trial name
- NCT03319602
- Testing
- Double trunk mask add above a nasal canulae
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Laboratory of Movement, Condorcet, Tournai, Belgium
Gastrointestinal Endoscopy, Sedation
High-Flow Nasal Oxygenation Versus Standard Oxygenation in Gastrointestinal Endoscopy With Sedation.
This study is a randomized controlled trial comparing high-flow nasal oxygen therapy (HFNO) versus standard oxygen therapy (nasal prongs, nasopharyngeal catheter or standard face mask) during gastrointestinal (GI) endoscopy with…
- Trial name
- ODEPHI (NCT03829293)
- Testing
- High-flow nasal cannula oxygenation group
- Where
- 3 sites in France
- Volunteers
- 380 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Apneic Oxygenation, High-flow Nasal Cannulae
High-flow Nasal Oxygenation in Obese Patients During Apnea
Before going off to sleep patients are given oxygen to saturate blood with oxygen to extend time before a decrease in the level of oxygen in the blood occurs.
- Conditions
- Apneic Oxygenation, High-flow Nasal Cannulae, Bariatric Surgery, Anesthesia Induction
- Trial name
- NCT03195504
- Testing
- HFNC, CON (control)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Laryngeal Disease
Randomized Controlled Trial:High-flow Oxygen Therapy and Tracheal Intubation for Laryngeal Microsurgery
Over time, the accumulation of carbon dioxide reduces the pressure gradient for the alveolar transfer of oxygen, limiting the successful duration of apneic oxygenation.
- Trial name
- NIRS_ORL (NCT05400642)
- Testing
- THRIVE, mechanical ventilation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
Oxygen Titration in Preterm Infants to Manage Lung Disease
IntellO2 vs Manual Control for Optimizing Oxygenation in Infants
The overall objective of this study is to demonstrate that the IntellO2 device providing automated control of fraction of inspired oxygen (FiO2) adjustments in spontaneously breathing infants with fluctuating arterial blood…
- Trial name
- NCT02074774
- Testing
- IntellO2, Manual control
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- Vapotherm, Inc.
Hypoxemia, Esophageal Cancer
Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients
Hypoxaemia during sedated gastrointestinal endoscopy exceeds 40 % in morbidly obese (BMI ≥ 35 kg m-²) patients. High-flow nasal cannula alone often fails because of persistent airway collapse.
- Conditions
- Hypoxemia, Esophageal Cancer, Morbidly Obese Patients, Gastric Cancer
- Trial name
- NCT07175155
- Testing
- COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation, High-Flow Nasal Cannula Oxygenation
- Where
- 5 sites in China
- Volunteers
- 410 people
- Sponsor
- Zhejiang University
Foreign Bodies, Tumor
The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients
The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on maintenance of oxygenation and removal of carbon dioxide during apnoeic period in pediatric patients undergoing general…
- Conditions
- Foreign Bodies, Tumor, Stenosis of Trachea, Bronchus
- Trial name
- NCT03905733
- Testing
- Optiflow
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Apnea, Anesthesia
Functional Residual Capacity Under Apnoeic Oxygenation with Different Flow Rates in Children
During induction of general anaesthesia physiological breathing stops and needs to be artificially established with facemask ventilation, and finally tracheal intubation or placement of a supraglottic airway.
- Conditions
- Apnea, Anesthesia, Intubation Complication, Children, Only
- Trial name
- FUTURE (NCT05672329)
- Testing
- 0.2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 4 L/kg/min, FiO2 1.0 + continuous jaw thrust
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- Thomas Riva
Apneic Oxygenation
The Efficacy of Transnasal Humidified Rapid-insufflation Ventilatory Exchange During Laryngeal Microsurgery
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) was revealed to prolong apneic time with a slow increase in carbon dioxide; thus, has been used for preoxygenation in patients with difficult airways or…
- Trial name
- NCT03629353
- Testing
- endotracheal intubation, high flow nasal cannula
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
Induction of General Anesthesia
Effect of High-flow Nasal Oxygenation on Gastric Insufflation in Children
This is a randomized controlled study to compare the incidence of gastric insufflation when using high-flow nasal oxygenation and facemask ventilation in pediatric patients.
- Trial name
- NCT06204653
- Testing
- HFNO group, MV group
- Volunteers
- 70 people
- Sponsor
- Ajou University School of Medicine
Thoracic Surgery
High-Flow Nasal Catheter (HFNC) Compared With Conventional Oxygenation
The purpose of this study, is to clarify whether there is benefit from the perioperative use of HFNC in thoracic surgeries, from intubation to the postoperative period, evaluating hipoxemia during orotracheal intubation…
- Trial name
- NCT05910788
- Testing
- high flow nasal cannula
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Covid19
Effect of Prone Positioning Combined With High Flow Oxygen Therapy on Oxygenation During Acute Respiratory Failure Due to COVID-19
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients with AHRF, the need for invasive mechanical ventilation is associated with high mortality.
- Trial name
- DeCOPO (NCT04543760)
- Testing
- Prone position, Supine position
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Respiratory Failure
Flow veRsus OxygeNaTion In acutE ReSpiratory Failure
High flow nasal oxygen therapy has been widely used but guidelines as to the optimal starting flow rate and oxygen percentage are not available.
- Trial name
- Frontiers (NCT03223948)
- Testing
- 'Optiflow'
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hypoxia, Gastric Cancer
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Gastroscopy Sedated by Propofol
Hypoxia is the most common adverse events during sedated gastroscopy. In present study, high-flow nasal cannula oxygenation will be utilized in order to reduce the hypoxia.
- Conditions
- Hypoxia, Gastric Cancer, Esophagus Cancer, Adverse Event
- Trial name
- HONCHO (NCT03332433)
- Testing
- High-flow nasal cannula oxygenation
- Where
- 3 sites in China
- Volunteers
- 2,034 people
- Sponsor
- RenJi Hospital
Hypoxemia During Surgery
High-Flow Nasal Oxygen vs. Face Mask During Sedoanalgesia in Non-Intubated Thoracoscopic Pericardial Window Surgery
This is a prospective, randomized, parallel-group clinical trial designed to evaluate the effects of high-flow nasal oxygen therapy (HFNOT) versus conventional oxygen mask (COM) on perioperative hypoxia in patients undergoing…
- Trial name
- HIFI-NIVATS (NCT07432607)
- Testing
- High-Flow Nasal Oxygen Therapy (HFNOT), Conventional Oxygen Mask (COM)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ebru Girgin Dinc
Apnea, Respiration; Arrest
The Effect of High-flow Nasal Oxygen Flow Rate on Gas Exchange During Apnoea
Apnoeic oxygenation refers to oxygenation that occurs through the insufflation of oxygen into the lungs in the absence spontaneous respiration or positive pressure ventilation.
- Conditions
- Apnea, Respiration; Arrest, Anesthesia
- Trial name
- Apox-HFNO (NCT05124093)
- Testing
- Apnoeic oxygenation
- Where
- Ireland
- Volunteers
- 114 people
- Sponsor
- University College Hospital Galway
Hypoxemic Respiratory Failure
Asymmetrical HFNCO vs Standard HFNCO Post Cardiac Surgery Patients
High-flow oxygen therapy has been applied after extubation in cardiac surgery patients with a well-known successful efficacy. The current authors plan to conduct a prospective, randomized, controlled study of the Asymmetrical…
- Trial name
- NCT06521489
- Testing
- Asymmetrical High Flow Nasal Cannula Oxygenation, Conventional High Flow Nasal Cannula Oxygenation
- Where
- Greece
- Volunteers
- 63 people
- Sponsor
- National and Kapodistrian University of Athens
Anesthesia, General, Apnea
High-flow Nasal Oxygenation for Open Mouth
This study aims to evaluate the effect of high-flow nasal oxygenation on safe apnea time for children undergoing general anesthesia, with their mouth open.
- Trial name
- NCT04290728
- Testing
- Apnea with high-flow nasal cannula, Apnea
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
COPD Exacerbation
Effect of High Flow Nasal During Exercise in COPD Patients
Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training.
- Trial name
- AiRehab (NCT03058081)
- Testing
- High Flow nasal cannula
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier du Havre