Clinical trials: High Flow Oxygenation
Airway Management
Apneic Intubation Critically Ill Children
This study compares the actual standard of care of intubation in Swiss pediatric intensive care units vs the use of apneic oxygenation using either high flow or low flow oxygen to prevent hypoxemia and to prolong apnea time…
- Trial name
- Penguin (NCT04890288)
- Testing
- Interventional randomized controled trial (RCT) comparing two oxygenation methods to reduce desaturation during intubation vs standard of care.
- Where
- 7 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Respiratory Failure, Cancer
Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order
ICU care of patients considered "palliative" but without contraindications to admission to intensive care, for whom a do-not intubate order decision was made upon admission represents a particular target for non-invasive…
- Conditions
- Acute Respiratory Failure, Cancer, Hematologic Malignancy, Cardiac Insufficiency
- Trial name
- OXYPAL (NCT03673631)
- Testing
- NIV, NFHC-O2
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Poitiers University Hospital
Acute Hypoxemic Respiratory Failure
A Novel Index to Predict the Failure of High-flow Nasal Cannula in Patients with Acute Hypoxemic Respiratory Failure
High-flow nasal cannula (HFNC) is increasingly used in patients with acute hypoxemic respiratory failure (AHRF) and has been shown to improve outcome in specific patient categories, including community acquired pneumonia and…
- Trial name
- NCT05549882
- Testing
- no intervention
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Southeast University, China
Hypoxia, Esophageal Cancer
Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastrointestinal Endoscopy for Obese Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy, particularly in obese patients.
- Conditions
- Hypoxia, Esophageal Cancer, Gastric Cancer, Polyp of Colon
- Trial name
- NCT06812403
- Testing
- the COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Oxygen, pH
Comparison of the Effects of High-flow Nasal Cannula Oxygen and Jet Ventilation Techniques
Endoscopic microsurgical procedures of the larynx (direct examination-bx, microlaryngeal resection) require the anesthesiologist and surgeon to work in the same area throughout the procedure, and while ventilation is provided…
- Conditions
- Oxygen, pH, End-tidal Carbon Dioxide
- Trial name
- NCT05746949
- Testing
- oxygenization techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Respiratory Failure
The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure
High flow nasal cannula (HFNC) oxygen therapy is increasingly used for hypoxemic respiratory failure and is proving useful in avoiding or delaying intubation and mechanical ventilation.
- Trial name
- NCT05708287
- Testing
- HFNC
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Hadassah Medical Organization
Lung Neoplasms, Pneumothorax
HFNO Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation
With the continuous strengthening of the concept of rapid rehabilitation, great progress has been made in minimally invasive thoracic surgery, and thoracoscopic surgery has developed rapidly.
- Trial name
- NCT05666908
- Testing
- HFNO
- Volunteers
- 112 people
- Sponsor
- Shenzhen Second People's Hospital
Robotic Surgery
Perioperative High-flow Nasal Oxygen in Patients Undergoing Robotic Surgery
The aim of the study is to assess whether perioperative use of high-flow nasal oxygen (HFNO) during the period from induction of anesthesia until discharge from the post-anesthesia care unit in patients undergoing…
- Trial name
- Periop HFNO (NCT07591610)
- Testing
- High flow nasal oxygen
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Beth Israel Deaconess Medical Center
Unrecognized Condition
Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
If a patient speaks during the process of preoxygenation with high-flow nasal oxygen via the Optiflow™ system, is the efficacy reduced as measured by end-tidal lung oxygen content?
- Trial name
- NCT03766646
- Testing
- Optiflow
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Noninvasive Ventilation, Respiratory Insufficiency
The Effect of High-flow Nasal Oxygenation to the Saturation During Analgo-sedation in Different ASA Risk Class Patients
Analgo-sedation is standard procedure in anesthesiology practice and is often given for colonoscopy in the setting of daily hospital.
- Conditions
- Noninvasive Ventilation, Respiratory Insufficiency, Deep Sedation, Hypoxia
- Trial name
- NCT03687385
- Testing
- high-flow nasal oxygenation (HFNO), low-flow nasal oxygenation (LFNO)
- Volunteers
- 126 people
- Sponsor
- Anita Vukovic
Respiratory Syncytial Virus Bronchiolitis
Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.
Bronchiolitis in infants and young children often requires respiraty support. In Denmark Continous Positive Airway Pressure ( CPAP) are routinely used in children with moderate-severe bronchiolitis.
- Trial name
- NCT02618213
- Testing
- Optiflow Junior, Continous Positive Airway Pressure
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Upper Airway Obstruction, Apnea, Obstructive
Improve Oxygenation and Capnographic Detection During Sedative EGD
The purpose of this study is to compare the effect of mandibular advancement bite block and high flow nasal cannula to standard bite block for oxygenation, capnographic measurement, prevention of hypoxemia, intervention events…
- Trial name
- NCT03138850
- Testing
- Olympus standard bite block, YX mandibular advancement bite block, Optiflow High flow nasal cannula
- Where
- Taiwan
- Volunteers
- 170 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Sedation Complication, Obesity
Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy
Patients suffering from pathology of posterior eye chamber such as diabetic retinopathy, retinal detachment, traumatic eye injury, retained lens fragments, macular hole, pucker, dislocated intraocular lens after cataract surgery…
- Conditions
- Sedation Complication, Obesity, Hypoxic Respiratory Failure, Airway Obstruction, Nasal
- Trial name
- NCT04049240
- Testing
- Device: low-flow nasal oxygenation (LFNO) 18<BMI<30 kg/m2, Device: low-flow nasal oxygenation (LFNO) 30≤BMI<35 kg/m2, Device: low-flow nasal oxygenation (LFNO) BMI≥35 kg/m2
- Where
- Croatia
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Oxygen Deficiency
High-flow Nasal Cannula for Pediatric Anesthetic Induction
Endotracheal intubation in infants often involves more than one attempt, and oxygen desaturation is common. It is unclear whether nasal high-flow therapy, which extends the time to desaturation during elective intubation in…
- Trial name
- NCT05578131
- Testing
- high flow nasal oxygen, face mask
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Acute Respiratory Failure, Intratracheal Intubation
Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure
The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)
- Trial name
- FLORALI2 (NCT02668458)
- Testing
- High Flow nasal canula oxygen therapy, Noninvasive ventilation
- Where
- 27 sites in France
- Volunteers
- 320 people
- Sponsor
- Poitiers University Hospital
Surgery
OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone
This is an observational, prospective study of patients undergoing a surgical procedure. Three parallel studies are taking place with collaborators in other countries.
- Trial name
- NCT05495841
- Testing
- Pre-oxygenation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
COVID-19 Pneumonia, COVID-19 Acute Respiratory Distress Syndrome
High-flow Nasal Oxygenation and Non-invasive Ventilation Strategies for the Treatment of Covid-19 Pneumonia
HFNO and NIV strategies are the most commonly used strategies for the treatment of hypoxia in patients with a diagnosis of COVID-19 who are still followed in the intensive care unit, but there is no study comparing the two yet.
- Trial name
- NCT05137431
- Testing
- HFNO and NIV
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Medipol University
Gastric Cancer, Intestinal Cancer
HFNO Reduces Hypoxia During Sedated Gastroscopy or Colonoscopy in High Risk Patients
The objective of this study is to observe the preventive effects of high flow nasal oxygenation on the incidence of hypoxia during gastroscopy or colonoscopy sedated with propofol in high-risk patients.
- Conditions
- Gastric Cancer, Intestinal Cancer, Intestine Adenoma, Gastritis
- Trial name
- HRISK (NCT05510388)
- Testing
- High-flow nasal cannula oxygenation, Regular nasal cannula oxygenation
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- RenJi Hospital
Hypercapnic Respiratory Failure, Acute Copd Exacerbation
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
Current evidence suggests a mechanistic and physiological rationale for the use of high flow nasal cannula (HFNC) in acute respiratory hypoxemic failure (AHRF) based on physiological studies in airway models, healthy volunteers…
- Trial name
- NCT05497986
- Testing
- High flow nasal cannula, Conventional low flow oxygenation
- Where
- 3 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Hôpital de Verdun
Respiratory Disease, Respiratory Distress Syndrome
Oxygenation Efficacy of "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Based on early bench-testing data and subsequent clinical case studies in the U.S., "Intrinseque Health" non-rebreathing mask (IHNRM) has delivered virtual elimination of air entrainment and preferential delivery of all available…
- Conditions
- Respiratory Disease, Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- NCT06310629
- Testing
- High Flow Nasal Cannula, "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital