Clinical trials: High Risk Bleeding
Peptic Ulcer Hemorrhage
Effect of High-dose Oral Rabeprazole on Recurrent Bleeding After the Endoscopic Treatment of Bleeding Peptic Ulcers
This study is conducted to compare and evaluate the effect of administering a high-dose intravenous proton pump inhibitors or high-dose oral Rabeprazole in preventing recurrent bleeding after the endoscopic treatment of bleeding…
- Trial name
- NCT00838682
- Testing
- omeprazole sodium IV, Rabeprazole
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- The Catholic University of Korea
Postpartum Hemorrhage
Carbetocin Versus Misoprostol in High Risk Patients for Postpartum Hemorrhage After C.S.
We will compare between Carbitocin and Misoprostol in prevention of postpartum hemorrhage in high risk patients after C.S.
- Trial name
- PPH (NCT02277067)
- Testing
- Carbetocin, Misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Compensated Advanced Chronic Liver Disease, Variceal Hemorrhage
Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004)
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices, esophagogastroduodenoscopy (EGD) should be performed.
- Trial name
- NCT04546360
- Testing
- Esophagogasrtoduodendoscopy, spleen stiffness measurement and liver stiffness measurement.
- Where
- 6 sites in China
- Volunteers
- 381 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Nonneoplastic Condition
Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura
RATIONALE: Drugs, such as prednisone and dexamethasone, may change the immune system and be an effective treatment for primary immune thrombocytopenic purpura.
- Trial name
- ITP0207 (NCT00657410)
- Testing
- dexamethasone, prednisone, quality-of-life assessment
- Where
- 42 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Postpartum Hemorrhage (Primary), Hemorrhage
U-CaVIT Versus Standard of Care for Prevention of Atonic Postpartum Hemorrhage After Cesarean Section in High-risk Women.
This pilot study aims to assess performance, safety and feasibility of U-CaVIT method (Uro-Catheter Vacuum Induced Tamponade), using the Rüsch® Brillant Silicone Balloon Catheter, an urological catheter, for the prevention of…
- Conditions
- Postpartum Hemorrhage (Primary), Hemorrhage, Postpartum Complication, Delivery ,Complications,Maternal
- Trial name
- UCaVIT Pilot (NCT07019623)
- Testing
- Rüsch® Balloon Catheter Ch. 24, Ultrasonography
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Christian Haslinger
Primary Immune Thrombocytopenia (ITP)
High-Dose Dexamethasone Combined With Orelabrutinib Versus High-Dose Dexamethasone Combined With Placebo in Adult Patients With Newly Diagnosed Primary Immune Thrombocytopenia
This is a randomized controlled study of high-dose Dexamethasone combined with Orelabrutinib versus high-dose Dexamethasone combined with placebo in adult patients with newly diagnosed Primary Immune Thrombocytopenia.
- Trial name
- NCT07559331
- Testing
- High-Dose Dexamethasone Combined with Orelabrutinib
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shandong University
Intracranial Aneurysms, Subarachnoid Hemorrhage, Aneurysmal
Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms
The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms.
- Trial name
- SIREN (NCT07387575)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Novi Sad
Blood Loss, Surgical
Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty
The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT
- Trial name
- NCT03044041
- Testing
- Tranexamic Acid
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Brain Ischemia, Intracranial Hemorrhages
PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study
Through this study, the investigators are to prove that Cilostazol effectively prevent progression of intima-medial thickness in ischemic stroke patients with high risk of cerebral hemorrhage, along with no significant increase…
- Trial name
- PICASSO-IMT (NCT02483169)
- Testing
- cilostazol, Probucol, Aspirin
- Volunteers
- 800 people
- Sponsor
- Asan Medical Center
Immune Thrombocytopenia
Different Cycles of High-dose Dexamethasone for Initial Management of Primary Immune Thrombocytopenia (ITP)
The project was organized by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of different cycles of high-dose dexamethasone for the treatment of adults with newly-diagnosed primary immune…
- Trial name
- NCT02642380
- Testing
- Dexamethasone (4 cycles), Dexamethasone (1 cycle)
- Where
- China
- Sponsor
- Shandong University
Prolonged DAPT in ACS Patients With Hisk of Both Ischemic and Hemorrhage
Optimal antiPlatelet Therapy for High Bleeding and Ischemic RISK Patients Trial
Current guidelines recommend that patients with ACS undergoing stent implantation might be offered extended DAPT treatment for up to 30 months if necessary.
- Trial name
- OPT-BIRISK (NCT03431142)
- Testing
- Clopidogrel, Clopidogrel+aspirin
- Where
- 103 sites in China
- Volunteers
- 7,758 people
- Sponsor
- Shenyang Northern Hospital
Major hæmorrhage
Early Versus Late Resumption of Anticoagulation in Patients With Both High Thrombosis Risk and Major HEmoRrhage
In patients with a high thromboembolic risk, withdrawing anticoagulant treatment is recommended in some situations, including when major hæmorrhage occurs. But withdrawing treatment can be risky.
- Trial name
- RATHER (NCT02091479)
- Testing
- UFH Early group, UFH Late group
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Immune Thrombocytopenic Purpura
Eltrombopag and High-dose Dexamethasone as First Line Treatment for IT
The purpose of this study is to determine the response rate and response duration with the combination of eltrombopag and high-dose dexamethasone
- Trial name
- NCT01652599
- Testing
- Eltrombopag and dexamethasone
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Purpura, Idiopathic Thrombocytopenic Purpura
rhTPO Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of ITP
The project was undertaking by Qilu Hospital of Shandong University and other 13 well-known hospitals in China. In order to report the efficacy and safety of Recombinant Human thrombopoietin combining with Dexamethasone for the…
- Trial name
- NCT01734044
- Testing
- recombinant human thrombopoietin (rhTPO); dexamethasone, Dexamethasone
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Shandong University
Antiphospholipid Syndrome (APS), Cohort Study
DOAC Versus VKA in Patients With Non-high-risk APS : Prospective Cohort Study
Antiphospholipid syndrome (APS) is a thrombotic disease requiring prolonged anticoagulation. Direct oral anticoagulants (DOACs) are indicated as 1st-line therapy in venous thrombosis, compared with VKAs, due to their easier…
- Conditions
- Antiphospholipid Syndrome (APS), Cohort Study, Thrombotic and Bleeding Events
- Trial name
- DOWAPS (NCT06884384)
- Testing
- Additional blood collection during routine blood sampling at the inclusion (33.9 ml) and at the thrombotic recurrence (between 3.5 and 5 ml), Completion of a questionnaire on compliance with anticoagulant treatment, Completion of a questionnaire on satisfaction with treatment anticoagulant
- Where
- 13 sites in France
- Volunteers
- 310 people
- Sponsor
- Central Hospital, Nancy, France
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital