Clinical trials: High Risk Medications
Transfusion-associated Circulatory Overload
Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
This is a pilot double-blinded placebo-controlled randomized controlled trial (RCT) to evaluate the feasibility of conducting a multicenter, randomized, placebo-controlled trial to assess the efficacy of pre-transfusion…
- Trial name
- NCT02802696
- Testing
- Furosemide, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Oral Neoplasm
Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment
The purpose of this observational study is to evaluate the utility of the S100A7 immunohistochemistry signature-based assessment - STRATICYTE - in determining the risk of progression to cancer of clinically suspicious oral…
- Trial name
- NCT04622462
- Testing
- Standard of Care Histopathology, STRATICYTE Assessment
- Where
- 3 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Proteocyte Diagnostics Inc.
Hypercholesterolemia
Study of an Approved Drug With a Statin (a Medication That Lowers Cholesterol Levels) as Compared to Statin Therapy Alone in Patients With High Cholesterol (0653-040)
The purpose of this 6-week study is to compare the reduction in specific levels of cholesterol in patients with high cholesterol.
- Trial name
- NCT00092586
- Testing
- MK0653, ezetimibe, Comparator: statins
- Volunteers
- 2,904 people
- Sponsor
- Organon and Co
Acute Coronary Syndrome, Angina Pectoris
Complex All-comers and Patients With Diabetes or Prediabetes, Treated With Xience Sierra Everolimus-eluting Stents
Drug eluting stents (DES) are widely used for treatment of coronary artery lesions. The Xience Sierra stent has a refined design of the metal stent backbone and is used in patients with various clinical syndromes and in different…
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- NCT04475380
- Testing
- Percutaneous coronary intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 1,757 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Coronary Artery Lesions
XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR Patients.
XIENCE 90 study is a prospective, single arm, multi-center, open label trial to evaluate the safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR) undergoing percutaneous coronary…
- Trial name
- NCT03218787
- Testing
- XIENCE, DAPT
- Where
- 101 sites in United States
- Volunteers
- 2,047 people
- Sponsor
- Abbott Medical Devices
Hypertension
Community Hypertension Assessment Trial (CHAT)
The Community Hypertension Assessment Trial (CHAT) is an investigation of the effect of community pharmacy based blood pressure (BP) monitoring sessions led by peer health educators, with feedback to family physicians, on the…
- Trial name
- NCT00217334
- Testing
- Volunteer-led pharmacy sessions with feedback to physicians
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
HDL, Drug Safety
Safety, Immunogenicity and Dose Response of ATH03, a New Vaccine Against the Cholesterol Ester Transfer Protein (CETP)
Phase 1 Study :Safety, Immunogenicity and Dose response of ATH03, a new vaccine against the cholesterol ester transfer protein (CETP), in healthy male subjects with high density lipoprotein cholesterol (HDLc) blood concentrations…
- Trial name
- NCT01284582
- Testing
- ATH03
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Affiris AG
PICU, Nurses
Smart Mind Maps in Promoting Safe Administration of High-Alert Medications
In PICU setting, drug administration, monitoring, and prescribing errors made up most cases (54%) of MEs . Emphasizes these issues requires a multifaceted approach, including staff training, creation of innovative cognitive…
- Trial name
- HAMs- PICU (NCT07320196)
- Testing
- smart mind mapsde
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Crohn Disease
Triple Combination Therapy in High Risk Crohn's Disease (CD)
The purpose of this study is to determine the effect of triple combination therapy with an anti-integrin (vedolizumab intravenous [IV]), a tumor necrosis factor (TNF) antagonist (adalimumab subcutaneously [SC]), and an…
- Trial name
- NCT02764762
- Testing
- Vedolizumab, Adalimumab, Methotrexate
- Where
- 32 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- Takeda
Hypertension
Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension
This trial is aimed to assess the efficacy and safety of a fixed-dose combination therapy with Valsartan and Chlorthalidone, Vs Valsartan or Chlorthalidone alone for treatment of adult patients with diagnosis of arterial…
- Trial name
- NCT01850160
- Testing
- GROUP A: Valsartan plus Chlorthalidone, GROUP B: Valsartan, GROUP C: Chlorthalidone
- Where
- 8 sites in Colombia, Ecuador
- Volunteers
- 124 people
- Sponsor
- Farma de Colombia SA
End-stage Renal Disease, Prevention of Thromboembolic Events
Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis
In this study researchers want to learn about the safety of drug Osocimab at lower-dose and higher-doses in adult participants with kidney disease undergoing regular dialysis (a procedure that uses a machine to get rid of toxins…
- Conditions
- End-stage Renal Disease, Prevention of Thromboembolic Events, Hemodialysis, Hemodiafiltration
- Trial name
- CONVERT (NCT04523220)
- Testing
- BAY1213790 (Osocimab)
- Where
- 151 sites in United States, Australia and 17 more
- Volunteers
- 704 people
- Sponsor
- Bayer
Critical Pathways
Development of a Hospital Service That Uses Critical Pathway (Protocolized) Care Plans to Provide High-Quality, High-Reliability, Evidence-Based Medical Care
Our broad, long-term objective is to create a new non-resident (non-teaching) hospital service that uses patient-centered critical pathway care plans for treating patients in St. Marys Hospital.
- Trial name
- NCT00275587
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Mayo Clinic
Drug-eluting Stent, Coronary Artery Disease
Genoss DES in Patients With a High Risk of Ischemic Events (GENTLE Registry)
This is a prospective cohort study to evaluate the long-term effect and safety of Genoss drug-eluting stents (DES) in patients with coronary artery disease with high ischemic features.
- Trial name
- NCT05448625
- Testing
- Genoss DES
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Gut Dysbiosis for TMAO Production From Red Meat Consumption
Development of Microbial Metabolism Gene Tests for Facilitating Precision Health and Preventive Medicine-Evaluation of TMAO Production in Human Body From High-carnitine Diet by Fecal Gbu Gene Testing
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to Trimethylamine n-oxide (TMAO) in the body by certain…
- Trial name
- NCT07322575
- Testing
- Beef
- Where
- Taiwan
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypertension, Primary Hypertension
Text Message Support to Help Adults With Newly Diagnosed High Blood Pressure Control Their Blood Pressure in Primary Care Clinics in Germany and Pakistan
The goal of this clinical trial is to learn if text messages can help adults with newly diagnosed high blood pressure (hypertension) bring their blood pressure under control.
- Trial name
- NCT07878728
- Testing
- mHealth Text Message Program, Usual Care
- Where
- Pakistan
- Volunteers
- 1,295 people
- Sponsor
- GIFT University
Coronary Artery Disease
PREVAIL Paclitaxel-coated Balloon in Small Coronary Disease and High-bleeding Risk Patients
Post-market, prospective, observational, multicenter, non-intervention study, to demonstrate the effectiveness of drug-coated ballon (DCB)therapy in real-world patients with small native vessel coronary artery disease, and to…
- Trial name
- PARIS (NCT06321757)
- Testing
- Percutaneous Coronary Intervention with DCB and DAPT
- Where
- 19 sites in Italy, Portugal and 1 more
- Volunteers
- 501 people
- Sponsor
- Fundación EPIC
Hypercholesterolemia, Atherosclerosis
Assessment of Potential Interaction Between Ezetimibe and Rosuvastatin in Healthy Subjects With High Cholesterol (P03317)
The purpose of this study is to obtain data of the coadministration of ezetimibe and rosuvastatin to support the concomitant use of these two drugs in patients requiring additional cholesterol-lowering management.
- Trial name
- NCT00651144
- Testing
- Ezetimibe + Rosuvastatin, Rosuvastatin, Ezetimibe
- Volunteers
- 40 people
- Sponsor
- Organon and Co
Fallopian Tube Carcinoma, Fallopian Tube Endometrioid Adenocarcinoma
Testing the Combination of the Study Drugs Cediranib and Olaparib in Recurrent Ovarian Cancer
This phase II trial studies how well olaparib and cediranib maleate work in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back after a period of improvement (recurrent).
- Conditions
- Fallopian Tube Carcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Ovarian Carcinoma
- Trial name
- NCT02345265
- Testing
- Biopsy Procedure, Biospecimen Collection, Cediranib Maleate
- Where
- 20 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Substance Abuse
Hair Testing to Assess Consumption of Illicit Psychotropic Agents and Alcohol by Patients Treated With High-dose Buprenorphine and Methadone. Search for a Pharmacogenetic Contribution to Low Efficacy of Substitution Medications
Justification and aims of the study: The principal aim of use of opiate substitutes such as methadone or high-dose buprenorphine (HDB) is to reduce the need or the desire to consume the opiate to which the patient is addicted.
- Trial name
- NCT01285856
- Testing
- hair and saliva samples
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8
Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer
This phase III trial studies how well atezolizumab added to the usual radiation therapy works in treating patients with stage I-IIA non-small cell lung cancer.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8
- Trial name
- NCT04214262
- Testing
- Atezolizumab, Biospecimen Collection, Computed Tomography
- Where
- 390 sites in United States
- Volunteers
- 417 people
- Sponsor
- National Cancer Institute (NCI)