Clinical trials: High Risk of Stroke
Post-Stroke Cognitive Impairment (PSCI), Repetitive Transcranial Magnetic Stimulation (rTMS)
High-Frequency Repetitive Transcranial Magnetic Stimulation for Cognitive Improvement in Patients With Post-Stroke Cognitive Impairment
To clarify the clinical efficacy of high-frequency rTMS on patients with post-stroke cognitive impairment, fNIRS and EEG techniques were used to observe the changes in brain functional activities of patients with post-stroke…
- Conditions
- Post-Stroke Cognitive Impairment (PSCI), Repetitive Transcranial Magnetic Stimulation (rTMS), Stroke
- Trial name
- NCT07546877
- Testing
- repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Stroke
The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke
Emerging studies have shown that statin treatment has pleiotropic non-cholesterol-dependent effects in the setting of ischemic stroke.
- Trial name
- SEATIS (NCT02452502)
- Testing
- atorvastatin
- Where
- 2 sites in China
- Volunteers
- 254 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Stroke Rehabilitation
Biomarkers of Reaction To HIIT Exercise
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy.
- Conditions
- Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic, Walking, Difficulty
- Trial name
- BReaTHE (NCT06059872)
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Stroke
Stroke Therapy With Brain Oscillation Synchronized Stimulation
This randomized, controlled, double-blind clinical pilot trial investigates the therapeutic potential of a novel personalized therapeutic brain-stimulation protocol in chronic stroke patients with spasticity.
- Trial name
- STROKEBOSS (NCT05005780)
- Testing
- Negative peak triggered 100 Hz triplet burst TMS, 1 Hz rTMS
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Stroke
The Safety of High Dose Minocycline in the Patient Population Undergoing Carotid Revascularization
The purpose of this study is to evaluate the safety and tolerability of high-dose minocycline in the patient population undergoing carotid revascularization procedures, namely carotid endarterectomy (CEA) and carotid artery…
- Trial name
- NCT02178813
- Testing
- Administration of minocycline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Stroke, Dysphagia
PES to Avoid Extubation Failure in Intubated Stroke Patients at High Risk of Severe Dysphagia
Post-extubation dysphagia (PED) recently became a growing concern as a major risk factor for extubation failure and significant contributor to poor patient outcomes with prevalence rates ranging from 12% to 69%, being highest in…
- Conditions
- Stroke, Dysphagia, Extubation Failure
- Trial name
- NCT04010617
- Testing
- Pharyngeal Electrical Stimulation (PES)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Cerebrovascular Stroke
Carotid Doppler Findings of High Risk Group of Stroke
To evaluate the effect of different risk factors on carotid arteries via ultrasonography parameters.
- Trial name
- NCT05920291
- Volunteers
- 85 people
- Sponsor
- Assiut University
Plaque, Atherosclerotic Disease
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
The BioImage Study is a study of the characteristics of subclinical cardiovascular disease, as measured by imaging modalities, unsupervised circulating biomarker measurements, and risk factors that predict progression to overt…
- Conditions
- Plaque, Atherosclerotic Disease, Heart Disease, Stroke
- Trial name
- NCT00738725
- Where
- 2 sites in United States
- Volunteers
- 7,687 people, healthy volunteers welcome
- Sponsor
- BG Medicine, Inc
Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation
Blood Clotting Markers and Heart Ultrasound in People With Device-Detected Atrial Fibrillation
The purpose of this observational study is to investigate whether blood tests related to blood clotting are associated with established clinical stroke risk scores, the total amount of device-detected atrial fibrillation recorded…
- Conditions
- Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation, Atrial High Rate Episodes
- Trial name
- DDAF-HEV (NCT07713615)
- Where
- Denmark
- Volunteers
- 222 people
- Sponsor
- Andreas Sjøholm-Christensen
Asymptomatic, Artery
Stenting Versus Best Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis
Background. Carotid artery stenting (CAS) recently has become an accepted method for treatment of patients with high-grade carotid artery stenosis, who are at an increased risk for surgical carotid endarterectomy (CEA).
- Trial name
- NCT00497094
- Testing
- carotid artery stenting
- Where
- Austria
- Volunteers
- 148 people
- Sponsor
- Vienna General Hospital
Intracranial Atherosclerosis, Acute Ischemic Stroke
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with alirocumab results in greater change from baseline in intracranial atherosclerotic plaque at week 26 than control in adults with acute ischemic stroke…
- Conditions
- Intracranial Atherosclerosis, Acute Ischemic Stroke, ICAS - Intracranial Atherosclerosis
- Trial name
- TOPICAL-MRI (NCT05001984)
- Testing
- Alirocumab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Fluid Overload, Fluid Loss
Atrial Natriuretic Peptide in Assessing Fluid Status
Biomarkers can play a significant role in fluid status assessment intraoperatively.
- Conditions
- Fluid Overload, Fluid Loss, Volume Overload, Cardiac Disease
- Trial name
- NCT05070819
- Testing
- pro-ANP
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Stroke, Ischemic, Sarcopenia
HIIT vs MCIT for Stroke-Related Sarcopenia in Ischemic Stroke
The aim of this study is to investigate the effect of post-stroke sarcopenia on prognosis and clinical outcomes in patients with ischemic stroke and to compare the effects of High Intensity Interval Training (HIIT) and Moderate…
- Trial name
- NCT07456956
- Testing
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training (MCIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Fenerbahce University
Ischemic Cerebral Infarction
Ongericimab Injection Reducing Recurrence of Ischemic Stroke
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by…
- Trial name
- ORIS (NCT07242599)
- Testing
- High target group, Low target group
- Where
- 199 sites in China
- Volunteers
- 4,810 people
- Sponsor
- Beijing Tiantan Hospital
Brain Ischemia, Intracranial Hemorrhages
PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study
Through this study, the investigators are to prove that Cilostazol effectively prevent progression of intima-medial thickness in ischemic stroke patients with high risk of cerebral hemorrhage, along with no significant increase…
- Trial name
- PICASSO-IMT (NCT02483169)
- Testing
- cilostazol, Probucol, Aspirin
- Volunteers
- 800 people
- Sponsor
- Asan Medical Center
Coronary Heart Disease, Stroke
Heart Disease on the Mend
The primary objective of this study was to evaluate the effectiveness of a multifactor cardiovascular disease (CVD) risk reduction program using team case management in high risk patients who have low family incomes and limited…
- Conditions
- Coronary Heart Disease, Stroke, Hyperlipidemia, Hypertension
- Trial name
- NCT00127751
- Testing
- Enhance health lifestyle changes and medication compliance
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Atrial Fibrillation, Heart Failure
Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients
Patients with heart failure (HF) represent a large population of patients who are at high risk for complications related to undiagnosed atrial fibrillation (AF).
- Trial name
- ASSERT-AF (NCT04818645)
- Testing
- ASSERT Insertable Cardiac Monitor, Conventional Management and monitoring
- Where
- United States
- Volunteers
- 477 people
- Sponsor
- University of Rochester
Cardiovascular Disease
The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and…
- Trial name
- SPIRE-1 (NCT01975376)
- Testing
- bococizumab (PF-04950615)
- Where
- 1,745 sites in United States, Argentina and 34 more
- Volunteers
- 16,784 people
- Sponsor
- Pfizer
Cardiac Death, Congestive Heart Failure
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
This is an observational study designed to monitor the course of the fraction of reticulated platelets and the correlation thereof to major adverse cardiac and cerebrovascular events after noncardiac surgery.
- Conditions
- Cardiac Death, Congestive Heart Failure, Angina Pectoris, Stroke
- Trial name
- NCT02097602
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Bleeding Disorder, Ischemic Stroke
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR)…
- Conditions
- Bleeding Disorder, Ischemic Stroke, Hemorrhagic Stroke, Hematological Diseases
- Trial name
- NCT03815175
- Testing
- XIENCE, DAPT (aspirin and/or P2Y12 receptor inhibitor)
- Where
- 111 sites in United States, Austria and 13 more
- Volunteers
- 1,605 people
- Sponsor
- Abbott Medical Devices