Clinical trials: High Sensitive C-reactive Protein (hsCRP)
Overweight (BMI > 25), Obesity (BMI>30)
Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.
The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in…
- Conditions
- Overweight (BMI > 25), Obesity (BMI>30), Hs-CRP
- Trial name
- NCT07566325
- Testing
- Avocado, Control
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Diabetes Mellitus
Effect of Sitagliptin and Empagliflozin in Combination With Metformin on Hs-CRP Levels in Patients With Type 2 Diabetes Mellitus
The goal of this clinical trial is to compare the effects of Sitagliptin and Empagliflozin in combination with metformin on High sensitivity C reactive proteins (hs-CRP) levels and efficacy in T2DM patients.
- Trial name
- NCT06952231
- Testing
- Sitagliptin + Metformin, Empagliflozin + Metformin
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Lahore
End-Stage Renal Disease, Inflammation
Channa Striatus Extract on Albumin and Hs-CRP ESRD
This study is a randomised, double blind, placebo-controlled study in patients with ESRD on HD or CAPD based RRTs at Moewardi General Hospital in Surakarta, Indonesia from January to March 2021.
- Trial name
- NCT05614362
- Testing
- Channa Striatus extract, Maltodextrin
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Sebelas Maret
Obesity, Elevated High-sensitivity C-reactive Protein (hsCRP)
A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity
This study is being done to look at the efficacy single and multiple ascending dose study investigating safety, tolerability, pharmacokinetics, food effect and target engagement in healthy adults including a single cohort in…
- Trial name
- NCT07693868
- Testing
- NNC6022-0004
- Where
- Netherlands
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Ischemic Stroke
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can play a role in preventing recurrent vascular events from ischemic heart disease patients, whose mechanism consists in not only the reduction of serum…
- Trial name
- NCT00361699
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 1,095 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Coronary Artery Disease, Atherosclerotic Cardiovascular Disease (ASCVD)
Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD)
This multicenter, randomized, open-label, noninferiority trial will compare two high-sensitivity C-reactive protein (hs-CRP) target-guided colchicine strategies in 1,768 adults with very-high-risk coronary artery disease after…
- Conditions
- Coronary Artery Disease, Atherosclerotic Cardiovascular Disease (ASCVD), Residual Inflammatory Risk
- Trial name
- NCT07920133
- Testing
- Colchicine (Colcrys®)
- Where
- China
- Volunteers
- 1,768 people
- Sponsor
- Sir Run Run Shaw Hospital
Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease
Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
The goal of this clinical trial is to compare low-dose colchicine (0.5 mg Once Daily) with no specific intervention in selected elderly patients (60-80 years old) with residual inflammatory risk (hs-CRP≥ 2mg/L) and multivessel…
- Conditions
- Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease, Elderly Patients, C-Reactive Protein
- Trial name
- RIGHT (NCT06025071)
- Testing
- colchicine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Apical Periodontitis, Coronary Artery Disease
hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis
Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary…
- Trial name
- NCT06270693
- Testing
- Endodontic treatment
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Diabetes Mellitus, Type 2
THE EFFECT OF LUMBRICUS RUBELLUS DLBS1033 EXTRACT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
This randomized, open-label, controlled trial aims to evaluate the effect of oral Lumbricus Rubellus extract DLBS1033 as adjunctive therapy on inflammatory biomarker (hs-CRP), angiogenic factor (VEGF), and quality of life in…
- Trial name
- NCT07684625
- Testing
- Oral Lumbricus Rubellus DLBS1033 (Low Dose), Oral Lumbricus Rubellus DLBS1033 (High Dose), Standard Diabetes Mellitus Therapy
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Sebelas Maret
ST Elevation Myocardial Infarction (STEMI), Malondialdehyde
Curcumin-Piperine Supplementation in STEMI - SPICE STEMI Trial
This study aims to evaluate whether supplementation with a combination of curcumin and piperine can help reduce inflammation and oxidative stress in patients who have experienced a heart attack called ST-Elevation Myocardial…
- Conditions
- ST Elevation Myocardial Infarction (STEMI), Malondialdehyde, Hs-CRP, Curcumin
- Trial name
- SPICE STEMI (NCT07149961)
- Testing
- Curcumin plus Piperine
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Diponegoro
Polycystic Ovary Syndrome, Periodontitis
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of…
- Conditions
- Polycystic Ovary Syndrome, Periodontitis, Insulin Resistance
- Trial name
- NCT02633462
- Testing
- scaling and root planing , Myo-inositol, Myo-inositol
- Volunteers
- 56 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Breast Cancer
Effect of Surgery, Radiation Therapy, Chemotherapy, and Hormone Therapy on Biomarkers in Women With Stage I, Stage II, Stage III Breast Cancer, or Ductal Carcinoma In Situ That Can Be Removed By Surgery
RATIONALE: Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00373191
- Testing
- chemotherapy, endocrine therapy, DNA methylation analysis
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Sepsis Syndrome, Emergency Department
Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department
This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly…
- Conditions
- Sepsis Syndrome, Emergency Department, Biomarker
- Trial name
- NCT06338111
- Testing
- ELISA Sepsis Biomarkers dosage
- Where
- Romania
- Volunteers
- 67 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Metabolic Disease
Husk Fiber Intervention on Metabolic Health of Centrally Obese School Teachers
A group of 120 school teachers (male=60, female=60) was divided into four subgroups for sixteen weeks of an interventional study. One group was kept in control while the other three groups were assigned intervention.
- Trial name
- NCT06188728
- Testing
- effect of 10 gm psyllium husk fiber twice a day, 30 minutes before breakfast and dinner, Effect of life style modification (Diet, Behavior and physical activity), Combined effect of 10 gm Psyllium husk fiber and lifestyle modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Peshawar
Body Mass Index Quantitative Trait Locus 8 Disorder, Tangier Disease
High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women
The investigators aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.
- Trial name
- NCT01763528
- Testing
- nutrition intervention
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Rheumatoid Arthritis, Vascular Inflammation
Etanercept in Rheumatoid Arthritis and Vascular Inflammation
The primary goal of this preliminary project is to study the effect of etanercept, a medicine approved by Health Canada for the treatment of rheumatoid arthritis, on the inflammation of certain blood vessels.
- Trial name
- NCT02109289
- Testing
- etanercept
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Innovaderm Research Inc.
hsCRP
Association Between Grade(B/C)of Stage III and IV Periodontitis and High Sensitivity C Reactive Protein Level in Serum and Oral Rinse Sample
According to 2017 World Workshop of Periodontology , the level of high sensitivity C reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at…
- Trial name
- NCT06997770
- Where
- India
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Two-Dimensional Echocardiography
The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
Objectives: To investigate the cardiac condition of the diabetic patients in our hospital in order to seek for the new diagnostic method of warning its cardiovascular complications in early times.
- Trial name
- NCT00940082
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Third Military Medical University
Stable Angina, Heart Failure
Association Between Inflammatory Biomarkers in CVD Patients on Empagliflozin.
The association of novel inflammatory biomarkers with cardiovascular diseases is still obscure. The present study aimed to investigate the relationship of various inflammatory biomarkers with the existence as well as the extent…
- Trial name
- NCT05911724
- Testing
- Group I Healthy, CAD-Empagliflozin 10 mg once daily for 6 months before the beginning of the study, HF-Empagliflozin 10 mg once daily for 6 months before the beginning of the study
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Damanhour University