Clinical trials: High-Flow Nasal Cannula
Desaturation of Blood
HFNC Versus Conventional Nasal Cannula in Oxygen Performance in Patients Receiving Colonoscopy Under IV Sedation
The purpose of this study is to investigate if high flow nasal cannula (HFNC), as compared to conventional nasal cannula, improves oxygenation and prevents desaturation events in obese patients undergoing colonoscopy.
- Trial name
- HFNC (NCT02968706)
- Testing
- High Flow Nasal Cannula, Conventional Nasal Cannula, Patient satisfaction questionnaire
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Aventura Hospital and Medical Center
High-Flow Nasal Cannula, COPD
Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypercapnic COPD
To test if high-flow conditioned oxygen therapy is noninferior to NIV for preventing postextubation respiratory failure and reintubation in patients with hypercapnic COPD, investigators plan to conduct the participants level, 1:1…
- Trial name
- COPD (NCT03928535)
- Testing
- High-FlowNasal Cannula, Noninvasive Ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Respiratory Failure, Congestive Heart Failure
Effect of High-flow Nasal Oxygen on Extubation Outcome
The purpose of this study is to determine whether high flow nasal cannula is effective in lowering the reintubation rate after extubation for high risk patients in medical intensive care unit
- Conditions
- Respiratory Failure, Congestive Heart Failure, COPD
- Trial name
- NCT02290548
- Testing
- high flow nasal cannula
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Mackay Memorial Hospital
Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome
Breastfeeding Infants Receiving Respiratory Support Trial
The purpose of this study is to assess whether two methods of breathing support in babies called 'Humidified High-Flow Nasal Cannula' oxygen (HHFNC) and 'nasal Continuous Positive Airways Pressure' (nCPAP) are compatible with…
- Conditions
- Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome, Continuous Positive Airway Pressure, Breast Feeding
- Trial name
- BIRRST (NCT02999165)
- Testing
- Breast feeding, Nasogastric feeding
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Imperial College Healthcare NHS Trust
Burn Injury, Hypoxia
Comparison of High Flow Nasal Oxygen and Nasal Cannula in Burn Patients Under Sedation
Burn-related pain is severe and often difficult to manage. Burn patients often require high doses of opioids and anxiolytics. Anesthetic agents used during sedation such as benzodiazepines, propofol and opioids can cause…
- Conditions
- Burn Injury, Hypoxia, Sedation
- Trial name
- NCT06756906
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara City Hospital Bilkent
Chronic Obstructive Pulmonary Disease
The Role of HNHF to Improve Clinical Outcomes Following Severe AECOPD
Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease, affecting 1.2 million people in the United Kingdom (UK). COPD patients suffer with episodes of worsening breathing symptoms called acute exacerbations…
- Trial name
- NCT03899558
- Testing
- Humidified nasal high-flow device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Healthy
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure.
- Trial name
- NCT05512585
- Testing
- awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy
Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters
The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured…
- Trial name
- HaFo (NCT04004247)
- Testing
- High Flow Nasal generator (AirVO2)
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Otorhinolaryngologic Surgical Procedures, Laser Therapy
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery
The purpose of this study is to investigate whether laser laryngeal surgery can be safely and potentially more effectively performed without the use of tracheal intubation or jet ventilation, under completely tubeless conditions.
- Trial name
- NCT03086265
- Testing
- THRIVE, Endotracheal tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation
The Physiological Effect of High Flow Oxygen Therapy
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or…
- Conditions
- High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT04212182
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD, Hypercapnic Respiratory Failure
HFNC vs NPPV After Early Extubation for Patients With COPD
High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with…
- Trial name
- NCT04156139
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 502 people
- Sponsor
- Chinese PLA General Hospital
Respiratory Insufficiency, Shock, Septic
Fluid Responsiveness in HFNC Patients
The plethysmographic variation index (PVi) is a measure of the respiratory-induced variations in the plethysmographic waveform. Interestingly, in mechanically ventilated patients and under certain conditions, PVi may reflect…
- Conditions
- Respiratory Insufficiency, Shock, Septic, Sepsis
- Trial name
- HIDRATE (NCT03817996)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Obstructive Pulmonary Disease
High Flow Nasal Cannula During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.
- Trial name
- NCT03237962
- Testing
- High Flow Nasal Cannula, Nasal Cannula
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung University
Respiratory Failure
The Efficacy of the Whisperflow CPAP System Versus Nasal High Flow in Patients at High Risk for Postextubation Failure
The purpose of this study is to compare the effect of continuous positive airway pressure (CPAP) delivered by the variable generator WhisperFlow System with high flow nasal cannula oxygen therapy in mechanically ventilated…
- Trial name
- NCT02918786
- Testing
- Nasal high-flow, CPAP
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Ramathibodi Hospital
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Patient Population Submitted to ERCP
High Flow Nasal Cannula in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) HF-study
The expected results with this study are that high flow devices (LAF) provide adequate respiratory support during the performance of ERCP under deep sedation, reducing episodes of desaturation, hypoventilation and airway…
- Trial name
- HFS (NCT04082208)
- Testing
- High Flow nasal cannula, Low Flow nasal cannula
- Where
- Spain
- Volunteers
- 172 people
- Sponsor
- Hospital Clinic of Barcelona
High Flow Nasal Cannula
Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula
High-humidity nasal cannula (HFNC) has been shown to be effective in improving oxygenation and avoiding intubation in multiple randomized control trials, it is also suitable and feasible for long term use.
- Trial name
- NCT03091504
- Testing
- High flow nasal cannula, Albuterol Sulfate
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center