Clinical trials: High-Flow Nasal Cannula
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
High-altitude Pulmonary Edema
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in Children High-altitude Pulmonary Edema
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in children with High-Altitude Pulmonary Edema (HAPE).
- Trial name
- NCT07910357
- Testing
- High-flow Nasal Cannula Oxygen Therapy (HFNC)
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Ye Fan
Chronic Obstructive Pulmonary Disease, High-flow Nasal Cannula
High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during…
- Trial name
- OPTINEB (NCT03449056)
- Testing
- salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Morbid Obesity
Nasal High Flow in Bariatric Surgery
High frequency nasal cannula (HFNC) provides an inspiration O2 fraction of 21-1% and it has a minimal dead space and can be well tolerated due to humidified air.
- Trial name
- NCT04048798
- Testing
- Oxygen therapy via HFNC, Oxygen therapy via face mask
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Care, Palliative, Respiratory Failure
RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF
Randomized clinical trial in which the main objective is to compare High Flow Nasal Cannula (HFNC) versus the standard respiratory care in the alleviation of dyspnea perception in patients with do-not-intubate (DNI) order.
- Trial name
- NCT04269681
- Testing
- High Flow Nasal Cannula, Standard respiratory support
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Hospital do Coracao
Hypoxemia
The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients
High flow nasal cannula (HFNC) delivers oxygen at a flow which exceeds the patient's inspiratory flow demand in order to improve oxygenation.
- Trial name
- NCT03738345
- Testing
- HFNC flow
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease Moderate, Obesity
Aerosol Therapy in Obese COPD Patients.
This study has the objective to clarify the factors that directly influence the effectiveness of inhaled drug deposition in obese patients with chronic obstructive pulmonary disease (COPD) and suggest the use of High Flow Nasal…
- Trial name
- NCT03031093
- Testing
- inhalation protocol, High Flow Nasal Cannula
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Respiratory Failure
High Flow Nasal Cannula Versus Non-invasive Ventilation in Prevention of Escalation to Invasive Mechanical Ventilation in Patients With Acute Hypoxemic Respiratory Failure
Oxygen therapy is first-line treatment in the management of acute respiratory failure (ARF). Different oxygen devices have become available over recent decades, such as low-flow systems (nasal cannula, simple facemask…
- Trial name
- NCT03788304
- Testing
- non-invasive ventilation, high flow nasal cannula
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hypoxemia
Procedural Oxygen Mask vs. High-flow Nasal Cannula for Hypoxemia Prevention During ERCP
Endoscopic retrograde cholangiopancreatography (ERCP) is an imaging procedure that visualizes the drainage ducts of the pancreas, gallbladder, and liver through the use of a duodenoscope and contrast media.
- Trial name
- NCT06817603
- Testing
- Procedural Oxygen Mask, High-Flow Nasal Cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Kocaeli City Hospital
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Desaturation
Effect of High Flow Nasal Cannula on Oxygenation During Urodynamic Study in Pediatric Population
To evaluate the effect of high flow nasal cannula for prevention of hypoxia during deep sedation in pediatric population
- Trial name
- NCT04152733
- Testing
- High flow nasal cannula
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Seoul National University Hospital
Respiratory Disease, Newborn Rds
Premature Newborns Treated With Less Invasive Surfactant Administration Under Heated Humidified High-flow
Nasal Continuous Airway Pressure (CPAP) or Heated humidified high-flow Air support with nasal cannula (HHHFNC) are among the most commonly used non-invasive respiratory support methods.
- Trial name
- NCT06398691
- Testing
- Nazal CPAP, Heated humidified high-flow air support with nasal cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
High-Flow Nasal Cannula, Oxygen Therapy
Individualization Flow in Patients Treated With High Flow Nasal Therapy (iFLOW)
In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decreases work of breathing as compared to standard oxygen therapy by facemask.
- Conditions
- High-Flow Nasal Cannula, Oxygen Therapy, Acute Respiratory Failure, Respiratory Failure
- Trial name
- iFLOW (NCT05401474)
- Testing
- High Flow Nasal Cannula at 30L/min, High Flow Nasal Cannula at 45L/min, High Flow Nasal Cannula at 60L/min
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hypoxemic Respiratory Failure
A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Our main objective is to collect feasibility data on helmet NIPPV and other clinical elements in to eventually prepare for a full scale randomized trial based on findings of this pilot study.
- Trial name
- NOVA-pilot (NCT04035460)
- Testing
- Helmet, High Flow Nasal Oxygen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baystate Medical Center
Respiratory Insufficiency
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
Procedural sedation is an established and safe intervention and is widely used in diagnostic and therapeutic procedures for pediatric patients.
- Trial name
- HiFiPPS (NCT02930525)
- Testing
- High Flow nasal cannula, Standard respiratory care
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Freiburg
Bronchiolitis
Study of High-flow Oxygen Therapy Against Standard Therapy in Bronchiolitis
Bronchiolitis is a common illness of the respiratory tract caused by infection of the tiny airways within the lungs called bronchioles.
- Trial name
- Hi-Flo (NCT01498094)
- Testing
- High Flow Nasal Cannula Oxygen Therapy, Standard low flow oxygen
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- University of British Columbia
Extubation Failure
Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients
Extubation failure is associated with increased morbidity and mortality in critically ill patients. High-risk patients may benefit from preventive respiratory support after extubation.
- Trial name
- NIV-HFNC (NCT07630766)
- Testing
- NIV, HFNC
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Benha University
COPD
HFNC During Bronchoscopy in COPD Patients
Bronchoscopy diagnosis and treatment is highly irritating, and the effect of local topical anesthesia is poor; the airway is shared; and COPD patients have low oxygen reserves due to impaired lung function.
- Trial name
- HFNC COPD (NCT07850856)
- Testing
- group N used traditional nasal cannula for oxygen inhalation, Group HFNC used nasal high-flow oxygen inhalation.
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Oxygen Deficiency
HFNC vs Two Nare HFNC in Extubated Patients
High flow nasal cannula (HFNC) are introduced to clinical practice to improve oxygenation. Our group were the first to report the use of HFNC in extubated patients that showed comparable delivery of oxygen and improved comfort.
- Trial name
- HFNC (NCT06398951)
- Testing
- Two nare high flow nasal cannula
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Peninsula Health