Clinical trials: High-Flow Nasal Cannula Therapy
Acute Respiratory Failure
High Flow Therapy for the Treatment of Respiratory Failure in the ED
The overall objective of this study is to determine if Vapotherm high flow nasal cannula therapy (HFT), when used to treat respiratory failure in the ED, is at least equivalent to the current standard of care for non-invasive…
- Trial name
- NCT02236559
- Testing
- Noninvasive positive pressure ventilation (NIPPV), Vapotherm
- Where
- 5 sites in United States
- Volunteers
- 204 people
- Sponsor
- Vapotherm, Inc.
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Chronic Obstructive Pulmonary Disease (COPD)
High-flow Nasal Cannula Therapy for Stable Chronic Obstructive Pulmonary Disease (COPD)
This is a prospective, randomized crossover study for evaluation of the efficacy and safety of long-term nocturnal high-flow nasal cannula therapy with the myAIRVO2® in stable COPD patients with stage 2-4 of the Global Initiative…
- Trial name
- NCT02545855
- Testing
- High-flow nasal cannula therapy, Home oxygen therapy (HOT)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Intensive Care Unit, Mechanical Ventilation
Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients
Dexmedetomidine and ketamine are both suggested for sedation and analgesia in ICU patients. Recent studies suggest that low-dose dexmedetomidine or ketamine/esketamine may improve sleep quality of ICU patients.
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Dexmedetomidine, Esketamine
- Trial name
- NCT05718024
- Testing
- Dexmedetomidine-esketamine, Routine sedation and analgesia
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking University First Hospital
Hypoxemia
Comparative Study on the Effectiveness, Comfort and Compliance of HFNC and Noninvasive Mechanical Ventilation BiPAP Mode in the Treatment of Hypoxemia Patients
Patients who met the inclusion criteria were included and signed an informed consent form, which complied with the requirements of the ethics committee of our unit. All subjects were inpatients.
- Trial name
- NCT05784636
- Testing
- Non-invasive BiPAP ventilation, HFNC
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Qilu Hospital of Shandong University
Cerebral Infarction, Sleep Apnea, Obstructive
High-flow Nasal Cannula Oxygen Therapy for Ischemic Stroke Patients With Dysphagia and Obstructive Sleep Apnea
High flow nasal cannula (HFNC) ventilation therapy was found to improve the severity of obstructive sleep apnea in non-stroke subjects.
- Conditions
- Cerebral Infarction, Sleep Apnea, Obstructive, Deglutition Disorders
- Trial name
- NCT04173767
- Testing
- high flow nasal cannula ventilation
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Chang Gung Memorial Hospital
Airway Extubation, Oxygen Inhalation Therapy
High Flow Nasal Cannula in Immediately Post Extubation
The aim of the study is to determine the incidence of failure of extubation in high-risk patients using High Flow Nasal Cannula (HFNC) to prevent such failure in the Intensive Care Unit. A prospective cohort study was performed.
- Trial name
- HFNC (NCT03495947)
- Testing
- high flow nasal cannula
- Where
- Argentina
- Volunteers
- 165 people
- Sponsor
- Hospital Italiano de Buenos Aires
Patients With Respiratory Insufficiency
High Flow Nasal Cannulae Oxygen Therapy in Respiratory Insufficiency Patients
Chronic respiratory insufficiency in patients with advanced disease to the late treatment depends mainly on mechanical ventilation and other high intensity respiratory support therapy.
- Trial name
- NCT02972021
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Premature Infant, Ventilation Therapy
High Flow Nasal Cannula for Stabilization of Extremely Premature Infants
A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth.
- Conditions
- Premature Infant, Ventilation Therapy, High Flow Nasal Canula
- Trial name
- SIMPLSAFE2 (NCT06683677)
- Testing
- High-Flow Nasal Cannula
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Bronchiolitis, Pneumonia
Airway Pressure During Humidified High Flow Nasal Cannula Therapy in Children
Humidified High Flow Nasal Cannula (HHFNC) is a new modality of respiratory support for children with respiratory failure. Despite its extensive use in pediatric and adult population, the exact mechanism of work of HHFNC is not…
- Conditions
- Bronchiolitis, Pneumonia, Bronchial Asthma
- Trial name
- NCT02387632
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Respiratory Failure
The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure
High flow nasal cannula (HFNC) oxygen therapy is increasingly used for hypoxemic respiratory failure and is proving useful in avoiding or delaying intubation and mechanical ventilation.
- Trial name
- NCT05708287
- Testing
- HFNC
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Hadassah Medical Organization
Respiratory Failure, Respiratory Insufficiency
Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Tract Diseases, COPD
- Trial name
- NCT03443479
- Testing
- Non-Invasive Ventilation, High-Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Hôpital de Verdun
Sleep Apnea, Obstructive
High Flow Nasal Cannula as a Treatment for Obstructive Sleep Apnea
A single center, prospective study to assess the efficacy of high flow nasal cannula (HFNC) in improving obstructive sleep apnea (OSA) parameters in patients with reduced tolerance to continuous positive airway pressure (CPAP)…
- Trial name
- NCT03017859
- Testing
- High flow nasal cannula
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation
The Physiological Effect of High Flow Oxygen Therapy
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or…
- Conditions
- High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT04212182
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Acute Hypoxemic Respiratory Failure, High-flow Nasal Cannula Oxygen
Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy
Acute respiratory failure (AFR) is a serious condition that requires prompt and appropriate intervention to prevent further deterioration and improve outcomes.
- Trial name
- NCT05759832
- Testing
- Modified HFNC oxygen therapy, Non-rebreathing reservoir mask
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Beijing Chao Yang Hospital
Respiratory Insufficiency, Pneumonia
High Flow Nasal Cannulae vs Venturi Mask in Respiratory Failure Due to Pneumonia
The primary objective of this study is to compare the efficacy of treatment with HFNC (group A) compared to administration of oxygen therapy by Venturi mask (group B, standard therapy) in terms of reaching of endotracheal…
- Trial name
- HiFlOViP (NCT03515031)
- Testing
- High Flow Nasal Cannula Oxygenation, Venturi Mask Oxygenation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Papa Giovanni XXIII Hospital
COPD, Rehabilitation
High-flow Nasal Cannula and Exercise Tolerance in COPD
Patients with COPD are often unable to sustain a sufficient workload during exercise. The use of external strategies to improve exercise tolerance, such as non-invasive ventilation (NIV) and high-flow nasal therapy (HFNT) have…
- Conditions
- COPD, Rehabilitation, Exercise
- Trial name
- NCT04350970
- Testing
- High flow nasal therapy, Non-invasive ventilation, Control
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Marcelo Alcantara Holanda
Bronchiolitis, Respiratory Syncytial Virus (RSV)
High Flow Nasal Cannula Therapy in Bronchiolitis : Early vs Rescue
The enrolled RSV-bronchiolitis patients will be randomized into two arms , the early HHHFNC group and the standard therapy group with rescue HHHFNC to study the efficacy of this treatment.
- Trial name
- NCT03095495
- Testing
- Heated Humidified High Flow Nasal Cannula, Standard Therapy (Low Flow Nasal Cannula)
- Where
- Qatar
- Volunteers
- 28 people
- Sponsor
- Hamad Medical Corporation
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Extubation Failure, Prematurity
Comparing HHHFNC and nCPAP Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants
Purpose is to show that HHHFNC method is as effective and safe as nCPAPand even more comfortable than it as non-invasive respiratory support for the prevention of extubation failure in preterm with gestational age of 26-32 weeks.
- Trial name
- NCT02887846
- Testing
- Heated Humidified High-Flow Nasal Cannula
- Volunteers
- 200 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital