Clinical trials: High-Flow Nasal Oxygen Therapy
Pneumonia-associated Acute Hypoxemic Respiratory Failure
Non-invasive Ventilation Versus High Flow Oxygen
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute…
- Trial name
- HFO (NCT03758508)
- Testing
- High Flow Oxygen nasal cannula, Noninvasive ventilation
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Niguarda Hospital
Intubation, Cardiovascular Surgical Procedure
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac surgery decreases the…
- Trial name
- NCT04782817
- Testing
- Recommendation for high flow nasal cannula oxygen therapy order set, Provider choice usual care order set
- Where
- United States
- Volunteers
- 3,568 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia
HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen (HFNO) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (AHRF).
- Trial name
- NCT05809089
- Testing
- High flow nasal cannula (HFNC), Noninvasive ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
High-flow Nasal Cannula Oxygen
Evaluating High-flow Nasal Cannula Oxygen Therapy Through LUS During Weaning
Respiratory distress after extubation is associated with increased morbidity and mortality. Its multifactorial pathophysiology causes a loss of pulmonary aeration during the weaning process, the clinical translation being…
- Trial name
- NCT03384394
- Testing
- high-flow nasal cannula oxygen, Conventional oxygen therapy
- Volunteers
- 250 people
- Sponsor
- lu xiao
Acute Respiratory Failure
Brain-lung Interaction During Acute Respiratory Failure
Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia.
- Trial name
- BrainFlow (NCT07279831)
- Testing
- EEG/NIRS/EMG
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laryngeal Disease
Comparison of Two Ventilation Methods for Micro-Laryngeal Surgery
Single-center, randomized study, comparing two methods of oxygenation on 80 patients
- Trial name
- Ventinova ORL (NCT04369040)
- Testing
- High-flow nasal oxygen therapy using a specific nasal cannula, Flow Controlled Ventilation using a laryngeal tri-tube
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Hopital Foch
Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome
Breastfeeding Infants Receiving Respiratory Support Trial
The purpose of this study is to assess whether two methods of breathing support in babies called 'Humidified High-Flow Nasal Cannula' oxygen (HHFNC) and 'nasal Continuous Positive Airways Pressure' (nCPAP) are compatible with…
- Conditions
- Intensive Care, Neonatal, Neonatal Respiratory Distress Syndrome, Continuous Positive Airway Pressure, Breast Feeding
- Trial name
- BIRRST (NCT02999165)
- Testing
- Breast feeding, Nasogastric feeding
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Imperial College Healthcare NHS Trust
COPD, Chronic Hypercapnic Respiratory Failure
Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics
Nasal High Oxygen Flow (HOF) has been demonstrated to reduce the re-intubation rate in hypoxic patients and ameliorate breathing pattern in hypercapnic patients.
- Trial name
- NCT02363920
- Testing
- HOF, noninvasive mechanical ventilation (NIV)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Healthy Volunteers
Gas Composition in the Oropharynx During High-flow Oxygen Therapy Through Nasal Cannula in Healthy Volunteers
Observational, randomized studies and their meta-analyses have shown the high effectiveness of high-flow oxygen therapy through nasal cannulas, reaching 50-60% in acute hypoxemic respiratory failure.
- Trial name
- NCT06189716
- Testing
- High flow oxygen through nasal cannula
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Electroconvulsive Therapy Treated Patients, Obesity
LMA vs High-flow Nasal Oxygen During ECT in Obese Patients
This study aims to compare two oxygenation strategies-laryngeal mask airway (LMA) ventilation and high-flow nasal cannula (HFNC)-during electroconvulsive therapy (ECT) in obese patients.
- Trial name
- NCT07093372
- Testing
- Laryngeal Mask Airway, High-Flow Nasal Cannula
- Volunteers
- 25 people
- Sponsor
- Eulji University Hospital
Pulmonary Disease, Chronic Obstructive
High-Flow Nasal Oxygen Therapy for Exacerbation of Chronic Pulmonary Obstructive Disease.
High-Flow Nasal Oxygen (HFNO) therapy has never been tested against Noninvasive ventilation, the reference standard therapy for acute exacerbation of chronic obstructive pulmonary disease (COPD), in randomized clinical trials.
- Trial name
- OxyCOD (NCT03488628)
- Testing
- Noninvasive ventilation, High-Flow Nasal Oxygen therapy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Hypoxemia, Pneumonia
Effect of High-Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Pediatric Sedated Bronchoscopy
Due to children's lower oxygen reserves and higher oxygen consumption, sedation can easily lead to respiratory adverse events such as hypoxemia.
- Conditions
- Hypoxemia, Pneumonia, Pulmonary Neoplasm
- Trial name
- NCT07563075
- Testing
- High-flow nasal cannula, Regular Nasal Cannula
- Where
- 4 sites in China
- Volunteers
- 430 people
- Sponsor
- Zhejiang University
Post Operative Pulmonary Complications
HFNC Versus Oxygen Face Mask on Postoperative Pulmonery Complications
Eighty adult patients were randomly categorized into two equal groups (forty patients each): HFNC was applied to group I, and a simple oxygen face mask was applied to group II.
- Trial name
- NCT05548309
- Testing
- HFNC, Oxygen face mask
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Alexandria University
Cardiac Valve Disease, Coronary Artery Disease
Nasal Oxygen Therapy After Cardiac Surgery
NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation, inclusive of up to one hour off randomised therapy for transfers around the hospital and/or physio…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Respiratory Failure
- Trial name
- NOTACS (NCT05308719)
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 1,280 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Respiratory Failure, Post Extubation Acute Respiratory Failure Requiring Reintubation
Effect of HFNO Therapy on Respiratory Effort After Extubation
Rationale: Despite the lack of clear clinical protocols, High Flow Nasal Oxygen (HFNO) is used as post-extubation respiratory support.
- Trial name
- T-REX (NCT05652699)
- Testing
- High Flow Nasal Oxygen, Conventional Oxygen Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people
- Sponsor
- Henrik Endeman
Hypercapnic Respiratory Failure
High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure
this study evaluates high flow oxygen therapy in addition to non invasive ventilation (NIV) to treat hypercapnic respiratory failure.
- Trial name
- NCT03627598
- Testing
- HFNC, standard
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Mahdia
Post Extubation Respiratory Failure, Re-intubation
Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients
Post extubation respiratory failure occur in 30% of extubated patients. More than 50% of them required reintubation. Noninvasive positive pressure ventilation (NIV) had been reported as an effective tool to prevent post…
- Conditions
- Post Extubation Respiratory Failure, Re-intubation, Septic Shock, Severe Sepsis
- Trial name
- NCT03246893
- Testing
- Noninvasive positive pressure ventilation, High flow oxygen nasal cannula
- Where
- Thailand
- Volunteers
- 222 people
- Sponsor
- Mahidol University
Hypoxemic Respiratory Failure
Flow Rates of High-flow Nasal Cannula and Extubation Outcome
This is a single-center, open-label, randomized controlled trial to evaluate the effect of high-flow nasal cannula with a flow rate of 60 L/min versus 40 L/min after planned extubationon on a composite outcome of reintubation and…
- Trial name
- NCT04934163
- Testing
- Flow rate setting of high-flow nasal cannula (initially 60L/min), Flow rate setting of high-flow nasal cannula (initially 40L/min)
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Respiratory Failure, Congestive Heart Failure
Effect of High-flow Nasal Oxygen on Extubation Outcome
The purpose of this study is to determine whether high flow nasal cannula is effective in lowering the reintubation rate after extubation for high risk patients in medical intensive care unit
- Conditions
- Respiratory Failure, Congestive Heart Failure, COPD
- Trial name
- NCT02290548
- Testing
- high flow nasal cannula
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Mackay Memorial Hospital