Clinical trials: High-Risk Cancer
Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers
Targeted Abdominal CT in Conjunction With Lung Cancer Screening
Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers, AAA - Abdominal Aortic Aneurysm, Renal Stones
- Trial name
- TACTICAL1 (NCT07171190)
- Testing
- Lung Cancer Screening Invitation Intervention, Abdominal scan intervention
- Where
- United Kingdom
- Volunteers
- 6,272 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Neoplasms
Chest Imaging of Lung Nodule(s) Under High-frequency Non-invasive Ventilation (HF-NIV)
Imaging of chest disorders is mainly achieved by using computed tomography. This is especially the case for detection, morphologic assessment and followup of pulmonary nodules.
- Trial name
- NCT03553368
- Testing
- HF-NIV-MR, HF-NIV-PET, MR
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Neoplasm, Colorectal, Neoplasm, Breast
Development, Implementation and Evaluation of an Individual Decision Aid in Swedish Cancer Screening Programs
Background: Sweden has a long tradition of organized national population-based screening programs. Participation rates differ between programs and regions, are relatively high in some groups, but lower in other.
- Conditions
- Neoplasm, Colorectal, Neoplasm, Breast, Neoplasm, Ovarian
- Trial name
- BESTa (NCT05512260)
- Testing
- Individual decision aid (iDA)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers
This pilot research trial studies the antibody response to high-dose seasonal influenza vaccination in patients with myeloid malignancy receiving chemotherapy and healthy volunteers.
- Trial name
- NCT04484532
- Testing
- Trivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Breast Cancer
Dietary Fish and Omega 3 Fatty Acids for Breast Cancer Prevention
Research studies show that the type of fat in the diet may affect breast cancer risk. Fish oil and fish contain increased amounts of omega 3 fatty acids which appear to stop or slow down the growth and development of breast…
- Trial name
- NCT01282580
- Testing
- Lovaza-Omega 3 fatty acid capsules, Dietary fish (canned salmon, albacore)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Risk for Colorectal Cancer
Evaluation C-Scan System in Providing Structural Information and Polypoid Lesions in the Colon of Healthy Subjects
Up to 300 subjects will participate in this study. Subjects to be enrolled in this study are typically healthy and at average or high risk for CRC.
- Trial name
- CRC (NCT04038736)
- Testing
- C-Scan System
- Where
- 4 sites in Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Breast Cancer
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
The investigators will study the effect of 12 months of SDG (Brevail) vs placebo on women at increased risk for development of breast cancer.
- Trial name
- NCT01276704
- Testing
- secoisolariciresinol
- Where
- 7 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Polycystic Ovary Syndrome
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water…
- Trial name
- MRI-PCOS (NCT03043924)
- Testing
- Cyproterone Acetate + estradiol, Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Gastric (Stomach) Cancer, Helicobacter Infection
An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori
This study is intended to be a prospective observational cohort study. The incidence of gastric cancer and progression of gastric precancerous lesions will be compared between groups through prospective follow-up of a population…
- Trial name
- NCT06896370
- Testing
- observational study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome and Cabergoline
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I)…
- Trial name
- NCT01569256
- Testing
- Cabergoline
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Anal Cancer, Nonneoplastic Condition
Comparing Two Types of Swabs in Collecting Cell Samples for Anal Pap Tests and Human Papillomavirus Tests in Men Who Have Sex With Men
RATIONALE: Doctors use a swab to collect cell samples when testing for anal cancer and human papillomavirus. It is not yet known which type of swab is more effective in collecting cell samples for anal Pap tests and human…
- Conditions
- Anal Cancer, Nonneoplastic Condition, Precancerous Condition
- Trial name
- NCT00955591
- Testing
- Papanicolaou test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Non-Hodgkin's Lymphoma, Acute Leukemia in Remission
Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT
The purpose of this study is to find out if a combination of drugs (these are called: cyclophosphamide, sirolimus, and mycophenolate mofetil) will protect participants better against graft vs.
- Conditions
- Non-Hodgkin's Lymphoma, Acute Leukemia in Remission, Chronic Myeloid Leukemia, Primary Myelofibrosis
- Trial name
- NCT03018223
- Testing
- Fludarabine, Busulfan, Cyclophosphamide
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Sunburn, Erythema, Sun Protection
UV Exposure Assessed With Wearable Sensor and Sun Protection
The goal is to prevent ultraviolet light (UV) overexposure by providing consumers with relevant, easy-to-access, specifically actionable information.
- Trial name
- NCT03344796
- Testing
- Goal attainment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HPV Infection
HPV Vaccine Immunity in High-risk Women
This is a single arm immunological study based in Vietnam. The study will examine human papillomavirus (HPV) vaccine responses in high-risk women (female-sex-worker; FSW).
- Trial name
- NCT04590521
- Testing
- Gardasil®, Merck
- Where
- Vietnam
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Colon Cancer Prevention
Exploring the Effects of a High Chlorophyll Dietary Intervention to Reduce Colon Cancer Risk in Adults
Colon cancer is the third most common cancer in men and women and over 70% of cases are preventable. A western diet, characterized by low vegetable and high red and processed meat intake, indisputably increases colon cancer risk.
- Trial name
- M3G (NCT03582306)
- Testing
- High chlorophyll diet - intervention 1st, High chlorophyll diet - control 1st
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Auburn University
Lung Cancer
Implementing Fragmentomics Into Real World Screening IntervenTions to Evaluate Clinical Utility Among Individuals With Elevated Risk for Lung Cancer
The purpose of this study is to determine whether availability of DNA Evaluation of Fragments for Early Interception (DELFI) Lung Cancer Screening Test, FirstLook™ to practicing physicians affects overall lung cancer screening…
- Trial name
- FIRSTLUNG (NCT06145750)
- Testing
- Ability to order FirstLook™, Continuing Medical Education for Lung Cancer
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Delfi Diagnostics Inc.
Education, Medical
Implementation of Anal Cancer Screening and Treatment in Nigeria
The study is a feasibility pilot trial testing 2 types of training protocols on a single physician. The first training protocol is the current standard and was developed in high-income settings.
- Trial name
- IMPACT (NCT05817370)
- Testing
- Enhanced Training on screening and treatment of HSIL (e-STH)
- Where
- Nigeria
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Gd-based Contrast Media Exposure During Breast MRI Scans
Evaluation of Gadolinium Deposits in Healthy Women Participating in a High Risk Screening Program for Early Breast Cancer Detection
Purpose: To determine whether patients at high risk to develop breast cancer having received at least 6 cumulative dosages of macrocyclic Gd-based contrast media in the context of breast cancer screening by means of…
- Trial name
- NCT03393442
- Testing
- Brain MRI scan
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gastric Adenocarcinoma, Early Gastric Cancer
A Multicentre Observational Cross-Sectional Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy And Histopathology In India
To estimate the prevalence of histologically confirmed early gastric cancer (EGC) in an Indian multicentre cohort undergoing standardised high-quality upper gastrointestinal endoscopy.
- Trial name
- IND-PREP (NCT07486518)
- Where
- India
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India