Clinical trials: High-Risk Cancer
Breast Cancer
Dietary Fish and Omega 3 Fatty Acids for Breast Cancer Prevention
Research studies show that the type of fat in the diet may affect breast cancer risk. Fish oil and fish contain increased amounts of omega 3 fatty acids which appear to stop or slow down the growth and development of breast…
- Trial name
- NCT01282580
- Testing
- Lovaza-Omega 3 fatty acid capsules, Dietary fish (canned salmon, albacore)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anal Carcinoma, HIV Infection
Anal Cytology Collection Procedures in Predicting High-Grade Anal Dysplasia in Men Who Have Sex With Men
This clinical trial compares three anal cytology collection procedures (collected at a single visit) in men who have sex with men (MSM).
- Conditions
- Anal Carcinoma, HIV Infection, Human Papillomavirus Infection
- Trial name
- NCT02816879
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Lung Neoplasms, Stomach Neoplasms
Default Option Nudging Intervention to Improve the Adherence Rates of Cancer Screening
The goal of this clinical trial is to learn if a behavioral "nudge" strategy, specifically a default option, can improve screening participation in populations at high risk for lung and stomach cancer.
- Conditions
- Lung Neoplasms, Stomach Neoplasms, Early Detection of Cancer, Patient Compliance
- Trial name
- NCT07682220
- Testing
- Default Options
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
Gd-based Contrast Media Exposure During Breast MRI Scans
Evaluation of Gadolinium Deposits in Healthy Women Participating in a High Risk Screening Program for Early Breast Cancer Detection
Purpose: To determine whether patients at high risk to develop breast cancer having received at least 6 cumulative dosages of macrocyclic Gd-based contrast media in the context of breast cancer screening by means of…
- Trial name
- NCT03393442
- Testing
- Brain MRI scan
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Esophageal Squamous Cell Carcinoma, Dysplasia
Efficacy of Endoscopy Screening on Esophageal Cancer in China (ESECC)
To evaluate the efficacy of endoscopic screening on esophageal cancer (EC) and determine the most cost-effective strategy of endoscopic screening in high risk population in China, 668 villages of Hua county, a high risk area of…
- Trial name
- ESECC (NCT01688908)
- Testing
- Endoscopic Screening
- Where
- China
- Volunteers
- 33,948 people, healthy volunteers welcome
- Sponsor
- Peking University
Human Papilloma Virus (HPV)
Evaluation of the Cobas® 4800 HPV Test for the Detection of High-grade Cervical Disease
This study provided data on the performance of the Cobas® 4800 HPV Test for identifying histologically confirmed high-grade cervical disease.
- Trial name
- NCT00709891
- Testing
- cobas® 4800 HPV Test
- Where
- 61 sites in United States
- Volunteers
- 47,208 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Polyps
Experience and Enhancement: Improving Colonoscopic Polyp Detection
The study looks at 2 hypotheses in 2 patient groups: 1. Are more experienced endoscopists better at detecting subtle lesions (polyps) on the lining of the colon (large bowel) than less experienced endoscopists? 2.
- Trial name
- NCT00237276
- Testing
- colonoscopy
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Breast Cancer
Protocol for Women at Increased Risk of Developing Breast Cancer
To assess the effects of twelve months of celecoxib administration by evaluating breast tissue needle aspirations, to determine if cell growth can be slowed.
- Trial name
- NCT00291694
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Gastric Cancer
A Randomized Study Comparing Autofluorescence Imaging(AFI) Followed by Narrow Band Imaging(NBI) With Videoendoscopy for the Detection of High Risk Lesions of Stomach
Videoendoscopy is the standard tool for examination of gastrointestinal tract. However, precancerous lesions and early gastric cancer can be easily missed by routine videoendoscopy.
- Trial name
- CAFBI (NCT01132534)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Risk for Colorectal Cancer
Evaluation C-Scan System in Providing Structural Information and Polypoid Lesions in the Colon of Healthy Subjects
Up to 300 subjects will participate in this study. Subjects to be enrolled in this study are typically healthy and at average or high risk for CRC.
- Trial name
- CRC (NCT04038736)
- Testing
- C-Scan System
- Where
- 4 sites in Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Gene Mutation-Related Cancer, Genetic Predisposition
Genetic Information Assistant in Telegenetics
The goal of this clinical trial is to learn about different ways cancer genetic screening can be provided to rural communities in participants at high risk for certain cancers.
- Trial name
- NCT06089421
- Testing
- Genetic Information Assistant, Telegenetics with UVA genetic counselor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cancer Risk
CanScan; Community-based Registry to Assess, Address and advaNce SCreening for cANcer Prevention and Management
Early diagnosis of cancer allows for better treatment outcomes, higher survival rates, and lower costs of care. It is shown that cancer monitoring for cancer in at-risk populations is a key component in early diagnosis.
- Trial name
- NCT06804395
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Colorectal Adenoma, Colorectal Polyp
To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age
The aim of this study is to assess the efficacy of Ultivision Artificial Intelligence (AI) Software in detecting adenomas in screening colonoscopy procedures. The safety of Ultivision AI Software will also be assessed.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal SSA
- Trial name
- AIDA (NCT04196088)
- Testing
- Ultivision Artificial Intelligence Software, No Artificial Intelligence Software enhancement
- Where
- 9 sites in United States
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Docbot, Inc.
Breast Cancer
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy in Screening Women at Moderate-to-High Risk of Developing Breast Cancer
RATIONALE: Screening tests, such as nipple aspiration, ductal lavage, and breast duct endoscopy, may help doctors detect cancer cells early and plan more effective treatment for breast cancer.
- Trial name
- NCT00081003
- Testing
- gene expression analysis, protein expression analysis, cytology specimen collection procedure
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Gastric Cancer
Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer（RC48-C018）
This trial is a multi-center, open, single-arm, superior phase II clinical study.
- Trial name
- NCT05113459
- Testing
- Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guoxin Li
Malignant Tumor
Pharmacokinetic Test of High-fat Diet After Oral Administration of SHR2554 in Healthy Subjects
The objective of the study is to assess the effect of food on the pharmacokinetics, and safety of SHR2554 Tablets in healthy subjects.
- Trial name
- NCT05592262
- Testing
- SHR2554
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Colorectal Cancer
Barriers to Care in Patients With Rectal Bleeding in Nigeria
This study sought to find the health seeking behavior of patients with rectal bleeding as related to their risk to develop colorectal cancer and also assess the general practitioner's perceived barriers to colonoscopy for…
- Trial name
- NCT02855385
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Colorectal Cancer
I-Scan Vs High Definition White Light (Main Study)
The purpose of this study is to assess whether the use of I-Scan during colonoscopy leads to an increased yield of adenomas in the colon among a population at increased risk for CRC.
- Trial name
- NCT02016326
- Testing
- HD Colon, I-scan 1, I-Scan 2
- Where
- Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Calgary