Clinical trials: High-Risk Cancer
Breast Cancer
Green Tea and Reduction of Breast Cancer Risk
RATIONALE: Green tea extract contains ingredients (catechins) that may lower the risk of breast cancer. PURPOSE: This phase II trial is studying how well green tea extract works in preventing breast cancer compared to a placebo…
- Trial name
- NCT00917735
- Testing
- Green tea extract supplement
- Where
- 5 sites in United States
- Volunteers
- 1,075 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Head And Neck Cancer, Oropharynx Cancer
OraTest in Combination With Visual Examination and Visual Examination Alone
Primary Objectives: 1. To assess the ratio in sensitivities of OraTest® in combination with visual examination versus visual examination alone in the detection of serious pathology defined as severe dysplasia, CIS, or cancer of…
- Trial name
- NCT00537199
- Testing
- Visual Examination, OraTest
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Neoplasms
Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates
This multicenter trial using Hologic digital mammography units will evaluate the specificity of 2-D full field digital mammography (FFDM) versus a combination of 2-D and 3-D tomosynthesis imaging in breast cancer screening.
- Trial name
- NCT01236781
- Testing
- Screening Tomosynthesis, Diagnostic Tomosynthesis
- Where
- 2 sites in United States
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Colorectal Polyp, Colorectal Adenoma
Standard Colonoscopy Versus Colonoscopy With Endocuff Vision
This study seeks to compare colonoscopy results between a standard method and one using a distal scope attachment (Endocuff Vision).
- Conditions
- Colorectal Polyp, Colorectal Adenoma, Colon Cancer
- Trial name
- NCT03361917
- Testing
- Endocuff Vision
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Lung Cancer
The INSPIRE-Lung Study
LungTalk and leveraging Facebook-targeted Advertisement (FBTA) addresses the call to develop and test multi-level, cancer communication interventions using innovative methods and designs.
- Trial name
- NCT05824273
- Testing
- LungTalk, Non-tailored intervention - Standard of practice
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Breast Cancer
Positron Emission Mammography and Standard Mammography in Women at High Risk of Breast Cancer
RATIONALE: Screening tests may help doctors find cancer cells early and plan better treatment for breast cancer. It is not yet known whether positron emission mammography is more effective than standard mammography in finding…
- Trial name
- NCT00896649
- Testing
- questionnaire administration, digital mammography, positron emission mammography
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Human Papilloma Virus (HPV)
Evaluation of the Cobas® 4800 HPV Test for the Detection of High-grade Cervical Disease
This study provided data on the performance of the Cobas® 4800 HPV Test for identifying histologically confirmed high-grade cervical disease.
- Trial name
- NCT00709891
- Testing
- cobas® 4800 HPV Test
- Where
- 61 sites in United States
- Volunteers
- 47,208 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Breast Cancer
Protocol for Women at Increased Risk of Developing Breast Cancer
To assess the effects of twelve months of celecoxib administration by evaluating breast tissue needle aspirations, to determine if cell growth can be slowed.
- Trial name
- NCT00291694
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
The investigators will study the effect of 12 months of SDG (Brevail) vs placebo on women at increased risk for development of breast cancer.
- Trial name
- NCT01276704
- Testing
- secoisolariciresinol
- Where
- 7 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Pigmented Lesions, Pigmented Skin Lesion
Pilot Study of Imaging Human Skin With High-Speed Spectrally Encoded Confocal Microscopy
The aim of this study is to evaluate the imaging performance of Spectrally Encoded Confocal Microscopy (SECM) for imaging human skin and skin diseases.
- Conditions
- Pigmented Lesions, Pigmented Skin Lesion, Pigmented Moles, Skin Lesion
- Trial name
- NCT04566302
- Testing
- SECM Skin Imaging
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dysphagia, Dysplasia
Esophageal Cytology With FISH in Detecting Esophageal Cancer
This clinical trial studies whether esophageal cytology plus fluorescence in situ hybridization (FISH) is equal to or better than esophago-gastro-duodenoscopy (EGD) or upper endoscopy for the early detection of esophageal cancer.
- Conditions
- Dysphagia, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02100189
- Testing
- Cytology Specimen Collection Procedure, Esophagogastroduodenoscopy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer
Acolbifene in Preventing Cancer in Premenopausal Women at High Risk of Breast Cancer
This phase II trial is studying how well acolbifene works in preventing cancer in premenopausal women at high risk of breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT00853996
- Testing
- acolbifene hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Glioblastomas, Sarcoma
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Background: People cope with cancer in different ways. Mindfulness means focusing on the present moment with an open mind. Researchers want to see if this can help children and young adults with a high-grade high-risk cancer with…
- Conditions
- Glioblastomas, Sarcoma, Astrocytoma, Brain Cancer
- Trial name
- NCT03538587
- Testing
- Enhanced Mindfulness Intervention, Psychoeducation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Sunburn, Erythema, Sun Protection
UV Exposure Assessed With Wearable Sensor and Sun Protection
The goal is to prevent ultraviolet light (UV) overexposure by providing consumers with relevant, easy-to-access, specifically actionable information.
- Trial name
- NCT03344796
- Testing
- Goal attainment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Colorectal Neoplasm, Colonic Polyps
Clinical Study of Real Time Colorectal Polyp Diagnosis During Colonoscopy - the VALID Colonoscopy Study
The investigators hypothesize that high definition colonoscopy with close focus narrow band imaging features has a high diagnostic accuracy for colorectal polyp histology, and can replace formal pathologic assessment in cases of…
- Trial name
- VALID (NCT01288833)
- Testing
- Close focus HD NBI Colonoscopy System
- Where
- 2 sites in United States
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
EBV-induced Lymphomas, EBV-associated Malignancies
Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV-Associated Malignancies
This is a Phase II trial to evaluate the efficacy and safety of human leukocyte antigen (HLA) partially-matched third-party allogeneic Epstein-Barr virus cytotoxic T lymphocytes (EBV-CTLs) for the treatment of EBV-induced…
- Conditions
- EBV-induced Lymphomas, EBV-associated Malignancies, Transplant Patients With EBV Viremia at High Risk for Developing a Recurrent EBV Lymphoma
- Trial name
- NCT01498484
- Testing
- EBV-specific T cells (EBV-CTLs)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Atara Biotherapeutics
Pancreatic Cancer
Secretin-Stimulated Magnetic Resonance Cholangiopancreatography (S-MRCP) in Pancreatic Patients
The aim of our study is to evaluate the utility of Secretin-Stimulated Magnetic Resonance Cholangiopancreatography (S-MRCP) in detecting carcinoma and precancerous lesions in patients with a significant family history of…
- Trial name
- NCT01094561
- Testing
- Synthetic Human Secretin, Secretin-Enhanced Magnetic Resonance Cholangiopancreatography, Secretin-Enhanced Endoscopic Ultrasound
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Elizabeth Hecht
Breast Cancer
Vitamin D in Postmenopausal Women at High Risk for Breast Cancer
This is a phase II study which will enroll 20 postmenopausal women who are at high risk for breast cancer development. The goal is to determine whether a one-year intervention of high-dose vitamin D at 2 different doses (20,000…
- Trial name
- NCT00859651
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Transplant-Related Cancer
Patient-donor Vaccination in the Context of Allogeneic Bone Marrow Transplant With Post-transplant Cyclophosphamide
This research is being done to understand the effects of certain types of bone marrow transplant (BMT) on the immune system. Your doctors are planning a BMT, using one of your family members as the bone marrow donor, for your…
- Trial name
- NCT01282216
- Testing
- Havrix, PCV13
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins