Clinical trials: High-flow Nasal Cannula Oxygen
Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
This study targets adult patients treated with high flow nasal cannula (HFNC) at emergency department (ED) of Severance hospital, Yonsei university.
- Conditions
- Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure, Hypercapnic Acute
- Trial name
- NCT06064409
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
High-flow Nasal Cannula, Oxygenation
High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs
Patients with full stomachs face a high risk of regurgitation and aspiration under general anesthesia. To minimize the time between the loss of airway protective reflexes and successful tracheal intubation, rapid sequence…
- Conditions
- High-flow Nasal Cannula, Oxygenation, General Anesthesia, Induction Anesthesia
- Trial name
- HFNC (NCT06879600)
- Testing
- High-flow nasal cannula therapy application, Traditional facemask
- Where
- Vietnam
- Volunteers
- 200 people
- Sponsor
- Nguyen Dang Thu
Acute Respiratory Failure
External Nasal Dilator and Oxygen Therapy in Respiratory Failure
Acute respiratory failure secondary to bronchiolitis and asthma is one of the most common diagnoses in children admitted to pediatric intensive care unit.
- Trial name
- HFNC (NCT02662387)
- Testing
- External nasal dilator (END), High flow nasal cannula (HFNC)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Loma Linda University
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Acute Hypoxemic Respiratory Failure
ROX Index for the Timing of Intubation in Nasal High Flow
Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality.
- Trial name
- ROX-1 (NCT04707729)
- Testing
- ROX index algorithm
- Where
- 12 sites in United States, China and 1 more
- Volunteers
- 630 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gas Exchange
High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation
Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs.
- Trial name
- NCT03441854
- Testing
- HFNC group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Need for Intubation, No Severe Hypoxemia
Benefits of High Flow Nasal Cannula Oxygen for Preoxygenation During Intubation in Non Severely Hypoxemic Patients
The aim of this study is to determine whether High Flow nasal cannula (HFNC) oxygen is more efficient than the standard High Flow face mask (HFFM) for preoxygenation before orotracheal intubation after crash induction in non…
- Trial name
- PROTRACH (NCT02700321)
- Testing
- OPTIFLOW/ AIRVO, STANDARD Face Mask
- Where
- 8 sites in France
- Volunteers
- 192 people
- Sponsor
- Nantes University Hospital
High-flow Nasal Cannula, Respiratory Distress
The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula
The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support…
- Conditions
- High-flow Nasal Cannula, Respiratory Distress, Treatment Failure
- Trial name
- NCT06146439
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Respiratory Failure, Congestive Heart Failure
Effect of High-flow Nasal Oxygen on Extubation Outcome
The purpose of this study is to determine whether high flow nasal cannula is effective in lowering the reintubation rate after extubation for high risk patients in medical intensive care unit
- Conditions
- Respiratory Failure, Congestive Heart Failure, COPD
- Trial name
- NCT02290548
- Testing
- high flow nasal cannula
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Mackay Memorial Hospital
Status Asthmaticus
High Flow Nasal Cannula in Children With Status Asthmaticus
In France, over 2.5 million people suffer from asthma, including one-third of children. This is the chronic respiratory disease leading to the highest rate of hospitalization.
- Trial name
- CANULASTHM (NCT03157102)
- Testing
- HFNC, Standard Oxygen Treatment
- Where
- 14 sites in France
- Volunteers
- 272 people
- Sponsor
- Hospices Civils de Lyon
High Flow Nasal Cannula, Obstructive Sleep Apnea
High Flow Nasal Cannula and Conventional Oxygen Therapy in the Postoperative Management of Patients With Mild to Moderate Obstructive Sleep Apnea
This study aims to compare the effectiveness of conventional oxygen therapy oxygen and high-flow nasal cannula therapy on oxygen saturation (SpO2), measuring number of SpO2 drop >4% of base line oxygen saturation (o2 desaturation…
- Trial name
- NCT06306651
- Testing
- High flow nasal cannula therapy group, Conventional oxygen therapy group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Respiratory Insufficiency, Lung Cancer
High-flow Nasal Cannula Oxygen Versus Conventional Oxygen Therapy After Pulmonary Lobectomy
The primary objective of this study is to evaluate the effect of early application of nasal high flow oxygen therapy after pulmonary lobectomy on the incidence of postoperative hypoxemia
- Trial name
- NCT02544477
- Testing
- High-flow Nasal Cannula Oxygen (HFNCO), Conventional oxygen treatment
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- Catholic University of the Sacred Heart
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Failure, Bronchoscopy
HFNC During Bronchoscopy for Bronchoalveolar Lavage
The execution of diagnostic-therapeutic investigations by bronchial endoscopy can expose the patient to acute respiratory failure (ARF). In particular, the risk of hypoxemia is greater during broncho-alveolar lavage (BAL).
- Conditions
- Acute Respiratory Failure, Bronchoscopy, Bronchoalveolar Lavage
- Trial name
- NCT04016480
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Respiratory Failure
Preoxygenation in the Intensive Care Unit Using a Nose-mouth Mask Versus High-flow Nasal Cannula Oxygen.
Preoxygenation is routinely performed before endotracheal intubation. In the intensive care unit, preoxygenation is often accomplished using a nose-mouth mask.
- Trial name
- NCT01994928
- Testing
- Nose-mouth mask, High flow nasal cannula oxygen, Intubation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Failure, Bronchiolitis
Using HFNC in Bronchiolitis
The investigators compared oxygen therapy using the HFNC and diffuser mask (an effective low-flow oxygen delivery system) to treat patients with moderate-to-severe acute bronchiolitis admitted to an intensive care unit (ICU).
- Trial name
- NCT03342781
- Testing
- high flow nasal oxygen therapy, Diffuser oxygen mask
- Volunteers
- 60 people
- Sponsor
- Kayseri Training and Research Hospital
Endometrium; Hypertrophy, Cervix, Anesthesia
High Flow Oxygen During Operative Hysteroscopy.
High-flow nasal cannula (HFNC) oxygen therapy represents an open circuit ventilation system that uses flows up to 70 L/min of 100% oxygen through the Optiflow THRIVETM device (Fisher and Paykel Healthcare Ltd, Auckland, New…
- Conditions
- Endometrium; Hypertrophy, Cervix, Anesthesia, Apnea, Postanesthetic
- Trial name
- HOPE (NCT05550584)
- Testing
- Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE)., LMA
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
Infant, Premature, Neonatal Respiratory Distress
Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants
Oxygen treatment is common in management of preterm babies requiring intensive care. Delivery of too much or too little oxygen increase the risk of damage to eyes and lungs, and contributes to death and disability.
- Conditions
- Infant, Premature, Neonatal Respiratory Distress, Oxygen Saturation, Bronchopulmonary Dysplasia
- Trial name
- MODERATION Neo (NCT05030012)
- Testing
- Automated Control, Manual Control
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vapotherm, Inc.