Clinical trials: High-flow Nasal Oxygen Therapy
Hypoxemic Acute Respiratory Failure
High Flow Nasal Oxygen Therapy for Hypoxemy After Cardiac Surgery
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
- Trial name
- Optiflow (NCT01617252)
- Testing
- Optiflow / Facial mask
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Respiratory Distress Syndrome, Ventilation Therapy; Complications
Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
The investigators aimed to investigate the ventilation homogeneity and transpulmonary pressure during treatments of High-flow nasal cannula(HFNC) and (CPAP) on supine and prone position for COVID-19 or non-COVID-19 patients with…
- Trial name
- NCT05719103
- Testing
- With and Without Awake Prone Positioning
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Zhongshan Hospital
Pulmonary Atelectasis, Patient Comfort
HFNC During Awake Craniotomy - Impact on Patient Comfort
Background: Patients undergoing awake brain surgery are exposed to non-humidified, non-warmed oxygen/air mix flow through a face mask for a prolonged duration.
- Trial name
- NCT03763461
- Testing
- HFNC, Oxygen Mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
Hypoxemia, Gastrointestinal Endoscopy
THRIVE in Sedated Gastrointestinal Endoscopy
This prospective observational study aims to evaluate the effectiveness of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) compared to standard nasal cannula (SNC) oxygen supplementation in patients…
- Trial name
- NCT07487051
- Testing
- High-Flow Nasal Oxygen (THRIVE), Standard Nasal Cannula Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 222 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Gastric Distention
High-Flow Heated and Humidified Oxygen Therapy and Gastric Distension
High Flow Heated and Humidified Nasal Oxygen therapy (HFHHNO) has been increasingly used in emergency medicine to assist patients with short term respiratory failure and to provide adequate oxygen to the body prior to intubation.
- Trial name
- HFHHNOGastric (NCT03134937)
- Testing
- High-Flow Heated and Humidified Oxygen Therapy (HFHHNO)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Critically Illness
The Efficiency of HHHFNC Between Unheated Oxygen Therapy in Difficult Weaning Patients After Extubation in RCC
The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged…
- Trial name
- HHHFNC (NCT04564859)
- Testing
- Heated Humidified High-Flow Nasal Cannula
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Covid19, Acute Hypoxemic Respiratory Failure
High-Flow Nasal Cannula in Severe COVID-19 With Acute Hypoxemic Respiratory Failure.
This open label randomized controlled multicenter phase II trial will evaluate the clinical impact of the use of HFNC vs. conventional oxygen therapy in patients with moderate and severe hypoxemic acute respiratory failure…
- Trial name
- HiFlo-COVID (NCT04609462)
- Testing
- Conventional oxygen therapy, High flow nasal cannula
- Where
- Colombia
- Volunteers
- 199 people
- Sponsor
- Fundacion Clinica Valle del Lili
Lung Cancer, Lymphadenopathy
Assessment of High Flow Nasal Cannula Oxygenation in EBUS Bronchoscopy
This study is a prospective randomised trial where a computer will randomly allocate patients to one of two possible methods of delivering oxygen during the procedure of bronchoscopy.
- Trial name
- AHOE (NCT03226964)
- Testing
- high flow nasal oxygen
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
Need for Intubation, No Severe Hypoxemia
Benefits of High Flow Nasal Cannula Oxygen for Preoxygenation During Intubation in Non Severely Hypoxemic Patients
The aim of this study is to determine whether High Flow nasal cannula (HFNC) oxygen is more efficient than the standard High Flow face mask (HFFM) for preoxygenation before orotracheal intubation after crash induction in non…
- Trial name
- PROTRACH (NCT02700321)
- Testing
- OPTIFLOW/ AIRVO, STANDARD Face Mask
- Where
- 8 sites in France
- Volunteers
- 192 people
- Sponsor
- Nantes University Hospital
Pediatric Sedation
Evaluation of the Efficacy of Oxygen Therapy and Clinical Feasibility of High Flow Nasal Cannula During Moderate and Deep Sedation in Pediatric Patients
The investigators evaluate the efficacy and safety of routine administration of oxygen during moderate or deep sedation in pediatric patients.
- Trial name
- NCT04852432
- Testing
- high flow nasal cannula, nasal prong
- Where
- South Korea
- Volunteers
- 258 people
- Sponsor
- Seoul National University Hospital
Postoperative Pulmonary Complications (PPCs)
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery.
- Trial name
- Hi-POP (NCT07464730)
- Testing
- High Flow Oxygen, Oxygen
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Acute Respiratory Failure
High Flow Nasal Cannulas in Children
Non-invasive Continuous Positive Airway Pressure (nCPAP) is widely recognized as an efficient respiratory support in infants with mild to moderate Acute Hypoxemic Respiratory Failure (AHRF).
- Trial name
- HFNC (NCT03689686)
- Testing
- Noninvasive Respiratory Support
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypoxemia
The Correlation Between Sleep Quality and Atrial Fibrillation Undergoing High-flow Nasal Cannula Oxygen (HFNC)
The investigators hypothesized that heated humidified high-flow nasal cannula oxygen(HFNC) along with high quality of sleep, in comparison with noninvasive positive pressure ventilation (NIV), could reduce the release of…
- Trial name
- NCT02713737
- Testing
- heated humidified high-flow nasal cannula, noninvasive ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
De Novo Hypoxemic Acute Respiratory Failure (hARF)
Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate.
- Trial name
- HighCPAP (NCT06213168)
- Testing
- HFNC, CPAP and HFNC
- Where
- 29 sites in France
- Volunteers
- 1,084 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Care, High-flow Nasal Cannula Oxygen
Effect of High-flow Nasal Cannula Oxygen on Lung Volumes Determined by Electrical Impedance Tomography
Effect of High-flow nasal cannula oxygen on end-expiratory lung volumes determined by electrical impedance tomography
- Conditions
- Critical Care, High-flow Nasal Cannula Oxygen, Electrical Impedance Tomography, End Expiratory Lung Volume
- Trial name
- OXIDIA (NCT02186288)
- Testing
- High-flow nasal cannula oxygen
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cardiovascular Diseases
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
Optiflow (high flow humified nasal oxygen) is used in several settings frequently (ICU, during elective general anaesthesia- commonly here on the TOE list, in certain ENT patients, and more commonly now in obese or obstetric…
- Trial name
- NCT03619148
- Testing
- High-Flow Humidified Nasal Oxygen
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Torbay and South Devon NHS Foundation Trust
High-risk for Reintubation Patients, Weaning Outcome
Inspiratory Muscle Training and Nasal High Flow in Difficult Weaning
The purpose of the present study is to investigate the effectiveness of inspiratory muscle training and nasal high flow oxygen in patients with difficult weaning and high-risk for re-intubation.
- Trial name
- NCT03908658
- Testing
- Inspiratory muscle Training and Nasal High Flow, Inspiratory muscle training and Venturi mask
- Where
- Greece
- Volunteers
- 146 people
- Sponsor
- Evangelismos Hospital
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Covid19, Acute Respiratory Failure
HFNT vs. COT in COVID-19
The aim of this unblinded parallel-group randomized multicenter clinical trial is to compare the clinical effectiveness of high flow nasal therapy (HFNT) with conventional oxygen therapy (COT) in patients with confirmed COVID-19…
- Trial name
- COVID-HIGH (NCT04655638)
- Testing
- High Flow Nasal Therapy, Conventional Oxygen Therapy
- Where
- 27 sites in Greece, Italy and 4 more
- Volunteers
- 364 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Acute Respiratory Failure With Hypercapnia
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasive ventilation.
- Trial name
- NCT03229460
- Testing
- standard low flow therapy, high flow nasal oxygen therapy, association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine