Clinical trials: High-flow Nasal Oxygen Therapy
Laryngologic Surgical Procedures
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Short Laryngologic Surgery
The purpose of this study is to investigate whether selected, short laryngologic surgical procedures can be safely and potentially more effectively performed without the use of endotracheal tube or jet ventilation, under…
- Trial name
- NCT03091179
- Testing
- THRIVE, Endotracheal tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Hypoxemia
POM vs HFNC for Hypoxemia Prevention in Children
Upper gastrointestinal endoscopy is a commonly performed diagnostic and therapeutic procedure in children, allowing evaluation of the esophagus, stomach, and duodenum, as well as interventions such as biopsy, foreign body…
- Trial name
- NCT07234188
- Testing
- Procedural Oxygen Mask, High-Flow Nasal Cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bedirhan Günel
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
COVID-19, Acute Respiratory Failure
High Frequency Percussive Ventilation in COVID-19 Patients
High frequency percussive ventilation (HFPV) is used in patients with underlying pulmonary atelectasis, excessive airway secretions, and respiratory failure.
- Trial name
- NCT05358184
- Testing
- High frequency Percussive ventilation
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Hypoxia, Oxygen Therapy
Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia
High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently introduced for bedside care. It has been shown to be associated with reduced risks of tracheal intubation rates and mortality in adult hypoxic…
- Conditions
- Hypoxia, Oxygen Therapy, High Flow Nasal Cannula, Ventilation
- Trial name
- NCT02943863
- Testing
- HFNC followed by conventional nasal cannula, Conventional nasal cannula followed by HFNC
- Volunteers
- 24 people
- Sponsor
- Asan Medical Center
Upper Gastrointestinal Bleeding
HFNC Versus Conventional Oxygen Therapy in Prolonged Upper Gastrointestinal Endoscopy in the ICU
Conventional supplemental oxygen therapy (COT) during upper gastrointestinal (UGI) endoscopy via nasal catheter is considered the standard practice in maintenance of oxygenation and prevention of hypoxia.
- Trial name
- NCT06350864
- Testing
- High-flow nasal cannula (HFNC), Conventional nasal oxygen therapy (COT), Upper gastrointestinal endoscopy (UGE) including gastroscopy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Obese
The Effect of Mask Combined With High Flow Oxygen on Preoxygenation During Induction of General Anesthesia in Obese Patients
There is a risk of airway-related incidents during anaesthesia associated with obesity. High-flow nasal oxygen is advocated for perioperative preoxygenation in obese patients to reduce airway adverse reactions.
- Trial name
- NCT06562660
- Testing
- apnoeic
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Lung Diseases, Obstructive
Prospective Randomized Study of Nasal High Flow in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The main oxygen therapy to the patients with acute exacerbation of Chronic obstructive pulmonary disease, who are mild to moderate respiratory insufficiency (arterial blood gas analysis showed pH = 7.35, PO2 <…
- Trial name
- NCT02439333
- Testing
- Nasal high flow cannula (Fisher & Paykel Healthcare, Auckland, New Zealand), nasal catheter or Venturi mask
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Li Xuyan
Oxygen Delivery, Acute Respiratory Failure
Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target.
- Conditions
- Oxygen Delivery, Acute Respiratory Failure, High Flow Oxygen Therapy, Hypoxemic Acute Respiratory Failure
- Trial name
- NCT07168213
- Testing
- Manual FiO2 titration with Philips oximeter (SpO2 target 90%), Manual FiO2 titration with Nonin oximeter (SpO2 target 90%), Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Patients Undergoing Endoscopic Retrograde Cholangiopancreatography in Prone Position
A Trial Comparing High-flow Nasal Oxygen With Standard Management for Conscious Sedation During Endoscopic Retrograde Cholangiopancreatography in Prone Position
Traditional conscious sedation for endoscopic retrograde cholangiopancreatography in prone position places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk.
- Trial name
- NCT03872674
- Testing
- high-flow humidified oxygen-delivery system (OptiFlow THRIVE)
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Oxygen Deficiency
Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units Patients
Patients with one or more organ failure (heart, lung) require hospitalization in intensive care where these failures can be managed.
- Trial name
- OHE-REA (NCT04141956)
- Testing
- High-Flow Nasal Cannula
- Where
- 10 sites in France
- Volunteers
- 257 people
- Sponsor
- Nantes University Hospital
Interstitial Lung Disease (ILD)
Nasal High-flow Oxygen Therapy During Rehabilitive Exercise Training in ILD
Although uncommon, interstitial lung diseases (ILDs), and particularly idiopathic pulmonary fibrosis (IPF), are progressive, irreversible, and ultimately fatal without treatment.
- Trial name
- PID-OX (NCT07679854)
- Testing
- Pulmonary rehabilitation with NHFO2, Pulmonary rehabiltation with conventional oxygen therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Frédéric Hérengt
Respiratory Failure With Hypoxia
Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan
evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.
- Trial name
- NCT04657796
- Testing
- High Flow Nasal Cannula
- Volunteers
- 84 people
- Sponsor
- Assiut University
Bronchiolitis
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
Over the last decade, high-flow nasal oxygen therapy (HFN) has emerged as a new method to provide respiratory support in children with moderate to severe bronchiolitis.
- Trial name
- BRONCHOPTI (NCT02856165)
- Testing
- High-flow nasal canula oxygen therapy, Low-flow oxygen therapy with standard nasal canula
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Flow Nasal Canula, Laryngoscopy
Effect of High-Flow Nasal Oxygen on Laryngoscopic View
This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing…
- Conditions
- High Flow Nasal Canula, Laryngoscopy, Airway Anesthesia, Airway Complication of Anaesthesia
- Trial name
- NCT07575776
- Testing
- HFNO flow 0, HFNO flow 40, HFNO 60
- Volunteers
- 150 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Respiratory Insufficiency, Hypoxia
Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation
1. To determine the lowest nasal cannula flow rate in which upper airway deadspace is reduced. Hypothesis - The lowest flow rate of high flow nasal cannula (HFNC) will reduce upper airway (extrathoracic) deadspace and improve…
- Trial name
- HFNC (NCT02460653)
- Testing
- HFNC Flow Rate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Post-Acute COVID-19, Post-Acute COVID-19 Infection
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection.
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Infection, Post-Acute COVID-19 Syndrome, Pulmonary Fibrosis
- Trial name
- FAPI CLIMATE (NCT05981885)
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
COPD
High Flow Nasal Cannula on Exercise Endurance in COPD
Ventilation limitation has a significant adverse effects on cardiovascular function and cerebral oxygenation during exercise in patients with COPD.
- Trial name
- NCT03883256
- Testing
- high flow nasal cannula, nasal cannula
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Chang Gung University
Severe Obesity Design as BMI > 35kg/m2
Preoxygenation Optimisation in Obese Patients
Oro-tracheal intubation in operating room in obese patients with BMI > 35kg/m2 remains a critical event. The aim of this study is to determine whether Nasal High Flow Therapy by nasal cannula Optiflow® is more efficient than the…
- Trial name
- PREOPTI-POOP (NCT03106441)
- Testing
- High flow oxygen therapy by nasal cannula. Optiflow®, Facial mask oxygenation in BIPAP ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital