Clinical trials: High-flow Nasal Oxygen Therapy
Obese
The Effect of Mask Combined With High Flow Oxygen on Preoxygenation During Induction of General Anesthesia in Obese Patients
There is a risk of airway-related incidents during anaesthesia associated with obesity. High-flow nasal oxygen is advocated for perioperative preoxygenation in obese patients to reduce airway adverse reactions.
- Trial name
- NCT06562660
- Testing
- apnoeic
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Obesity
Effect of Different-Flow High-Flow Nasal Cannula Versus Traditional Face Mask Oxygenation on Safe Apnea Time in Obese Patients
Obesity is a growing global health problem, and patients with obesity are at higher risk of hypoxemia during induction of general anesthesia.
- Trial name
- NCT07843810
- Testing
- Face Mask, High-Flow Nasal Cannula
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The First People's Hospital of Lianyungang
Respiratory Syndrome, Acute, Severe, Hypoxic Respiratory Failure
Use of High Flow Nasal Cannula Oxygen and Covid-19 Acute Hypoxemic Respiratory Failure
Nasal High Flow oxygen therapy (NHF) is commonly used as first line ventilatory support in patients with acute hypoxemic respiratory failure (AHRF). It's use has been initially limited in Covid-19 patients presenting with AHRF.
- Conditions
- Respiratory Syndrome, Acute, Severe, Hypoxic Respiratory Failure, Viral Pneumonia
- Trial name
- NCT04385823
- Testing
- patients receiving nasal high flow
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hôpital Louis Mourier
High-risk for Reintubation Patients, Weaning Outcome
Inspiratory Muscle Training and Nasal High Flow in Difficult Weaning
The purpose of the present study is to investigate the effectiveness of inspiratory muscle training and nasal high flow oxygen in patients with difficult weaning and high-risk for re-intubation.
- Trial name
- NCT03908658
- Testing
- Inspiratory muscle Training and Nasal High Flow, Inspiratory muscle training and Venturi mask
- Where
- Greece
- Volunteers
- 146 people
- Sponsor
- Evangelismos Hospital
Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation.
- Trial name
- NCT04640948
- Testing
- High flow nasal therapy, Low flow oxygen
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Belfast Health and Social Care Trust
Obstructive Sleep Apnea
Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients
The study aims to compare the efficacy of Nasal High Flow Therapy (NHF) with low-flow oxygen supplementation in improving postoperative intermittent desaturations.
- Trial name
- NCT02485236
- Testing
- Low flow oxygen via nasal cannula, Humidified Nasal High Flow Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Acute Respiratory Failure
Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF
The goal of this clinical trial is to determine whether one of the two oxygenation or ventilation strategies (NIV and/or HFNO) is superior to standard oxygen to reduce 28-day mortality rate in hypoxemic acute respiratory failure…
- Trial name
- KISS (NCT05812911)
- Testing
- Standard oxygen, HFNO, NIV
- Where
- France
- Volunteers
- 1,470 people
- Sponsor
- University Hospital, Montpellier
Lung Collapse
HFNC for Induction During Bariatric Surgery Patients.
This study aims to compared the effects of high flow nasal during the induction and during the weaning of anesthesia on intraoperative and postoperative oxygenation and postoperative atelectasis in obese patients undergoing…
- Trial name
- NCT03155711
- Testing
- HFNC group, Standard group
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Laryngeal Disease
Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery
During apnoeic oxygenation there is a continuous raise in carbon dioxide with subsequent respiratory acidosis. The hypercapnia and respiratory acidosis have several dose-related effects on both the systemic and the pulmonary…
- Trial name
- CAPOX (NCT06316063)
- Testing
- Apnoeic oxygenation with high-flow nasal oxygen, Mechanical ventilation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Stockholm
Hypercapnia, Asthma Exacerbation
Combination of High-flow Nasal Oxygen (Optiflow) and Vibrating Membrane Nebuliser (Aerogen) in the Pre-hospital Setting - Before/After Study
The aim of this observational before/after study is to determine how to optimally administer oxygen to patients experiencing an asthma or COPD exacerbation in emergency medical services.
- Conditions
- Hypercapnia, Asthma Exacerbation, COPD Exacerbation
- Trial name
- O2NAB (NCT07791992)
- Testing
- Vibrating membrane nebulizer and high-intensity nasal oxygen, nebulizer mask and oxygen therapy of 6 to 9 liters per minute
- Where
- France
- Sponsor
- Centre Hospitalier Sud Francilien
Rapid Sequence Induction (RSI), Preoxygenation
High Flow Oxygen in Preoxygenation During Rapid Sequence Induction in Infants and Small Children
Airway management is crucial part of the anaesthesia. There is always a considerable risk of complications or even failure during the anaesthesia induction and airway management.
- Trial name
- PRSIHFO (NCT05846919)
- Testing
- face-mask preoxygenation, HFNOC preoxygenation, HFNOC + face-mask preoxygenation
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Apnea, Respiration; Arrest
Pre-oxygenation With Facemask Oxygen vs High-flow Nasal Oxygen vs High-flow Nasal Oxygen Plus Mouthpiece Oxygen
Pre-oxygenation increases oxygen reserves in the body to reduce the likelihood of oxygen desaturation on induction of general anaesthesia. Pre-oxygenation with facemask is the commonest method method of pre-oxygenation.
- Conditions
- Apnea, Respiration; Arrest, Anesthesia
- Trial name
- PREOX (NCT04767867)
- Testing
- Pre-oxygenation
- Where
- Ireland
- Volunteers
- 84 people
- Sponsor
- University College Hospital Galway
Cardiac Valve Disease, Coronary Artery Disease
Nasal Oxygen Therapy After Cardiac Surgery
NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation, inclusive of up to one hour off randomised therapy for transfers around the hospital and/or physio…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Respiratory Failure
- Trial name
- NOTACS (NCT05308719)
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 1,280 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Electroconvulsive Therapy Treated Patients, Obesity
LMA vs High-flow Nasal Oxygen During ECT in Obese Patients
This study aims to compare two oxygenation strategies-laryngeal mask airway (LMA) ventilation and high-flow nasal cannula (HFNC)-during electroconvulsive therapy (ECT) in obese patients.
- Trial name
- NCT07093372
- Testing
- Laryngeal Mask Airway, High-Flow Nasal Cannula
- Volunteers
- 25 people
- Sponsor
- Eulji University Hospital
Pulmonary Rehabilitation
Improving Outcomes of Respiratory Patients With Exertional Hypoxemia
The primary aim of this pilot randomized controlled trial is to determine feasibility of the proposed pulmonary rehabilitation intervention.
- Trial name
- NCT05752370
- Testing
- High flow oxygen, Usual care
- Where
- Singapore
- Volunteers
- 56 people
- Sponsor
- Changi General Hospital
Central Sleep Apnea, Cheyne-Stokes Respiration
Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT)
To investigate whether nHFT is an effective treatment for patients with Chronic Heart Failure (CHF) and central sleep apnea (CSA).
- Trial name
- RELAX (NCT03085641)
- Testing
- Nasal high flow oxygen therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Intubation Intraesophageal
Non Invasive Ventilation Combined to High Flow Nasal Cannula Oxygen for Preoxygenation of Hypoxemic ICU Patients
Tracheal intubation is a challenging procedure in Intensive Care Unit (ICU), associated with severe life threatening complications. To decrease these complications, preoxygenation is recommended.
- Trial name
- OPTINIV (NCT02530957)
- Testing
- Non invasive ventilation + High flow nasal cannula oxygen, Non invasive ventilation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Deep Sedation, Oxygen Therapy
HFNC Vs LFNC in Patients with AF Undergoing RFCA Under Deep Sedation.
Oxygen supplementation through high flow nasal cannula (HFNC) may reduce the incidence of desaturation and hypoxemia during deep sedation at radiofrequency catheter ablation (RFCA procedures).This study is designed to test the…
- Conditions
- Deep Sedation, Oxygen Therapy, Radiofrequency Ablation
- Trial name
- NCT04842253
- Testing
- High flow nasal cannula
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- Maastricht University Medical Center
Covid19, Acute Hypoxemic Respiratory Failure
High-Flow Nasal Cannula in Severe COVID-19 With Acute Hypoxemic Respiratory Failure.
This open label randomized controlled multicenter phase II trial will evaluate the clinical impact of the use of HFNC vs. conventional oxygen therapy in patients with moderate and severe hypoxemic acute respiratory failure…
- Trial name
- HiFlo-COVID (NCT04609462)
- Testing
- Conventional oxygen therapy, High flow nasal cannula
- Where
- Colombia
- Volunteers
- 199 people
- Sponsor
- Fundacion Clinica Valle del Lili
Patients Undergoing Endoscopic Submucosal Dissection
A Comparison of High-flow Nasal Oxygen and Conventional Nasal Cannula in Monitored Anesthesia Care for Endoscopic Submucosal Dissection
Sedation for endoscopic submucosal dissection places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk.
- Trial name
- NCT06688019
- Testing
- conventional oxygenation (nasal cannula), high-flow humidified oxygen-delivery system (OptiFlow THRIVE)
- Volunteers
- 200 people
- Sponsor
- Yonsei University