Clinical trials: High-flow Nasal Oxygen Therapy
Dyspnea
High-flow Nasal Oxygen in Palliative Care: Pilot Study
In palliative care, the relief of the dyspnea is necessary. Medications for the reduction of dyspnea have side effects. High-flow nasal cannula oxygen therapy (HFNC) is a new way to deliver oxygen.
- Trial name
- OXYPALL (NCT03423888)
- Testing
- high-flow nasal cannula oxygen therapy (HNFC)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Chronic Obstructive Lung Disease, Respiratory Insufficiency
The Edi Level and Cardiopulmonary Function Between HHHFNC and Unheated Humidified High-Flow Oxygen Mask in COPD
Patients with COPD exacerbation usually need respiratory support after extubation. Recently, HHHFNC has been used in both adult and neonates with post-extubation respiratory support.
- Trial name
- NCT03811158
- Testing
- HHHFNC, UHFOM
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- Fu Jen Catholic University
Obese
HFNO Versus Nasal CPAP in Obese Patients Undergoing Deep Sedation for ERCP
Endoscopic retrograde cholangio-pancreatography (ERCP) is commonly performed under deep sedation to provide amnesia, comfort, and optimal procedural conditions.
- Trial name
- NCT04912102
- Testing
- high flow nasal oxygen device (HFNO)
- Volunteers
- 270 people
- Sponsor
- Assiut University
Laryngeal Disease
Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery
During apnoeic oxygenation there is a continuous raise in carbon dioxide with subsequent respiratory acidosis. The hypercapnia and respiratory acidosis have several dose-related effects on both the systemic and the pulmonary…
- Trial name
- CAPOX (NCT06316063)
- Testing
- Apnoeic oxygenation with high-flow nasal oxygen, Mechanical ventilation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Stockholm
Hypoxia
Efficacy of High-flow Nasal Oxygen in Preventing Hypoxia During Gastrointestinal Endoscopy: a Retrospective Cohort Study
During painless gastroscopy, the occurrence of hypoxia is a critical concern, especially under intravenous anesthesia using propofol.
- Trial name
- NCT06710613
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Fengli Liu
Severe Obesity Design as BMI > 35kg/m2
Preoxygenation Optimisation in Obese Patients
Oro-tracheal intubation in operating room in obese patients with BMI > 35kg/m2 remains a critical event. The aim of this study is to determine whether Nasal High Flow Therapy by nasal cannula Optiflow® is more efficient than the…
- Trial name
- PREOPTI-POOP (NCT03106441)
- Testing
- High flow oxygen therapy by nasal cannula. Optiflow®, Facial mask oxygenation in BIPAP ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Bronchiolitis
High Flow Nasal Cannula Use in Infants With Bronchiolitis
Infants with viral bronchiolitis are currently treated with oxygen therapy if oxygen saturation is low. In earlier observational clinical studies, the use of high flow nasal cannulae therapy in infants with bronchiolitis has been…
- Trial name
- NCT02737280
- Testing
- Airvo (TM, Fisher & Paykel Healthcare) - High flow oxygen therapy, MedKit Finland - Usual oxygen therapy
- Where
- 4 sites in Finland
- Volunteers
- 18 people
- Sponsor
- University of Oulu
Hypercapnic Respiratory Failure, Acute Copd Exacerbation
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
Current evidence suggests a mechanistic and physiological rationale for the use of high flow nasal cannula (HFNC) in acute respiratory hypoxemic failure (AHRF) based on physiological studies in airway models, healthy volunteers…
- Trial name
- NCT05497986
- Testing
- High flow nasal cannula, Conventional low flow oxygenation
- Where
- 3 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Hôpital de Verdun
Respiratory Failure With Hypoxia
Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan
evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.
- Trial name
- NCT04657796
- Testing
- High Flow Nasal Cannula
- Volunteers
- 84 people
- Sponsor
- Assiut University
ENT Tumor
Comparison of HFNO and FMV on Desaturations During Panendoscopy Under General Anesthesia
Panendoscopy is a common procedure that requires deep and short anesthesia. The main challenge is the sharing of the airway between the anesthesia team and the surgical team.
- Trial name
- NCT05593718
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pneumonia, Respiratory Failure
CPAP Versus HFNO for the Treatment of Acute Hypoxemic Respiratory Failure Due to Community Acquired Pneumonia
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
- Trial name
- NCT05755425
- Testing
- CPAP, HFNO
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Evangelismos Hospital
Oxygen, Respiratory Insufficiency
INSPIRatory Efforts Estimation Under High-flow Nasal Oxygen
High-flow nasal oxygen (HFNO) is recommended as first-line treatment to prevent intubation in acute hypoxemic respiratory failure and to prevent reintubation after extubation.
- Conditions
- Oxygen, Respiratory Insufficiency, Work of Breathing, Dyspnea
- Trial name
- INSPIRE-Pilot (NCT07228676)
- Testing
- Non-invasive estimation of inspiratory effort
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Bronchiolitis
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
Over the last decade, high-flow nasal oxygen therapy (HFN) has emerged as a new method to provide respiratory support in children with moderate to severe bronchiolitis.
- Trial name
- BRONCHOPTI (NCT02856165)
- Testing
- High-flow nasal canula oxygen therapy, Low-flow oxygen therapy with standard nasal canula
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease (COPD)
Study of Long-term HFNC for COPD Patients with HOT
This is a prospective, randomized parallel study for evaluation of the efficacy and safety of long-term nocturnal high-flow nasal cannula therapy (HFNC: with the myAIRVO2 as HFNC in this study) in stable COPD patients with the…
- Trial name
- FLOCOP (NCT03282019)
- Testing
- High-flow nasal cannula therapy, Home oxygen therapy (HOT)
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Respiratory Failure
Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will…
- Trial name
- NCT07521254
- Testing
- HFNC, NIV
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Minia University
Acute Respiratory Failure
A Randomised Controlled Trial of High-Flow Nasal Oxygen Versus Standard Oxygen Therapy in Critically Ill Immunocompromised Patients
Acute respiratory failure (ARF) is the leading reason for ICU admission in immunocompromised patients. Usual oxygen therapy involves administering low-to-medium oxygen flows through a nasal cannula or mask [with or without a bag…
- Trial name
- HIGH (NCT02739451)
- Testing
- standard oxygen, HFNO
- Where
- France
- Volunteers
- 776 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Cardiogenic Pulmonary Edema, Hypercapnic Respiratory Failure
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
The purpose of this study is to determine whether high flow nasal oxygen (HFNO) therapy is non inferior to non invasive ventilation (NIV) in the immediate treatment of patients with acute hypercapnic cardiogenic pulmonary edema…
- Trial name
- OPTICAP (NCT02874339)
- Testing
- High flow nasal oxygen therapy, Non invasive ventilation
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Interstitial Lung Disease, Pulmonary Rehabilitation
Physiological Effects of HFNC During Exercise in Patients With Fibrosing Interstitial Lung Diseases
in this study, the investigators aim to describe the effects of highflow nasal canulae oxygen therapy (HFNC) on respiratory muscle function during exercise in patients with fibrosing interstitial lung diseases (ILD) during an…
- Trial name
- HighFlowMusc (NCT05372926)
- Testing
- high flow nasal canulae, Ventury mask
- Where
- France
- Volunteers
- 16 people
- Sponsor
- ADIR Association
High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure
HFNC and Acute Hypercapnic Respiratory Failure
High-flow nasal cannula (HFNC) enables delivering humidified gas at high-flow rates controlling the oxygen inspired fraction (FiO2). Its efficacy has been demonstrated in hypoxemic acute respiratory failure.
- Conditions
- High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure, COPD Exacerbation
- Trial name
- NCT04109560
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Argentinian Intensive Care Society