Clinical trials: High-flow Nasal Oxygen Therapy
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
Airway Anesthesia, Preoxygenation
Comparison of Different Oxygen Flow Rates During Preoxygenation Using High-Flow Nasal Oxygen
High-flow nasal oxygen (HFNO) has been used for many years to help people with breathing difficulties in the intensive care and after surgery.
- Conditions
- Airway Anesthesia, Preoxygenation, High Flow Nasal Canula
- Trial name
- PREFLOW2 (NCT06736132)
- Testing
- High-flow nasal oxygen
- Where
- Sweden
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Acute Respiratory Failure, High Flow Nasal Cannula
Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
- Conditions
- Acute Respiratory Failure, High Flow Nasal Cannula, Critically Ill, Airway Disease
- Trial name
- HPEEP (NCT05467332)
- Testing
- HIGH FLOW NASAL OXYGEN
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Hypoxemia, Airway Management
Comparison of High-Flow Nasal Cannula and Tight Face Mask for Maintaining Oxygenation During Rapid Sequence Induction
This prospective randomized controlled trial aims to compare the effectiveness of High-Flow Nasal Cannula (HFNC) versus Tight Face Mask (TFM) in maintaining oxygenation during rapid sequence induction (RSI) for endotracheal…
- Conditions
- Hypoxemia, Airway Management, Endotracheal Intubation, Rapid Sequence Induction
- Trial name
- NCT07723430
- Testing
- High-Flow Nasal Cannula, Tight Face Mask
- Volunteers
- 290 people
- Sponsor
- Khyber Teaching Hospital
Postoperative Pulmonary Complications (PPCs)
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery.
- Trial name
- Hi-POP (NCT07464730)
- Testing
- High Flow Oxygen, Oxygen
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Lower Limb Ischaemia
Nasal High Flow Oxygen in Patients With Lower-Limb Ischaemia
A prospective, single arm pilot efficacy study designed to evaluate the physiological and symptomatic effects of normobaric Nasal High Flow (NHF) oxygen therapy in patients with lower limb ischaemia experiencing rest pain and/or…
- Trial name
- NCT07891208
- Testing
- Nasal high flow oxygen
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
Acute Respiratory Distress Syndrome, COVID-19
Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)
Acute Respiratory Distress Syndrome (ARDS) induces high mortality, particularly in the context of COVID-19 disease. Preliminary data from patients with ARDS related to COVID-19 disease appear to show significant effectiveness of…
- Trial name
- NCT04358939
- Testing
- Prone decubitus
- Where
- 24 sites in France
- Volunteers
- 405 people
- Sponsor
- University Hospital, Tours
Weaning Failure, Acute Respiratory Failure
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
- Trial name
- RINO (NCT02107183)
- Testing
- Optiflow (Fisher & Paykel Healthcare), Venturi mask
- Where
- 14 sites in France, Greece and 2 more
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Obstructive Sleep Apnea
Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants
This is a small pilot study that will compare High Flow Nasal Cannula (HFNC) therapy to oxygen nasal cannula therapy on infants who have obstructive sleep apnea (OSA) and are scheduled for a clinically ordered sleep study called…
- Trial name
- NCT02858154
- Testing
- HFNC, Low flow oxygen by nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypoxia
Comparison of Hypoxia Between HFNC and SNC in Patient Undergoing UGI Endoscopic Procedures in Deep Sedation
Hypoxia frequently occurs as a complication during upper gastrointestinal endoscopic procedures performed under deep sedation. Traditional oxygen delivery methods, such as the simple nasal cannula, are commonly used to prevent…
- Trial name
- NCT06482879
- Testing
- Oxygen delivery
- Where
- Nepal
- Volunteers
- 122 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Healthy
Comparison of Preoxygenation Techniques in Healthy Volunteers With Monitoring of End-tidal Oxygen Fraction (FeO₂) and Oxygen Reserve Index (ORI)
The objective of this physiological study is to compare two preoxygenation techniques (non-invasive ventilation combined with high-flow nasal oxygen versus non-invasive ventilation alone) by monitoring end-tidal oxygen fraction…
- Trial name
- OXYGAME1 (NCT07334041)
- Testing
- Preoxygenation with VNI + OHD, Preoxygenation with VNI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Respiratory Distress Syndrome, Ventilation Therapy; Complications
Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
The investigators aimed to investigate the ventilation homogeneity and transpulmonary pressure during treatments of High-flow nasal cannula(HFNC) and (CPAP) on supine and prone position for COVID-19 or non-COVID-19 patients with…
- Trial name
- NCT05719103
- Testing
- With and Without Awake Prone Positioning
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Zhongshan Hospital
Bronchoscopy,Oxygen
Modified HFNC Oxygen in Patients Undergoing Bronchoscopy.
The purpose of this study is to determine whether the Modified High-flow nasal cannula is effective in the oxygen of the patients undergoing bronchoscopy.
- Trial name
- NCT02606188
- Testing
- Modified High-flow nasal cannula, nasal cannula
- Where
- China
- Volunteers
- 812 people, healthy volunteers welcome
- Sponsor
- Haichao Li
Blunt Thoracic Injury, Lung Ultrasound Score
High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients
This prospective randomized controlled study was conducted in the emergency intensive care units (EICU) of the second affiliated hospital Zhejiang university school of medicine, a large tertiary university hospital in HangZhou…
- Trial name
- NCT03430258
- Testing
- high-flow nasal cannula, Conventional oxygen therapy
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Exacerbation of COPD
High Flow Nasal Oxygen for Exacerbation COPD
In this pilot study the feasibility of performing a larger trial to study the non-inferiority of High Flow Nasal Oxygen compared to non-invasive ventilation in patients with acute acidotic hypercapnic exacerbation of COPD wil be…
- Trial name
- HiCAP (NCT06084117)
- Testing
- HFNO, NIV
- Where
- 4 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Franciscus Gasthuis
High-risk for Reintubation Patients, Weaning Outcome
Inspiratory Muscle Training and Nasal High Flow in Difficult Weaning
The purpose of the present study is to investigate the effectiveness of inspiratory muscle training and nasal high flow oxygen in patients with difficult weaning and high-risk for re-intubation.
- Trial name
- NCT03908658
- Testing
- Inspiratory muscle Training and Nasal High Flow, Inspiratory muscle training and Venturi mask
- Where
- Greece
- Volunteers
- 146 people
- Sponsor
- Evangelismos Hospital
Bronchoscopy
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
The purpose of study aims to determine which of the three different oxygenation strategies, including nasal cannula, modified nasopharyngeal cannula, and HFNO groups, is safer in patients undergoing bronchoscopy under sedation.
- Trial name
- NCT05912985
- Testing
- different oxygenation methods
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Ankara City Hospital Bilkent
Hypercapnic Respiratory Failure
High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure
this study evaluates high flow oxygen therapy in addition to non invasive ventilation (NIV) to treat hypercapnic respiratory failure.
- Trial name
- NCT03627598
- Testing
- HFNC, standard
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Mahdia
Foreign Bodies, Tumor
High-flow Nasal Oxygen During Rigid Bronchoscopy Under General Anesthesia: a Randomized Controlled Trial
The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on apnea in patients undergoing general anesthesia with rigid bronchoscopy compared with standard anesthesia methods.
- Conditions
- Foreign Bodies, Tumor, Stenosis Trachea, Bronchus Tumour
- Trial name
- NCT03892408
- Testing
- Optiflow ™
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University