Clinical trials: High-flow Nasal Oxygen Therapy
Acute Respiratory Failure Requiring Reintubation
High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period
Prospective multicenter randomized controlled open-label trial comparing 2 strategies of oxygenation during the post-extubation period in ICU patients at high risk of extubation failure.
- Trial name
- HIGH-WEAN (NCT03121482)
- Testing
- HFNC, NIV
- Where
- France
- Volunteers
- 650 people
- Sponsor
- Poitiers University Hospital
COPD
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
- Trial name
- NCT07222410
- Testing
- Closed loop oxygen control, Manual titration
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Anesthesia Induction
Oxygenation Procedure for Obese Patients During Intubation in the Operating Room
Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during…
- Trial name
- POP-OVNI (NCT06914401)
- Testing
- NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen), NIV (Non Invasive Ventilation)
- Where
- 5 sites in France
- Volunteers
- 124 people
- Sponsor
- Clinique Pasteur
Rapid Sequence Induction (RSI), Preoxygenation
High Flow Oxygen in Preoxygenation During Rapid Sequence Induction in Infants and Small Children
Airway management is crucial part of the anaesthesia. There is always a considerable risk of complications or even failure during the anaesthesia induction and airway management.
- Trial name
- PRSIHFO (NCT05846919)
- Testing
- face-mask preoxygenation, HFNOC preoxygenation, HFNOC + face-mask preoxygenation
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Desaturation of Blood
HFNC Versus Conventional Nasal Cannula in Oxygen Performance in Patients Receiving Colonoscopy Under IV Sedation
The purpose of this study is to investigate if high flow nasal cannula (HFNC), as compared to conventional nasal cannula, improves oxygenation and prevents desaturation events in obese patients undergoing colonoscopy.
- Trial name
- HFNC (NCT02968706)
- Testing
- High Flow Nasal Cannula, Conventional Nasal Cannula, Patient satisfaction questionnaire
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Aventura Hospital and Medical Center
Acute Respiratory Failure With Hypoxia, Hypoxemia
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its…
- Trial name
- DECIPHEROBS (NCT03311087)
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Hôpital Louis Mourier
Gastroscopy
High Flow Nasal Cannula in Patients Undergoing Gastroscopy
During gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce modifications to respiratory mechanics, respiratory effort and breathing pattern.
- Trial name
- NCT05693298
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Adult Patients, Requiring Intubation
PREoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation
Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients.
- Conditions
- Adult Patients, Requiring Intubation, Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200), Patient Covered by French Health Care System
- Trial name
- PREONIV (NCT01782430)
- Testing
- - standard oxygenation
- Where
- France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Respiratory Insufficiency
High Flow Nasal Oxygen Therapy in Pediatric Hypercapnic Respiratory Failure During Perioperative Stage
Humidified high flow nasal oxygen therapy decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the set FiO2 throughout the whole inspiratory phase.The purpose of this study is…
- Trial name
- NCT03534960
- Testing
- High Flow Nasal Oxygen Therapy, Nasal CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Sedation Complication, High Flow Nasal Oxygen Therapy
Impact of Sedation With HFNOT on tcPCO2, mitoPO2 and mitoVO2.
Deep procedural sedation has seen an increased use indication over the last couple of years aided by the introduction of high flow nasal oxygen therapy (HFNOT) during these procedures.
- Trial name
- NCT06124027
- Testing
- Monitoring tcPCO2 and mitoPO2
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Calvin de Wijs, MSc
MRI
MRI Study of the Gastric Insufflation After High-flow Nasal Oxygen (HFNO)
HFNO CAN BE USED AS A PREOXYGENATION TECHNIQUE BUT IS IT A SAFE TECHNIQUE IN TERMS OF GASTRIC INSUFFLATION?
- Trial name
- NCT04735276
- Testing
- HFNO for 5 min
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Liege
Diaphragm Injury, Postoperative Complications
High Flow Nasal Cannula and Diaphragmatic Function
Prospective randomized study investigating the effect of postoperative oxygen delivery on diaphragmatic function. Two different modalities of oxygen delivery will be compared: high flow nasal cannula versus standard oxygen…
- Trial name
- NCT05532033
- Testing
- High flow nasal cannula, Facial mask
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- Università degli Studi di Ferrara
Cholangiopancreatography, Endoscopic Retrograde, Hypoxia
High Flow Nasal Oxygen Versus Standard Nasal Oxygen in Endoscopic Retrograde Cholangiopancreatography Under Sedation
The administration of supplemental oxygen using a standard nasal cannula is the current standard of care for patients undergoing sedation for gastrointestinal endoscopic procedures.
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Hypoxia, Sedation
- Trial name
- NCT06689033
- Where
- Turkey (Türkiye)
- Volunteers
- 187 people
- Sponsor
- Ankara City Hospital Bilkent
Fetal Acidemia
Application of High-flow Nasal Oxygen in Cesarean Section
The study propose that the using the high-flow nasl oxygen to provide oxygen for maternal can improve the fetal acidemia and the neonatal outcomes during cesarean section with combined spinal-epidural anesthesia.
- Trial name
- NCT05921955
- Testing
- Optiflow high-flow nasal cannula system
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT
Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study
This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.
- Conditions
- Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line
- Trial name
- HiFloLUS (NCT01702779)
- Testing
- mechanical ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Post Abdominal Surgery
Comparison of HFNC and COT to Diaphragm Function of Post-upper Abdominal Surgery Patients
This study aims to compare diaphragm thickness, air lung distribution, and several clinical and laboratory parameters on post abdominal surgery patients with conventional oxygen therapy vs high-flow nasal cannula
- Trial name
- NCT04059614
- Testing
- HFNC; COT
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Post-Acute COVID-19, Post-Acute COVID-19 Infection
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection.
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Infection, Post-Acute COVID-19 Syndrome, Pulmonary Fibrosis
- Trial name
- FAPI CLIMATE (NCT05981885)
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Hypoxia, Oxygen Therapy
Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia
High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently introduced for bedside care. It has been shown to be associated with reduced risks of tracheal intubation rates and mortality in adult hypoxic…
- Conditions
- Hypoxia, Oxygen Therapy, High Flow Nasal Cannula, Ventilation
- Trial name
- NCT02943863
- Testing
- HFNC followed by conventional nasal cannula, Conventional nasal cannula followed by HFNC
- Volunteers
- 24 people
- Sponsor
- Asan Medical Center
Esophageal Cancer, Postoperative Pulmonary Atelectasis
High Flow Nasal Cannula After Esophagectomy
This study will compare the effect of HFNC versus standard oxygen administration after elective esophagectomy for cancer.
- Conditions
- Esophageal Cancer, Postoperative Pulmonary Atelectasis, Postoperative Pneumonia, Postoperative Pneumothorax
- Trial name
- OSSIGENA1V (NCT05718284)
- Testing
- AIRVO2, STANDARD CARE
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Cristian Deana