Clinical trials: High-risk Breast Cancer
Breast Cancer
Effect of Oxygen Inhalation on Fatigue After Chemotherapy of Breast Cancer in High Altitude Area
At present, there are few studies on the side effects of chemotherapy in breast cancer patients at high altitude area, and there are no studies on the relationship between oxygen inhalation and fatigue after chemotherapy in…
- Trial name
- NCT04774497
- Testing
- Oxygen inhalation treatment group, Control group
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Jiuda Zhao
Breast Cancer
Acolbifene in Preventing Cancer in Premenopausal Women at High Risk of Breast Cancer
This phase II trial is studying how well acolbifene works in preventing cancer in premenopausal women at high risk of breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT00853996
- Testing
- acolbifene hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Breast Cancer
High-Resolution Lower Dose Dedicated Breast Computed Tomography (CT)
This study is being performed to find out if a new kind of breast imaging (called dedicated breast CT or BCT) can help doctors to see the small structures in breast tissue more clearly.
- Trial name
- LowerDoseBCT (NCT03954431)
- Testing
- Dedicated breast CT(BCT)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Cancer Screening, Early Detection of Cancer
Risk Reduction Program for Women Having High Risk of Breast Cancer
An intervention program involving education, guidance, counseling, case management and surveillance based on the Health Belief Model will be implemented on women with high risk of breast cancer.
- Conditions
- Cancer Screening, Early Detection of Cancer, Breast Cancer, Preventive Health Care
- Trial name
- BrCaRRP (NCT04304404)
- Testing
- Breast Cancer Risk Reduction Program (BrCaRRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Breast Cancer
Study of Vitamin D for Premenopausal Women at High Risk for Breast Cancer
This proposal is for a pilot study of 20 premenopausal women at high risk for breast cancer development who will receive high dose vitamin D3, cholecalciferol 20,000 IU (2 capsules) weekly, or 30,000 IU (3 capsules) weekly, for 1…
- Trial name
- NCT00976339
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Katherine D. Crew
Infertility, Breast Cancer
Effects of Controlled Ovarian Hyperstimulation (COH) With Letrozole and Gonadotropin
Fertility drugs have the effect of increasing hormone levels. Higher hormone levels from infertility treatments may increase breast cancer risk, but there has not been enough research to know for sure.
- Trial name
- NCT01403688
- Testing
- RPFNA
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Breast Cancer
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy in Screening Women at Moderate-to-High Risk of Developing Breast Cancer
RATIONALE: Screening tests, such as nipple aspiration, ductal lavage, and breast duct endoscopy, may help doctors detect cancer cells early and plan more effective treatment for breast cancer.
- Trial name
- NCT00081003
- Testing
- gene expression analysis, protein expression analysis, cytology specimen collection procedure
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer
Weight Loss Plus Omega-3 Fatty Acids or Placebo in High Risk Women
The purpose of this study is to determine if high dose supplementation with the omega-3 fatty acids EPA and DHA, when added to a weight loss program, is well tolerated in the study population and if there is an increase in the…
- Trial name
- NCT02101970
- Testing
- Omega-3 Fatty Acids, Diet and Exercise
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Breast Cancer
Lifestyle Intervention for High Risk Cancer Survivors
The goal of this behavioral research study is to find out more about the health behaviors of cancer survivors. Researchers want to understand the cultural, social, and environmental factors related to physical activity and…
- Trial name
- NCT01508273
- Testing
- Exercise Program, Website, Exercise DVD
- Where
- 3 sites in United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Gd-based Contrast Media Exposure During Breast MRI Scans
Evaluation of Gadolinium Deposits in Healthy Women Participating in a High Risk Screening Program for Early Breast Cancer Detection
Purpose: To determine whether patients at high risk to develop breast cancer having received at least 6 cumulative dosages of macrocyclic Gd-based contrast media in the context of breast cancer screening by means of…
- Trial name
- NCT03393442
- Testing
- Brain MRI scan
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
High Risk for Breast Cancer
Promoting Genetic Counseling Among African American Women With a Family History of Breast Cancer
In the United States, carriers of hereditary genetic mutations have up to an 85% risk of developing breast cancer compared to 12% in the general population.
- Trial name
- NCT04378751
- Testing
- Decision aid video, Genetic counseling informational brochure
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Breast Cancer
Breast Stem Cells in Women at Average Risk and Increased Risk for Breast Cancer
Background: Research suggests that breast cancers may arise from a population of stem cells in the normal mammary gland that produce clones of cancer cells.
- Trial name
- NCT00923377
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Feasibility of Short Breast MRI (SBMRI) for Screening Patients at High Risk for Breast Cancer
The goal of this clinical research study is to test if a short breast MRI scan (about 10 minutes) can be used for breast cancer screening in high risk people and to learn if it is as effective as a routine breast MRI scan (30-60…
- Trial name
- NCT02590458
- Testing
- Short Breast MRI (SBMRI), Questionnaire
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Screening CEDM in Intermediate and High-Risk Patient Populations
This research study is being done to determine if Contrast Enhanced Digital Mammography (CEDM) can improve breast cancer detection and can be used as an additional screening method to the standard mammographic screening.
- Trial name
- NCT03859492
- Testing
- Contrast Enhanced Digital Mammography
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer
A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.
- Trial name
- CAPS (NCT03729115)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Breast Cancer
Effect of Tamoxifen on Breast Density in Premenopausal Women With Breast Cancer or High Risk for Breast Cancer
RATIONALE: High estrogen levels may be associated with dense breast tissue and an increased risk of developing breast cancer. Tamoxifen may be effective in reducing breast density by decreasing estrogen levels.
- Trial name
- NCT00086749
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Breast Cancer
Identification of Biomarkers in Women at High Risk or Average Risk of Breast Cancer
RATIONALE: Collecting and storing samples of blood and studying them in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897416
- Testing
- laboratory biomarker analysis
- Volunteers
- 1,452 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Ovarian Diseases, Ovarian Neoplasms
Cancer Screening Program for Women at High Risk for Developing Ovarian Cancer
The main purpose of this program is to see whether periodically measuring CA-125 (tumor marker) levels in the blood and undergoing transvaginal ultrasounds over time will be effective in the early detection of ovarian cancer.
- Trial name
- OCEDP (NCT01292733)
- Testing
- Laboratory Tumor Marker Analysis, Transvaginal Ultrasound, Health Status Questionnaire
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Breast Cancer
Positron Emission Mammography and Standard Mammography in Women at High Risk of Breast Cancer
RATIONALE: Screening tests may help doctors find cancer cells early and plan better treatment for breast cancer. It is not yet known whether positron emission mammography is more effective than standard mammography in finding…
- Trial name
- NCT00896649
- Testing
- questionnaire administration, digital mammography, positron emission mammography
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Breast Cancer
CEDM as a Screening Tool for Breast Cancer in Higher-risk Women: A Prospective Study
To evaluate the effectiveness of Contrast-enhanced digital mammography (CEDM) in detecting breast cancer in women at higher risk.
- Trial name
- NCT05797129
- Testing
- CEDM
- Where
- Taiwan
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.