Clinical trials: High-risk Breast Cancer
Breast Cancer Detection
Clinical Feasibility Study of Upright, Low-dose, High-resolution, 3D Breast CT (UBCT).
The investigators are doing this study to find out if a new kind of breast imaging (called upright dedicated breast CT or UBCT) can help doctors to see the small structures in breast tissue more clearly in 3-D and without…
- Trial name
- UBCT (NCT07705100)
- Testing
- Low dose, upright, dedicated breast CT
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Breast Cancer, Colorectal Cancer
Family Quality of Life Among Families With a Member Who is a Cancer Patient
RATIONALE: Developing a questionnaire that can be used to assess the quality of life among people who have a family member with cancer may help the study of cancer in the future.
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00544336
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Body Mass Index 25 or Greater, BRCA1 Gene Mutation
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
This pilot clinical trial studies different types of energy balance interventions to see how well they work in increasing the physical activity levels of breast cancer gene-positive patients, Lynch syndrome-positive patients…
- Conditions
- Body Mass Index 25 or Greater, BRCA1 Gene Mutation, BRCA2 Gene Mutation, Breast Carcinoma
- Trial name
- NCT02194387
- Testing
- Dietary Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Evaluation of a 3D Functional Metabolic Imaging and Risk Assessment System for Classifying Women at High Risk of Breast Cancer
The objective of the study is to estimate the diagnostic accuracy of cancer detection when MIRA technology is combined with mammography, by evaluating the area under the ROC curve (AUC) of mammography vs. mammography plus MIRA.
- Trial name
- NCT02777164
- Testing
- MIRA device imaging
- Where
- United States
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Real Imaging Ltd.
Neoplasms, Cancer
The STRIVE Study: Development of a Blood Test for Early Detection of Multiple Cancer Types
GRAIL is using high-intensity sequencing of circulating cell-free nucleic acids (cfNAs) to develop blood tests to detect cancer early.
- Trial name
- NCT03085888
- Where
- 35 sites in United States
- Volunteers
- 99,481 people, healthy volunteers welcome
- Sponsor
- GRAIL, Inc.
Small Breast Lesions, Dense Breast Tissue
Molecular Breast Imaging: A Novel Technology for Detection of Malignant Breast Lesions
Detection of breast cancer as early as possible is an ongoing imaging challenge.The purpose of the current study is to assess the clinical performance of the new scintigraphic technology, a dedicated breast gamma camera composed…
- Conditions
- Small Breast Lesions, Dense Breast Tissue, Discrepancy With Clinical Examination, Equivocal Mammographic, Sonographic or MRI Lesion
- Trial name
- NCT01004666
- Where
- Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
BRCA1 Mutation Carrier, BRCA2 Mutation Carrier
Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of soy isoflavones supplements may prevent or treat early stage breast cancer.
- Conditions
- BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ
- Trial name
- NCT01219075
- Testing
- soy isoflavones, questionnaire administration, magnetic resonance imaging
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Breast Cancer
Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women
RATIONALE: Chemoprevention therapy uses certain drugs to try to prevent the development or recurrence of cancer. Celecoxib may be effective in preventing breast cancer in at-risk women.
- Trial name
- NCT00056082
- Testing
- celecoxib
- Where
- 3 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Breast Cancer Related Lymphedema
Physiotherapy Program Impact on Breast Cancer-Related Lymphedema
Breast Cancer Related Lymphedema (BCRL) is a sequela resulting from the application of certain treatments, such as axillary lymph node dissection and regional lymph node radiation.
- Trial name
- NCT06491654
- Testing
- 12-week supervised exercise
- Where
- Spain
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- European University Miguel de Cervantes
Breast Cancer
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00967239
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Volunteers
- 1,881 people, healthy volunteers welcome
- Sponsor
- NSABP Foundation Inc
Malignant Tumor of Breast, Benign Breast Lumps
Implantation of CEST and CESL MRI Methods for Detection of Breast Tumors
MRI is a well-established method in breast imaging. It gives excellent morphological information but does not reflect the metabolic activity leading to high proportion of false positive results.
- Conditions
- Malignant Tumor of Breast, Benign Breast Lumps, High-Risk Breast Cancer
- Trial name
- NCT05305937
- Testing
- MRI scan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Breast Neoplasms
Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates
This multicenter trial using Hologic digital mammography units will evaluate the specificity of 2-D full field digital mammography (FFDM) versus a combination of 2-D and 3-D tomosynthesis imaging in breast cancer screening.
- Trial name
- NCT01236781
- Testing
- Screening Tomosynthesis, Diagnostic Tomosynthesis
- Where
- 2 sites in United States
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Breast Cancer
Comparison of Contrast-enhanced Spectral Mammography (CESM) to MRI in Screening High Risk Women for Breast Cancer
This research study is comparing Dual-Energy Contrast-Enhanced Spectral Mammography (CESM) to MRI as a screening tool for breast cancer.
- Trial name
- NCT02275871
- Testing
- MRI, CESM
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Breast Carcinoma
Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer
This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body…
- Trial name
- NCT04913064
- Testing
- Questionnaire Administration, White Button Mushroom Extract
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Breast Cancer
Diffusion Weighted MR Imaging of the Breasts in Women at High Risk of Breast Cancer: A Pilot Study
Purpose: The purpose of this pilot study is to evaluate whether MRI of the breasts with diffusion-weighted MR imaging can identify features more specific for breast cancer in women at high-risk of developing breast cancer.
- Trial name
- NCT01938157
- Testing
- Diffusion-weighted MR imaging
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
No Evidence of Disease, BRCA1 Syndrome
Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer
This pilot clinical trial studies a culturally-informed counseling intervention in Latinas at high risk for hereditary breast or ovarian cancer.
- Conditions
- No Evidence of Disease, BRCA1 Syndrome, BRCA2 Syndrome, Hereditary Female Breast Carcinoma
- Trial name
- NCT01230346
- Testing
- questionnaire administration, survey administration, counseling intervention
- Where
- 3 sites in United States
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Breast Cancer
Breast Cancer Screening With Diffusion-weighted MRI in Women at High Risk for Breast Cancer
A prospective observational multicenter study to compare the outcome of breast cancer surveillance using mammography, breast US, contrast-enhanced MRI, and diffusion-weighted MR imaging (DWI) as a screening tool, in the high-risk…
- Trial name
- NCT03835897
- Where
- South Korea
- Volunteers
- 890 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Feasibility Pilot Study, Compliance
A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women
This clinical trial tests whether a new dietary pattern that consists of foods that lower the blood insulin response can reduce breast cancer risk in high-risk women.
- Trial name
- LIN-BRiCK (NCT06635005)
- Testing
- Biospecimen Collection, Dietary Intervention, Medical Device Usage and Evaluation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy, no Evidence of Disease, Lobular Breast Carcinoma in Situ
Letrozole in Preventing Breast Cancer in Healthy Postmenopausal Women at High Risk for Breast Cancer
This randomized phase I trial studies the side effects and the best dose of letrozole in preventing breast cancer in healthy postmenopausal women at high risk for breast cancer.
- Trial name
- NCT01077453
- Testing
- letrozole, quality-of-life assessment, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)