Clinical trials: High-risk Medications
Benign Prostatic Hyperplasia
Composite Steep-pulseTreatment Device Used in Patients With Benign Prostatic Hyperplasia
This is a prospective, randomized, open-label, parallel-group, medication-control, superiority, multicenter clinical study trial.
- Trial name
- NCT05531344
- Testing
- Composite Steep-pulse Treatment Device, Tamsulosin Hydrochloride Capsules
- Where
- China
- Volunteers
- 160 people
- Sponsor
- REMD Medical Technology
Major Adverse Cardiovascular Events, Cardiovascular Testing and Consultation Intensity
How Institutional Guidelines for Urgent Inpatient Surgeries Affect Intensity of Perioperative Cardiovascular Testing
This study will evaluate the impact of implementing an educational clinical decision support (CDS) tool designed to guide perioperative cardiovascular evaluation for adults undergoing urgent inpatient surgery.
- Trial name
- NCT07692503
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
Healhty
Effectiveness of Artificial Intelligence Integrated Mixed Reality-based High-Alert Medications Management Simulation Program
The goal of this clinical trial is to learn if a Artificial Intelligence integrated Mixed Reality-based High-Alert Medications Management Simulation Program (AIMR-HAM) helps hospital nurses manage high-alert medicines (HAMs) more…
- Trial name
- AIMR-HAM (NCT07390461)
- Testing
- Artificial Intelligence integrated Mixed Reality-based Simulation Program, Standard medication-management education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
High Grade Upper Tract Urothelial Carcinoma
Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer
This phase II trial studies how well giving chemotherapy before surgery works in treating patients with aggressive upper urinary tract cancer.
- Trial name
- NCT02412670
- Testing
- Methotrexate, Vinblastine, Doxorubicin
- Where
- 134 sites in United States
- Volunteers
- 36 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Chemotherapy Induced Nausea and Vomiting Pediatric Cancer Patients
Efficacy and Safety of Fosaprepitant in Preventing Chemotherapy-induced Vomiting in Children Treated With Medium and High Emetic Chemotherapeutic Drugs
This study was a prospective, randomized, double-blind, parallel controlled clinical trial. The children who met the inclusion criteria and were treated with medium and high emetic chemotherapy drugs were randomly included in the…
- Trial name
- NCT05230654
- Testing
- Fosaprepitant
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Children's Medical Center
Infectious Diseases
Safety and Efficacy Study of High Dose Colistin
Colistin is a rapidly acting bactericidal antimicrobial agent that possesses a post antibiotic effect against MDRO Gram-negative bacteria, such as as Pseudomonas aeruginosa, Acinetobacterbaumannii, and Klebsiella pneumonia.
- Trial name
- NCT02162966
- Testing
- High Dose Colistin, Standard Dose Colistin
- Where
- Saudi Arabia
- Volunteers
- 330 people
- Sponsor
- King Saud Medical City
Comatose Survivors of Cardiac Arrest
High Dose of Erythropoietin Analogue After Cardiac Arrest
The investigators hypothesised that the neuroprotective effects of erythropoietin and its analogues could lead to an improve outcome after cardiac arrest.
- Trial name
- Epo-ACR-02 (NCT00999583)
- Testing
- EPOETINE ALPHA, Control arm
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Arterial Disease
Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study)
Peripheral arterial disease (PAD) occurs when arteries become narrowed or hardened because of a build-up of plaque or fat deposits.
- Trial name
- NCT00687076
- Testing
- Ezetimibe, Niaspan, Statin therapy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Baylor College of Medicine
Glioblastoma Multiforme
Vacuolar ATPase and Drug Resistance of High Grade Gliomas
GBMs are still considered tumors with few available treatment options that are able only to achieve a temporary local control of the disease.
- Trial name
- GLIODRUG-V (NCT05328089)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milano Bicocca
Healthy
A Study to Learn How Different Tablets of the Study Medicine Vepdegestrant Are Taken up Into the Blood in Healthy Adults
The purpose of the study is to compare the amount vepdegestrant available from two different tablet formulations under fed conditions in healthy adult participants; 200 mg vepdegestrant alternative tablet formulation compared to…
- Trial name
- NCT06645938
- Testing
- single dose of vepdegestrant as tablet formulation (Treatment A), single dose of vepdegestrant as tablet formulation (Treatment B)
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Health Knowledge, Attitudes, Practice
Evaluation of Educational Intervention to Teach Principles of Evidence-based Medicine (EbM) in Biology Classes
The purpose of this study is to identify the effect of a short term educational intervention for upcoming biology teachers to teach principles of Evidence-based Medicine (EbM) and Good Scientific Practice (GSP) to high-school…
- Trial name
- NCT01567267
- Testing
- Experimental educational intervention, Standard educational intervention
- Where
- Germany
- Volunteers
- 87 people
- Sponsor
- Goethe University
High-risk Medications
Testing a Medication Risk Communication and Surveillance Strategy: The EMC2 Trial
This study evaluates the effectiveness of an electronic health record based educational intervention (the EMC2 strategy) to improve patient understanding and use of higher-risk medications.
- Trial name
- NCT02785458
- Testing
- EMC2 Strategy
- Where
- United States
- Volunteers
- 1,005 people
- Sponsor
- Northwestern University
Opioid-Use Disorder, Opioid Overdose
Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose
This pilot study will evaluate the feasibility and clinical utility of extended-release injectable buprenorphine (XR-BUP) for the treatment of opioid use disorder (OUD) among individuals at high-risk for overdose (OD).
- Trial name
- FASTER-BUP (NCT04815590)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- BC Centre on Substance Use
Acute Myeloid Leukaemia, High Risk Myelodysplastic Syndrome
A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.
The AML18 Pilot Trial will evaluate the feasibility of three interventions that are planned to be included in the forthcoming NCRI AML18 Trial.
- Trial name
- AML18 Pilot (NCT01236144)
- Testing
- Plerixafor, AC220, Ganetespib
- Where
- 13 sites in United Kingdom
- Volunteers
- 113 people
- Sponsor
- Cardiff University
Acute Otitis Media
Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence
The purpose of this study is to study whether a herbal-based medication is superior to placebo for prevention of acute otitis media in pre-school children with upper respiratory tract infection.
- Trial name
- OTV_PRE_01 (NCT02345447)
- Testing
- Herbal-based medication
- Where
- Germany
- Volunteers
- 296 people
- Sponsor
- University Hospital Tuebingen
Newly Diagnosed Glioblastoma
Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma
Proposed treatment of subjects with newly diagnosed glioblastoma with novel personalized drug regimens identified to be effective in vitro using cancer stem cells derived from their individual tumors, alongside standard of care…
- Trial name
- NCT05380349
- Testing
- combinations of up to 3 FDA approved drugs from a panel of compounds
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Swedish Medical Center
Shock, Septic
COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2
The study objective is to clarify whether the application of high doses CPFA (coupled plasma-filtration adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- COMPACT-2 (NCT01639664)
- Testing
- High doses CPFA
- Where
- 13 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
General Anesthetic Drug Overdose, Adverse Effect of Intravenous Anesthetics, Sequela
Fully Automated Anesthesia, Analgesia and Fluid Management
Evaluate the feasibility and quality of automated anesthesia, analgesia and fluid management based on a combination of several physiological variables (bispectral index [BIS], stroke volume [SV], and stroke volume variation…
- Conditions
- General Anesthetic Drug Overdose, Adverse Effect of Intravenous Anesthetics, Sequela, Complication of Anesthesia, Drug Delivery System Malfunction
- Trial name
- NCT02886806
- Testing
- BIS XP, Covidien, Ireland, EV-1000 TM, Edwards Lifesciences, Irvine, California, USA
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Erasme University Hospital
Hepatic Echinococcosis
5G Remote Robotic Surgery for Hepatic Echinococcosis in High-Altitude Region
Hepatic echinococcosis (HE) is a serious endemic parasitic disease in high-altitude regions like Xizang. Radical hepatectomy is the primary curative treatment, but expert resources are often concentrated in large medical centers.
- Trial name
- HAT (NCT07551063)
- Testing
- 5G-based Telerobotic Hepatectomy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- West China Hospital
Hypertension
One-Year Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension
This purpose of this study is to evaluate the long-term safety and tolerability of azilsartan medoxomil in individuals with essential hypertension.
- Trial name
- NCT00695955
- Testing
- Azilsartan medoxomil with or without add-on chlorthalidone, Azilsartan medoxomil with or without add-on hydrochlorothiazide
- Where
- 41 sites in United States, Chile and 1 more
- Volunteers
- 669 people
- Sponsor
- Takeda