Clinical trials: High-risk Medications
High Blood Pressure
Verification of the Efficacy and Safety of the BAROSTIM NEO System in the Treatment of Drug Resistant Hypertension
To assess the long-term safety and efficacy of the BAROSTIM NEO System in trial (NCT01471834) participants.
- Trial name
- NCT01471834
- Testing
- BAROSTIM NEO System, Medical Management
- Where
- 9 sites in Canada, Germany and 1 more
- Volunteers
- 40 people
- Sponsor
- CVRx, Inc.
Brain and Central Nervous System Tumors, Cerebral Edema
Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme
RATIONALE: Giving the herb Boswellia serrata after surgery and radiation therapy may slow the growth of any remaining tumor cells.
- Trial name
- NCT00243022
- Testing
- Boswellia serrata extract, cyanocobalamin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ali Altunkaya
Osteosarcoma
Patient-derived Xenograft (PDX) Modeling to Test Drug Response for High-grade Osteosarcoma
By obtaining clinical specimens from participants with high-grade bone and soft tissue sarcomas to establish and profile as freshly implanted tumors in mice, the aim of this study is to identify agents with predicted activity in…
- Trial name
- NCT03358628
- Testing
- Molecular Profiling & In Vivo drug testing in PDX
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
HER2-negative Breast Cancer, Triple Negative Breast Cancer
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
Phase III, prospective, multi-center, randomized, open label, parallel group, study in patients with HER2-negative breast cancer with residual disease after neoadjuvant chemotherapy with 1:1 allocation to: Arm A: Sacituzumab…
- Trial name
- SASCIA (NCT04595565)
- Testing
- Capecitabine, Carboplatin, Cisplatin
- Where
- 163 sites in Austria, Belgium and 5 more
- Volunteers
- 1,332 people
- Sponsor
- GBG Forschungs GmbH
Bipolar Disorder
High Deductible Health Plans and Bipolar Disorder
Using eleven years (2004-2014) of claims data from the largest US commercial health insurer, the investigators will assess the impact of switching into high-deductible health plans (HDHPs) on outcomes for patients with bipolar…
- Trial name
- NCT02560701
- Testing
- Patient Interview
- Volunteers
- 350,823 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Hypertension
Community Hypertension Assessment Trial (CHAT)
The Community Hypertension Assessment Trial (CHAT) is an investigation of the effect of community pharmacy based blood pressure (BP) monitoring sessions led by peer health educators, with feedback to family physicians, on the…
- Trial name
- NCT00217334
- Testing
- Volunteer-led pharmacy sessions with feedback to physicians
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Angina Pectoris, Acute Coronary Syndrome
Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19
Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure…
- Conditions
- Angina Pectoris, Acute Coronary Syndrome, Coronary Syndrome, Coronary Artery Disease
- Trial name
- eCardioCovid19 (NCT04325867)
- Testing
- Tele-medicine platform
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic
Emergencies
The Greek Acute Dance Injuries Registry
Dance is a highly demanded physical activity with a high rate of acute and emergent events (AEE). No systematic prospective study has been conducted in any Greek population of dance students for the registration of the AEE and…
- Trial name
- GrADIR (NCT06220916)
- Testing
- Dance training in Classical Ballet and Contemporary Dance
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Systemic Hypertension, Obesity
GAstric Bypass to Treat obEse Patients With steAdy hYpertension
Phase 3, unicentric, randomized clinical trial, with allocation concealment and intention-to-treat analysis to evaluate the efficacy of videolaparoscopic Roux-en-Y Gastroplasty to decrease the prescription of antihypertensive…
- Trial name
- GATEWAY (NCT01784848)
- Testing
- Laparoscopic Roux-en-Y gastric bypass (LRYGB), Clinical treatment
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital do Coracao
Antimicrobial Drug Resistance, High-Throughput Nucleotide Sequencing
The Predictive Value of Molecular Diagnostic Techniques in the Antimicrobial- Resistance Phenotypes of Pathogens
This observational study is to learn about the predictive value of targeted next-generation sequencing(tNGS) in pathogen resistance phenotype of patients with lower respiratory tract infection ,by detecting…
- Trial name
- NCT07035535
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HER2-positive Breast Cancer, Targeted Therapy
Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude
This is a prospective, multicenter, cohort study aiming to explore the cardiotoxicity of targeted therapy for HER-2 positive breast cancer patients who lives in high altitude area.
- Conditions
- HER2-positive Breast Cancer, Targeted Therapy, Cardiac Toxicity, High Altitude
- Trial name
- NCT05063643
- Testing
- High altitude
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Affiliated Hospital of Qinghai University
NSCLC
High Throughput Screening Device Based on 3D Nano-matrices and 3D Tumors With Functional Vascularization
Almost 85% of new therapeutic molecules are abandoned before the clinical trial stage. Most of these failures currently concern cancer therapies.
- Trial name
- TUMOVASC (NCT04826913)
- Testing
- Organoids
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
HIV Infections
Improving Treatment and Retention Adherence in Nontraditional Settings
This is a hybrid implementation-effectiveness study using both qualitative and quantitative methods. The research aims to examine whether providing a new, but approved, HIV once a month injection treatment…
- Trial name
- I-TRAINS (NCT04973254)
- Testing
- CAB-RPV LA, Standard treatment within an HIV clinic
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boston Medical Center
Comatose Survivors of Cardiac Arrest
High Dose of Erythropoietin Analogue After Cardiac Arrest
The investigators hypothesised that the neuroprotective effects of erythropoietin and its analogues could lead to an improve outcome after cardiac arrest.
- Trial name
- Epo-ACR-02 (NCT00999583)
- Testing
- EPOETINE ALPHA, Control arm
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Human Immunodeficiency Virus Exposure, Alcohol; Harmful Use
Game Plan for PrEP
This small pilot randomized controlled trial will test whether a brief, web-based intervention inspired by the principles of motivational interviewing helps high-risk men who take pre-exposure prophylaxis (PrEP) moderate their…
- Trial name
- NCT04973267
- Testing
- Game Plan for PrEP, Attention-Matched Control Lifestyle Habits Videos
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Brown University
Psychosis
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
Background Psychosis is a mental health condition that affects around 3 in 100 people in their lifetime. Most treatments for psychosis target a brain chemical called dopamine but they don't work for everyone and don't address…
- Trial name
- LEVHIPPRO (NCT06224530)
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- King's College London
Non-small Cell Lung Cancer Metastatic
SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients
Open label multicentric randomized phase II trial, using high throughput genome analysis as a therapeutic decision tool, aimed at comparing a targeted treatment administered according to the identified molecular anomalies of the…
- Trial name
- SAFIR02_Lung (NCT02117167)
- Testing
- AZD2014, AZD4547, AZD5363
- Where
- 37 sites in France
- Volunteers
- 999 people
- Sponsor
- UNICANCER
Head and Neck Surgery, Chronic Sinusitis
Sugammadex v.s. Neostigmine/Glycopyrrolate
The aim of study is to clarify the role of sugammadex in ENT surgery patients with a prior history of postoperative urinary retention, benign prostatic hypertrophy, or a history of prostate cancer, to prevent postoperative…
- Conditions
- Head and Neck Surgery, Chronic Sinusitis, Chronic Otitis Media, Laryngeal Disease
- Trial name
- NCT06398899
- Testing
- Group S: sugammadex injection, Group N: neostigmine/glycopyrrolate
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
HIV Infections
Implementation and Assessment of a Medication Therapy Management Program in HIV Patients at High Risk of Adverse Drug Events at Khartoum, Sudan
This clinical trial aims to evaluate the effectiveness and cost-effectiveness of two levels of a pharmacist-led Medication Therapy Management (MTM) program, Basic MTM and Enhanced MTM, compared with usual care for HIV patients at…
- Trial name
- HIV-MTM-SUDAN- (NCT07750834)
- Testing
- Basic MTM, Enhanced MTM
- Where
- Sudan
- Volunteers
- 1,149 people
- Sponsor
- Universiti Sains Malaysia