Clinical trials: High-risk Pregnancy
Bladder, Neurogenic
PK/PD, Long-term Safety and Efficacy of Tamsulosin Treatment in Children With Neurogenic Bladder
Aims of this study is to characterize the pharmacokinetic/pharmacodynamic profile and evaluate the safety, efficacy and tolerability, of tamsulosin hydrochloride as treatment in children with a neuropathic bladder, over the…
- Trial name
- NCT00340704
- Testing
- tamsulosin hydrochloride
- Where
- 72 sites in United States, Belgium and 12 more
- Volunteers
- 143 people
- Sponsor
- Boehringer Ingelheim
Ovarian Cancer
Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy…
- Trial name
- NCT00002819
- Testing
- carboplatin, cyclophosphamide, mitoxantrone hydrochloride
- Where
- 64 sites in United States
- Sponsor
- Gynecologic Oncology Group
Pre-eclampsia, Obesity
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Obesity is a growing problem in East London and every other woman who enters pregnancy is obese or overweight. In addition to obesity, other metabolic risk factors such as raised lipids, high blood pressure and diabetes increase…
- Conditions
- Pre-eclampsia, Obesity, Raised Lipids, High Blood Pressure
- Trial name
- ESTEEM (NCT02218931)
- Testing
- Targeted ESTEEM diet, Non-randomised cohort
- Where
- United Kingdom
- Volunteers
- 3,442 people
- Sponsor
- Queen Mary University of London
High Grade Intraepithelial Neoplasia, Cervix Cancer
Randomized Clinical Trial Evaluating the Efficacy of Topical Imiquimod in High Grade Cervical Intraepithelial Lesions
Cervical cancer is one of the leading malignancies affecting women, with 311,000 deaths in 2018, most of them seen in underdeveloped countries.
- Trial name
- NCT03233412
- Testing
- Control, Imiquimod
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Barretos Cancer Hospital
Death, Stroke
Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients
Remote ischemic preconditioning (RIPC) occurs when a tissue (ex. heart) becomes less vulnerable to an ischemic insult if a remote tissue (ex. arm) has had previous exposure to a period of ischemia and reperfusion.
- Conditions
- Death, Stroke, Low Cardiac Output Syndrome, Myocardial Infarction
- Trial name
- NCT01328912
- Testing
- Remote ischemic preconditioning stimulus, control
- Where
- Canada
- Volunteers
- 429 people
- Sponsor
- Queen's University
End-stage Renal Disease
Solute Removal With High Volume Hemodiafiltration Versus Long High Flux Hemodialysis
This is a prospective cross-over study including 10 stable hemodialysis patients with chronic kidney disease stage 5. The cross-over study lasts 2 weeks with the study dialysis sessions at midweek.
- Trial name
- NCT01445366
- Testing
- High volume post dilution hemodiafiltration, high flux hemodialysis
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Ghent
High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
This study will test the safety, including side effects, and determine the characteristics of a drug called Rina-S in participants with solid tumors.
- Conditions
- High Grade Epithelial Ovarian Cancer, High Grade Serous Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
- Trial name
- RAINFOL-01 (NCT05579366)
- Testing
- Rina-S, Carboplatin, Bevacizumab
- Where
- 66 sites in United States, China and 1 more
- Volunteers
- 952 people
- Sponsor
- Genmab
Uterine Cervical Neoplasms
A Chinese Cohort of Cervical Large Cell Neuroendocrine Carcinoma
Cervical large cell neuroendocrine carcinoma (LCNEC) exhibits highly aggressive biological behavior, including strong invasiveness, a high propensity for metastasis, drug resistance, and poor prognosis, necessitating heightened…
- Trial name
- CN-CLCNEC (NCT07240753)
- Testing
- Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
- Volunteers
- 200 people
- Sponsor
- Lili
Increased Nuchal Translucency in the First Trimester of Pregnancy
Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
The study is based on the hypothesis that increased nuchal translucency may be associated with a materno fetal infection and that the pathogen responsible for this infection could be identify with metatranscriptomic…
- Trial name
- METAHCN (NCT05388968)
- Testing
- Metatranscriptomic, Specific microbiologic diagnosis
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bladder Cancer, Bladder Cancer Recurrence
Multiplex Mutation Detection Using Mass Spectrometry in Bladder Cancer
Bladder cancer is a highly heterogeneous malignancy characterized by frequent genetic alterations that are closely associated with disease progression, recurrence risk, and treatment response.
- Conditions
- Bladder Cancer, Bladder Cancer Recurrence, Adjuvant Therapy for Bladder Cancer, Progression of Bladder Cancer
- Trial name
- NCT07424560
- Testing
- Multiplex Mutation Detection System for Bladder Cancer (Nucleic Acid Mass Spectrometry)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhilong Dong
Gestational Diabetes Mellitus in Second Trimester of Pregnancy
Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy
1. To assess the value of serum Pentraxin-3 and high sensitive CRP in females with normal pregnancy and females with gestational diabetes mellitus in second trimester of pregnancy. 2.
- Trial name
- NCT05846191
- Testing
- serum pentraxin 3 and high sensitive CRP
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ovarian Cancer, Fallopian Tube Cancers
Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance
The goal of this retrospective observational study is to evaluate the relationship between different dietary patterns (specifically low-carbohydrate diets) and the prognosis of patients with high-grade serous ovarian cancer…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Carcinoma, High-grade Serous Ovarian Cancer
- Trial name
- NCT07269574
- Volunteers
- 600 people
- Sponsor
- Tongji Hospital
Kidney Failure, Frailty
A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF)
The goal of this clinical trial is to compare protein supplements in patients with kidney failure on dialysis. The main questions it aims to answer are: To determine whether the supplementation of egg white protein pudding in a…
- Conditions
- Kidney Failure, Frailty, Kidney Disease, Chronic
- Trial name
- NCT06343727
- Testing
- Egg white protein pudding, : Ensure Plus
- Where
- 2 sites in Canada
- Volunteers
- 54 people
- Sponsor
- Seven Oaks Hospital Chronic Disease Innovation Centre
Clear Cell Renal Cell Carcinoma
Cadonilimab Combination With Lenvatinib as Neoadjuvant Therapy for ccRCC
Through the neoadjuvant treatment with a combination of Cadonilimab and Lenvatinib, it enabled the successful and safe implementation of partial nephrectomy in patients with localized renal cancer, who had indications for…
- Trial name
- NCT06138496
- Testing
- Cadonilimab Combined With Lenvatinib
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Sun Yat-sen University
Bleeding Disorder, Stroke, Ischemic
XIENCE 28 Global Study
XIENCE 28 Global Study is a prospective, single arm, multi-center, open label, non-randomized trial to further evaluate the safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of…
- Conditions
- Bleeding Disorder, Stroke, Ischemic, Stroke Hemorrhagic, Hematological Disease
- Trial name
- NCT03355742
- Testing
- XIENCE, DAPT
- Where
- 52 sites in Austria, Belgium and 11 more
- Volunteers
- 963 people
- Sponsor
- Abbott Medical Devices
Postpartum Hemorrhage
Fever After Misoprostol Administration for the Treatment of Primary Postpartum Hemorrhage
This study will evaluate side effects after sublingual misoprostol (600 mcg) as a first-line treatment for primary postpartum hemorrhage (PPH) due to suspected uterine atony.
- Trial name
- NCT01080846
- Testing
- Misoprostol
- Where
- Ecuador
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Recurrent Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8
Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy
This phase III trial compares the effect of adding gemcitabine to intravesical Bacillus Calmette Guerin (BCG) versus intravesical BCG alone in patients with non-muscle invasive bladder cancer that has come back after a period of…
- Conditions
- Recurrent Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8, Stage I Bladder Cancer AJCC v8
- Trial name
- GAIN-BCG (NCT07000084)
- Testing
- BCG Solution, Biopsy of Bladder, Cystoscopy
- Where
- 60 sites in United States
- Volunteers
- 330 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Renal Stones
Ureteroscopic Lithotripsy for Renal Stones Using a Sheathless Approach or Using a Flexible and Navigable Ureteral Access Sheath (FANS)
The primary aim of the study is to compare stone free rates following ureteroscopic (URS) lithotripsy for renal stones with Thulium Fiber Laser (TFL) using a sheathless approach (low power laser settings) or using a flexible and…
- Trial name
- NCT07741084
- Testing
- Sheathless URS, FANS, low power, FANS, high power
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Haukeland University Hospital
Pneumonia, Urinary Tract Infection
Identification of Admission High Risk Elderly
Objective: The study aim to establish high risk admission model and readmission model for elderly in Taiwan. Method: Investigators compare the clinical, epidemiological, and socioeconomic characteristics of admitted patients…
- Conditions
- Pneumonia, Urinary Tract Infection, Stroke
- Trial name
- NCT01934426
- Where
- Taiwan
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Preeclampsia
Consumption of Chocolate in Pregnant Women.
The purpose of this study is to investigate the acute and chronic effect of consumption of flavanol-rich chocolate on endothelium function in pregnant women at high risk for preeclampsia.
- Trial name
- CHOCENTA (NCT01431443)
- Testing
- Flavanol-rich chocolate
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Laval University
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