Clinical trials: Hip Infection
Staphylococcal Infections
Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection
To determine the outcome and safety of a combined antimicrobial treatment involving daptomycin and surgical approach involving retention or short-interval two-stage exchange of the implant.
- Trial name
- Dapto-Studie (NCT01144000)
- Testing
- Daptomycin
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Andrej Trampuz
Infected of Hip or Kneeprosthesis
β-lactam Use in Single-stage Exchange of ProstheTic Infections (Knee / Hip) in a Center of Reference (β-SEPTIC)
According to the official recommendations, infected prosthesis can be surgically treated by one or two-stage replacement. In Strasbourg, the investigators only perform one-stage surgery, which means that the new materiel is put…
- Trial name
- β-SEPTIC (NCT04123964)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Periprosthetic Fracture Around Prosthetic Joint Implant
Investigating Periprosthetic Fracture Cultures in Arthroplasty
This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment…
- Trial name
- NCT06952738
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Implant Infection, Skeletal Sarcoma
Implant-Related Infections in Patients With Skeletal Sarcomas
The aim of this observational study is to gain knowledge on the microbial and immunological factors behind implant-related infections in patients with skeletal sarcoma.
- Conditions
- Implant Infection, Skeletal Sarcoma, Hip Arthritis, Prosthesis-Related Infections
- Trial name
- IRISSAR (NCT07264296)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Arthroplasty, Hip Replacement, Infection, Postoperative Wound
Efficacy of Surgical Skin Preparation Solutions in Hip Arthroplasty Surgery
This study will assess the efficacy of two of the most commonly used surgical skin-preparation solutions: Chloraprep (chlorhexidine-alcohol) and Duraprep (iodine-alcohol) at eliminating bacteria from the hip site by evaluating…
- Trial name
- NCT03393819
- Testing
- DuraPrep, ChloraPrep
- Volunteers
- 105 people
- Sponsor
- Lakehead University
Osteoarthritis, Hip Infection
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Infection remains one of the most difficult-to-treat complications of total hip arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.The first stage…
- Conditions
- Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- SPACERHIP (NCT01373099)
- Testing
- Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rush University Medical Center
Disorder of Hip Region
A Ten-state Cluster-randomized Controlled Trial of the Institute for Health Improvement's Project JOINTS
In 2011, IHI designed a new campaign to accelerate uptake of evidence-based practices that had been shown to prevent surgical site infections (SSI) associated with hip and knee arthroplasty.
- Trial name
- NCT02886741
- Testing
- Quality Improvement Campaign
- Volunteers
- 549 people
- Sponsor
- RAND
Hip Prosthesis Infection
Does the Type of Ventilation Affect the Risk for Infections After Hip Replacements?
Background: During hip replacement surgery, there is a risk that bacteria in the operating room can cause an infection. To try and reduce this risk, some operating rooms use a special system called laminar airflow (LAF), which…
- Trial name
- NCT05932823
- Testing
- Laminary airflow
- Volunteers
- 110,000 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Arthropathy of Hip, Arthropathy of Knee
Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
- Trial name
- NCT03365323
- Testing
- Periprosthetic Joint Infection, Non-Periprosthetic Joint Infection
- Volunteers
- 160 people
- Sponsor
- Peking University People's Hospital
Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis
Topical Vancomycin for Infection Prophylaxis in TJA
11% of the general population undergo total hip arthroplasty (THA) in their lifetime and 7% undergo total knee arthroplasty (TKA), with these rates expected to rise up to 50% by 2026.
- Trial name
- NCT04993027
- Testing
- Vancomycin Powder
- Volunteers
- 100 people
- Sponsor
- Alberta Hip and Knee Clinic
Arthritis of the Hip, Transfusion Related Complications
Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)
The purpose of this study is to determine if there are differences in clinical events, i.e bleeding with associated morbidity, if thromboprophylaxis with LMWH (Low Molecular Weight Heparin) is initiated before or after surgery.
- Conditions
- Arthritis of the Hip, Transfusion Related Complications, Infection, Wound Discharge
- Trial name
- NCT01714297
- Testing
- dalteparin 5000 IU s.c.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Prosthetic-joint Infection, Infection Hip
Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin…
- Conditions
- Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint
- Trial name
- RiCOTTA (NCT06172010)
- Testing
- Clindamycin, Rifampicin and levofloxacin
- Where
- 13 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- Leiden University Medical Center
Prosthesis-related Infections, Wound Complications
Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.
The purpose of this study is to determine the efficacy of a negative pressure wound therapy (NPWT) system after revision total knee and hip arthroplasty in patients at high risk for infection.
- Conditions
- Prosthesis-related Infections, Wound Complications, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02127281
- Testing
- Prevena
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The Cleveland Clinic
Prosthetic Joint Infections of Hip
Bacteriophage Therapy for Morganella Morganii Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Morganella morganii prosthetic joint infection of the hip.
- Trial name
- PHAGE-MOM-001 (NCT06814756)
- Testing
- phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic
Prosthesis Related Infections
Biodistribution and Dosimetry Evaluation of [124I]FIAU
This protocol will evaluate the biodistribution and dosimetry of [124I]FIAU in both healthy volunteers and patients with prosthetic joint infections.
- Trial name
- NCT01337466
- Testing
- [124I]FIAU
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- BioMed Valley Discoveries, Inc
Lumbar Spondylitis
Thoracic Mobility Versus Hip Mobility Exercises to Core Stabilization in Lumbar Spondylitis
This study is conducted to determine the effect of thoracic mobility versus hip mobility exercises to core stabilization on pain severity (NPRS-Ar), functional disability (MODI-Ar), lumbar range of motion (BROM), spinal mobility…
- Trial name
- TME-HME (NCT07482527)
- Testing
- Group A : Core stabilization exercises (control group), Group B: Thoracic Mobility Exercises (1st experimental group only), Group C: Hip Mobility Exercises (2nd experimental group only)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
HIV, HIV-Infections
The Visceral Adiposity Measurement and Observation Study
The Visceral Adiposity Measurement and Observation Study
- Conditions
- HIV, HIV-Infections, HIV-1-infection, HIV I Infection
- Trial name
- VAMOS (NCT05383456)
- Testing
- Diagnostic Test, HIV Anti-retroviral Background Therapy
- Where
- 8 sites in United States
- Volunteers
- 196 people
- Sponsor
- Theratechnologies
Infection
Bacterial Contamination of Operative Splash Basins
The primary objective of this study is to compare the efficacy of adding 0.05% chlorhexidine gluconate to the splash basin in reducing bacterial growth from splash basins at the end of a total joint replacement procedure.
- Trial name
- NCT02434510
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Utah