Clinical trials: Hip Infection
Direct Infection of Hip- and Knee Arthroplasty
Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study
Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks)…
- Trial name
- DAIR (NCT02087020)
- Testing
- Debridement, antibiotics and implant retention
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Danderyd Hospital
Bone and Joint Infection, Bacterial Infections
Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
- Conditions
- Bone and Joint Infection, Bacterial Infections, EPIDEMIOLOGY
- Trial name
- NCT03627000
- Testing
- failure after reimplantation
- Volunteers
- 114 people
- Sponsor
- Hospices Civils de Lyon
Osteoarthritis, Hip, Osteoarthritis, Knee
Total Joint Arthroplasty (TJA) Weight Loss Study
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
- Trial name
- NCT05156762
- Testing
- Bariatric surgery, Medical weight loss, Patient research surveys
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Joint Infection, Infection of Hip Joint (Disorder)
Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis
Differentiating between septic arthritis and other causes of joint inflammation in pediatric patients is challenging and of the utmost importance because septic arthritis requires surgical debridement as part of the treatment…
- Conditions
- Joint Infection, Infection of Hip Joint (Disorder), Infection of Shoulder Joint, Septic Arthritis
- Trial name
- NCT03704766
- Testing
- Synovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay
- Where
- 3 sites in United States
- Volunteers
- 442 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee, Osteoarthritis, Hip
Wound Closure Materials and Techniques in Hip and Knee Arthroplasty
This prospective randomized clinical study aims to evaluate the effects of different suture materials and wound closure techniques on wound healing, functional outcomes, and postoperative complications in patients undergoing…
- Trial name
- NCT07439575
- Testing
- Barbed Suture Wound Closure, Conventional Suture Wound Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bahattin Kemah
Osteoarthritis, Knee, Osteoarthritis, Hip
Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty
The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip
- Trial name
- NCT05972603
- Testing
- 1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Independent Public Healthcare Center in Rypin
Orthopaedics Wound Dressings
Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care
Title: Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care: A Randomized Controlled Trial Objective: The primary objective of this study is to evaluate and compare the efficacy of…
- Trial name
- NCT06540040
- Testing
- Aquacel Ag, OPSITE, MEPILEX POST OP BORDER
- Where
- India
- Volunteers
- 320 people
- Sponsor
- Nidhi Srivastava
Chronically Infected Total Hip of Knee Prosthesis
Cost-effectiveness Evaluation of One Stage Versus Two Stage Exchange for Chronically Infected Total Hip and Total Knee Prostheses
Chronic infection after total joint arthroplasty generally requires implant exchange. Two stage exchange is considered as the gold standard procedure. However, some authors suggest that one stage exchange may be as effective.
- Trial name
- IPRO (NCT02651961)
- Testing
- Exchange of total hip or knee arthroplasty on same time, Exchange of total hip or knee arthroplasty in two time
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- ACTIVE2 (NCT05269134)
- Testing
- Bacteriophage
- Where
- 10 sites in United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Prosthetic Joint Infection, Bacterial Infections
Bacteriophage Therapy in First Time Chronic Prosthetic Joint Infections
This study will test the feasibility of a regimen of intraoperative (IO) and intravenous (IV) PhageBank™ bacteriophage therapy in conjunction with a DAIR procedure to cure chronic prosthetic joint infection (PJI) without…
- Trial name
- ACTIVE1 (NCT05269121)
- Testing
- Phage Therapy
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Hip Prosthesis Infection, Arthroplasty Complications
DAIR for Infected Total Hip Arthroplasty - Does the Operative Approach Influence the Functional Result?
The functional outcome and quality of life after treatment for an infected hip arthroplasty have been found to be significantly worse compared to an uncomplicated arthroplasty.
- Trial name
- NCT03161990
- Testing
- Transgluteal approach to the hip joint, Posterior approach to the hip joint
- Where
- Norway
- Volunteers
- 226 people
- Sponsor
- University Hospital, Akershus
Surgical Wound Infection
Preoperative Bath in Patients Submitted to Hip Arthroplasty
Clinical trial for prevention, randomized, controlled, blinded, parallel, with three arms which purpose is verify the effects of nursing intervention preoperative bathing with 4% chlorhexidine gluconate, 10% Povidone iodine…
- Trial name
- NCT03001102
- Testing
- 4% Chlorhexidine gluconate, 10% PVPI degermante, Soap without antiseptic
- Where
- Brazil
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Flu, Common Cold
A Double-blind, Randomised, Parallel Group,Comparative Study With Rose-hip Liquid and Placebo Given to Healthy Volunteers in the Winter Season Aiming to Evaluate the Occurences of Flu and Catching a Cold
The trial is an investigator-initiated, double-blind, randomized, placebo-controlled phase III study. After the patient has receiving information about the study and after given written informed consent, the patient will be…
- Trial name
- NCT01459952
- Testing
- Rose hip Liquid
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hyben Vital ApS
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
Prosthetic Joint Infection
Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation
Study Type Prospective, single-arm, open-label, multicenter (3 to 5 sites), interventional trial. Primary Study Objective The objective of the study is to determine the safety profile of local antibiotic irrigation for the…
- Trial name
- NCT03721328
- Testing
- vancomycin hydrochloride and tobramycin sulfate
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Osteal Therapeutics, Inc.
Prosthetic Joint Infection
Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers
Total joint replacement (TJR) is an increasing effective procedure in orthopedics. However, TJR failure due to aseptic or septic loosening remains an important problem, often due to predisposing factors of the patient, which…
- Trial name
- DECISION (NCT04858217)
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Istituto Ortopedico Rizzoli
Revision Total Hip Arthroplasty (RTHA), Revision Total Knee Arthroplasty
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
The goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery…
- Trial name
- CLEANJoint (NCT05828810)
- Testing
- Chlorhexidne Gluconate-Alcohol Skin Preparation, Poviodine-iodine Skin Preparation
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Surgical Site Infection, Hip Fractures
Wound Contamination During Orthopaedic Surgery
In the present study we will compare bacteriological findings and the incidence of SSI in relation to laminar airflow (LAF) ventilated ORs, conventional (also called displacement or mixed) ventilated ORs and conventional…
- Conditions
- Surgical Site Infection, Hip Fractures, Orthopedic Disorder, Implant Infection
- Trial name
- Clean Care (NCT04676841)
- Testing
- Conventional ventilation + instrumental tables with integrated laminar airflow, Conventional ventilation + standard instrumental tables, Laminar airflow ventilation + standard instrumental tables
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Vastra Gotaland Region
Prosthetic-joint Infection
SHort Interval Full Two-stage Implant Exchange
This study is a prospective bicentric feasibility study, which aims to evaluate the feasibility of a two-stage full implant exchange with early prosthesis reimplantation between 16 and 30 days after implants removal for hip or…
- Trial name
- SHIFT (NCT05642013)
- Testing
- Early prosthesis reimplantation, Retrospective analysis of medical records
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier