Clinical trials: Hip Replacement Surgery
Neuromuscular Blockade, Innate Inflammatory Response
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
- Conditions
- Neuromuscular Blockade, Innate Inflammatory Response, Quality of Life, Postoperative Complications
- Trial name
- HIPPO (NCT05562999)
- Testing
- Rocuronium Bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Venous Thromboembolism, Arthroplasty, Replacement, Hip
A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery
The purpose of this study is to evaluate the efficacy and safety of various doses of YM150 (the experimental drug) compared to enoxaparin in the prevention of venous thromboembolism in patients that are undergoing elective hip…
- Trial name
- ONYX-3 (NCT00902928)
- Testing
- YM150, enoxaparin
- Where
- 156 sites in United States, Australia and 26 more
- Volunteers
- 1,992 people
- Sponsor
- Astellas Pharma Europe B.V.
Obturator Nerve Block, Total Hip Replacement
Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade
The study investigates the effect of an obturator nerve block on the postoperative pain and opioid consumption after total hip replacement.
- Trial name
- NCT03064165
- Testing
- Bupivacaine-epinephrine, Obturator nerve block, Sodium Chloride 9mg/mL
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- University of Aarhus
Regional Anesthesia Block, Regional Anesthesia
PENG and LFCN Block Versus FIC Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis Focused on Movement (Retro-PvF)
Total hip arthroplasty is a major surgical procedure performed on a growing number of patients. Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation, thus…
- Conditions
- Regional Anesthesia Block, Regional Anesthesia, Total Hip Replacement Surgery, Total Hip Arthroplasty \(THA\)
- Trial name
- Retro-PvF (NCT06342102)
- Testing
- PENG + LFCN block, FIC block
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Edoardo Bassini
Perioperative Neurocognitive Disorders
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling
The term perioperative neurocognitive disorders (PND) is derived from postoperative cognitive dysfunction (POCD), and has been renamed as PND in recent years in accordance with the latest international consensus.
- Trial name
- NCT07652008
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Venous Thromboembolism
Dose Ranging Study in Elective Total Hip Replacement Surgery
The primary objective is to: demonstrate the efficacy of SR123781A in the prevention of venous thromboembolism (VTE) by the demonstration of a dose-response in patients undergoing total hip replacement surgery.
- Trial name
- DRIVE (NCT00338897)
- Testing
- SR123781A
- Where
- 14 sites in Argentina, Bulgaria and 12 more
- Volunteers
- 1,090 people
- Sponsor
- Sanofi
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Total Hip Replacement, Arthroplasty Complications
REVISITS: Revision Single or Two Stage Surgery
Hip replacement surgery is common, with over 60,000 cases in Canada annually. After hip replacement, about 1-2% patients develop a deep infection in their artificial hip implant, called a periprosthetic joint infection (PJI).
- Trial name
- REVISITS (NCT03741296)
- Testing
- Single stage revision, Two-stage revision
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Total Hip Replacement
Study of Total Hip Arthroplasty Using Radlink Surgical Positioning Software
This is a prospective, randomized study of total hip arthroplasty with and without the use of Radlink surgical positioning software.
- Trial name
- NCT02536573
- Testing
- Radlink Surgical Positioning Software
- Volunteers
- 200 people
- Sponsor
- Anderson Orthopaedic Research Institute
Blood Loss, Surgical
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement
This study compares two oral medications (tranexamic acid and aminocaproic acid) as hemostatic agent administered in patients undergoing primary total hip replacement
- Trial name
- NCT04187014
- Testing
- Aminocaproic Acid 1000Mg Tab, Tranexamic acid tablets
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Carlos A Acosta-Olivo
Aortic Diseases, Osteoarthritis, Hip
Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery.
- Trial name
- KEEP-HB (NCT00851149)
- Testing
- Sangvia blood sampling system
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset i Vestfold HF
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery.
- Trial name
- NCT01103752
- Testing
- no intervention, descriptive study
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Lene Krenk
Proximal Femoral Metastases
A Randomized Trial to Assess Patient Quality of Life and Function After Alternative Surgeries for Pathologic Fractures of the Femur
The purpose of this study is to look at two different types of surgeries regularly used for treating cancer that has spread to and weakened the thigh bone (femur).
- Trial name
- NCT02164019
- Testing
- long-stem cemented hemiarthroplasty (LSCH), intramedullary nailing (IMN), questionnaires
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Type 2 Diabetes, Hip Osteoarthritis
DexCom Hospital Study-CGM Directed Insulin Delivery
This is a pilot investigator initiated/sponsored clinical trial to evaluate the feasibility of using real-time DexCom G6 continuous glucose monitor (CGM or glucose sensor) trend data and an insulin-dosing algorithm to control the…
- Conditions
- Type 2 Diabetes, Hip Osteoarthritis, Knee Osteoarthritis
- Trial name
- NCT05504785
- Testing
- DexCom G6 continuous glucose monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Acupuncture, Hip Surgery
Incorporating Acupuncture Into ERAS for Ambulatory Total Hip Replacement (THR) Surgery
At this time, no formal ERAS (enhanced recovery after surgery) protocol exists for THR that incorporates perioperative acupuncture.
- Conditions
- Acupuncture, Hip Surgery, Opioid Use
- Trial name
- NCT05384860
- Testing
- Auricular Trauma Protocol (ATP) Acupuncture, No Acupuncture Group
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- Hospital for Special Surgery, New York
Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip
CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
The purpose of this study is to analyze the efficacy and accuracy of real-time continuous glucose monitoring devices (rtCGM) in patients with Type 2 diabetes undergoing inpatient elective hip or knee surgery in the pre-, peri…
- Conditions
- Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT05666479
- Testing
- Dexcom G6 Pro Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3002
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as Monotherapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are not…
- Trial name
- NCT02336698
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg
- Where
- 32 sites in United States, Poland and 2 more
- Volunteers
- 18 people
- Sponsor
- Janssen Research & Development, LLC
Pain, Postoperative, Anesthesia, Conduction
Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery
The purpose of this study was to evaluate the analgesic efficacy of the nervus cutaneous femoral lateralis (NCFL) blockade on postoperative pain after total hip replacement surgery. The NCFL-block is a pure sensory block.
- Conditions
- Pain, Postoperative, Anesthesia, Conduction, Arthroplasty, Replacement, Hip
- Trial name
- NCT02289937
- Testing
- Ropivacaine, An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively
- Volunteers
- 100 people
- Sponsor
- Daniel Hägi-Pedersen
Osteoarthritis
Ergometer Cycling After Replacement of the Hip or Knee Joint
Despite the widespread use of hip and knee replacement surgery, there is a considerable lack of consensus regarding postoperative treatment and rehabilitation, mostly because of the lack of well-designed studies testing the…
- Trial name
- NCT00951990
- Testing
- Ergometer Cycling, No ergometer cycling
- Where
- 5 sites in Germany
- Volunteers
- 457 people
- Sponsor
- Verein zur Förderung der Rehabilitationsforschung in Schleswig-Holstein
Total Hip Replacement, Patient-Reported Outcomes
Patient Scores and Functional Tests After Hip Surgery
This study aims to explore how well patient self-assessments reflect their actual physical performance following hip replacement surgery.
- Trial name
- NCT07048041
- Testing
- Functional Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ordu University