Clinical trials: Hip and Knee Arthroplasties, open to volunteers
Pain Management, Arthroplasty
Effect of Preoperative Pain Education on Anxiety, Pain, and Analgesic Use in Total Knee and Hip Replacement Patients
This randomized controlled trial evaluates whether a standardized preoperative pain education session delivered by a nurse reduces postoperative pain intensity and surgical anxiety among adult elective orthopedic surgery patients…
- Conditions
- Pain Management, Arthroplasty, Knee Replacement, Hip Replacement
- Trial name
- Pain-Anxiety (NCT07362589)
- Testing
- Pain education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yeditepe University
Postoperative Outcomes, Postoperative Complications
The Effect of Perioperative Nutritional Care on Recovery After Knee and Hip Replacement Surgery
This prospective observational study will assess the impact of standardized perioperative nutritional care on postoperative outcomes in patients undergoing elective total hip (THA) or knee arthroplasty (TKA) at the First…
- Conditions
- Postoperative Outcomes, Postoperative Complications, Length of Hospital Stay
- Trial name
- NCT06989229
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Osteoarthritis, Arthroplasty
Heidelberg Registry for Hip and Knee Joint Implants and Revisions
The Endoprosthesis Registry Heidelberg (EPR-HD) is a clinical registry designed to systematically collect and analyze data from patients undergoing primary implantation or revision surgery of artificial hip and knee joints.
- Trial name
- EPR-HD (NCT06850818)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Heidelberg
Osteoarthritis, Knee, Osteoarthritis, Hip
Promoting Sleep to Alleviate Pain - Arthroplasty
PROSAP-A is a perioperative randomized, controlled trial with a 12-month follow-up period after total knee arthroplasty (TKA) or total hip arthroplasty (THA), aiming to investigate both acute and long-term postoperative effects…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Insomnia, Surgery
- Trial name
- PROSAP-A (NCT06145516)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I), Sleep education therapy (SET)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Uppsala University
Osteoarthritis (Knee / Hip), Sarcopenia
Preoperative Muscle Stiffness, Functional Reserve, and Postoperative Quality of Recovery in Lower Extremity Arthroplasty
In elderly patients undergoing arthroplasty surgery, postoperative recovery quality is closely related to preoperative physical reserve. Sarcopenia and reduced muscle quality can increase postoperative complications.
- Conditions
- Osteoarthritis (Knee / Hip), Sarcopenia, Postoperative Recovery
- Trial name
- PRE-QoR (NCT07879209)
- Testing
- Handgrip Strength (HGS) Measurement, Ultrasound Shear Wave Elastography (SWE)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Allergic Contact Dermatitis, Osteoarthritis, Hip
Rate of Allergic Contact Dermatitis and Cosmetic Outcomes
The patients from the Department of Orthopaedics Center for Joint Replacement will be asked to participate in the study. These patients will be randomized to one of three wound closure products, Sylke adhesive dressing, Exofin…
- Conditions
- Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT06957444
- Testing
- Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- West Virginia University
Anxiety, Osteoarthritis
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward…
- Trial name
- NCT07845695
- Testing
- Music via Headphones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Columbia University
Arthroplasty
Arthroplasty Cements Outcomes - A Post-market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all Teknimed Arthroplasty range of products: CEMFIX® and GENTAFIX® bone cements families and CEMSTOP® cement restrictor, and all…
- Trial name
- NCT06354543
- Testing
- Cemented joint arthroplasty
- Where
- 10 sites in France, Italy
- Volunteers
- 1,050 people
- Sponsor
- Teknimed
Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting
The Effect of White and Pink Noise in Patients Undergoing Total Hip and Knee Arthroplasty
This study aims to investigate the effects of preoperative white noise and pink noise interventions on sleep quality, anxiety, postoperative pain, nausea, and physiological parameters in patients undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Knee, Hip, Postoperative Nausea and Vomiting, Anxiety, Postoperative Pain After Arthroscopic Knee Surgery
- Trial name
- NCT07858058
- Testing
- White Noise Intervention, Pink Noise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people
- Sponsor
- Ataturk University
Knee Arthropathy, Hip Arthropathy
Routine Use of Negative Pressure Wound Therapy THR TKR RCT
Negative pressure wound therapy (NPWT) for post total joint arthroplasty incisions has demonstrated benefits in reducing wound complications.
- Conditions
- Knee Arthropathy, Hip Arthropathy, Negative Pressure Wound Therapy
- Trial name
- NCT06181097
- Testing
- negative pressure wound therapy, standard dressing
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- Chinese University of Hong Kong
Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
Periprosthetic Fracture Registry (PPFx)
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity…
- Trial name
- PPFx (NCT03378557)
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 600 people
- Sponsor
- AO Innovation Translation Center
Surgical, Anxiety
Virtual Reality Therapy to Improve Arthroplasty Outcomes
Virtual reality (VR) has recently emerged as a non-medication-based method to manage anxiety. The patient wears a VR headset and is offered an immersive environment with hypnotic components with sound and imagery in a 3D…
- Conditions
- Surgical, Anxiety, Pain Management, Joint (Knee or Hip Replacement)
- Trial name
- VROOM (NCT07872670)
- Testing
- Virtual Reality Headset, Blood Samples, Questionnaires
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Highland Research, Development and Innovation Organisation
Osteo Arthritis Knee and Hip
Total Hip Replacement: an Investigation of Robotic-assisted Versus conVentional Surgery and Patient-centred outcomEs
Hip replacement is highly effective for severe osteoarthritis, but some patients continue to experience symptoms or complications.
- Trial name
- THRIVE (NCT07907185)
- Testing
- MAKO Robotic System (Stryker, USA), Conventional Total Hip Arthroplasty
- Volunteers
- 90 people
- Sponsor
- Hamilton Health Sciences Corporation
Arthroplasty Complications
Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?
Venous thrombosis and pulmonary embolism are considered serious and potentially preventable complications of hip and knee replacement surgery.
- Trial name
- NCT06563531
- Testing
- Pharmacological thromboprophylaxis and elastic compression, Pharmacological thromboprophylaxis without elastic compression
- Where
- France
- Volunteers
- 1,274 people
- Sponsor
- Clinique Pasteur Lanroze
Hip Arthroplasty, Knee Arthroplasty
Anaesthesia for Hip and Knee Arthroplasty (SPIGA)
Beneficial and harmful effects of spinal versus general anaesthesia in patients undergoing hip and knee arthroplasty.
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, Spinal Anesthesia, General Anesthesia
- Trial name
- SPIGA (NCT07834242)
- Testing
- Spinal anaesthesia, General anaesthesia
- Volunteers
- 3,000 people
- Sponsor
- Zealand University Hospital
Frail Elderly, Arthroplasties Hip Replacement
Frailty in Hip or Knee Arthroplasty Patients.
The study aims to understand the existing differences between frail and non-frail subjects who underwent a rehabilitation path after receiving hip or knee arthroplasty surgery.
- Conditions
- Frail Elderly, Arthroplasties Hip Replacement, Arthroplasty Knee
- Trial name
- FRAKH (NCT07086716)
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Joel Pollet
Arthritis, Obesity & Overweight
GLP-1s in Hip and Knee Arthroplasty
The number of people living with hip and knee arthritis continues to grow. A large amount of these people are also overweight and diagnosed with obesity.
- Conditions
- Arthritis, Obesity & Overweight, GLP - 1
- Trial name
- NCT07755085
- Testing
- GLP-1 Receptor Agonists + Behavioral modification
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Venous Thromboembolism, Venous Thromboses
inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT
After hip or knee replacement all patients receive a standardized treatment with blood thinners, this medication is called thrombosis prophylaxis.
- Conditions
- Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- DISTINCT (NCT06581965)
- Testing
- Short duration prophylaxis, Higher intensity and longer duration prophylaxis, Control
- Where
- 13 sites in Netherlands
- Volunteers
- 10,078 people
- Sponsor
- Leiden University Medical Center
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic