Clinical trials: Hippocampal Sclerosis
Epilepsy, Epilepsy, Temporal Lobe
Early Surgical Intervention to Treat Epilepsy
The purpose of this trial is to compare the effectiveness of early surgical intervention for mesial temporal lobe epilepsy to continued treatment with antiepileptic drugs.
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Seizures
- Trial name
- ERSET (NCT00040326)
- Testing
- anteromesial temporal resection, antiepileptic drugs
- Where
- 12 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of California, Los Angeles
Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
The goal of this retrospective study is to evaluate the long-term clinical outcomes and complications associated with amygdalo-hippocampectomy using the surgical technique developed by Pr. Coubes (Montpellier, FRANCE).
- Conditions
- Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor, Cortical Dysplasia, Ganglioglioma
- Trial name
- NCT06915649
- Testing
- Amygdalo-Hippocampectomy
- Where
- France
- Volunteers
- 3,504 people
- Sponsor
- University Hospital, Montpellier
Epilepsy, Temporal Lobe
SEEG Guided RF-TC v.s. ATL for mTLE With HS
Mesial temporal lobe epilepsy (mTLE) is the most classical subtype of temporal lobe epilepsy, which is the indication of surgical intervention after evaluation.
- Trial name
- STARTS (NCT03941613)
- Testing
- SEEG guided RF-TC, Anterior temporal lobectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Mesial Temporal Lobe Epilepsy
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
The main goals of this clinical study are to learn if AMT-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (MTLE).
- Trial name
- GenTLE (NCT06063850)
- Testing
- AAV9-hSyn1-miGRIK2
- Where
- 18 sites in United States
- Volunteers
- 12 people
- Sponsor
- UniQure Biopharma B.V.
Epilepsy, Drug Resistant
Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Piriform cortex as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy…
- Trial name
- NCT07128563
- Testing
- piriform cortex-DBS
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Subiculum as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with…
- Trial name
- NCT06436547
- Testing
- Subiculum-DBS ON
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Multiple Sclerosis
Correlation Between Cognitive Functions and MRI in Multiple Sclerosis
The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.
- Trial name
- NCT00423111
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
MRI Hippocampal Microstructure and Episodic Memory in Early Multiple Sclerosis
Clinically isolated syndrome (CIS) can evolve into multiple sclerosis. In CIS patients, episodic memory is frequently impaired. Memory disorders could be preceded by microstructural abnormalities without visible atrophy in…
- Trial name
- Micro-MS (NCT03692975)
- Testing
- Clinical assessment, Neuropsychological evaluation, Psychological evaluation
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Patients With Cognitive Disturbances
Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease
Hippocampal Sclerosis (HS) leads to anterograde amnesia mimicking early Alzheimer's disease (AD) (so called HSA-nonAD). Recent studies showed that (a) the deficit of episodic memory as well as the level of hippocampal atrophy in…
- Trial name
- ShaTau7 (NCT02576821)
- Testing
- Neurological examinations, Neuropsychological examinations, Clinical examinations
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Epilepsy
Herpes Virus-6 and Epilepsy
This study will explore whether the human herpes virus-6 is associated with epileptic seizures. The virus may be involved in brain scarring, called mesial temporal sclerosis, which is seen in some epilepsy patients.
- Trial name
- NCT00085683
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Drug Resistant Epilepsy
Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy
Social cognition, which refers to the ability to interpret social information and behave accordingly in a social environment, is crucial in everyday life.
- Trial name
- SocrAlt (NCT05527093)
- Testing
- MRI 3T and MRI 7T
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Hippocampal Sclerosis
Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis
Epilepsy is a common neurological disease, manifested in the sudden abnormal discharge of neurons leading to short-term brain dysfunction, has become the neurology after headache the second most common disease.
- Trial name
- NCT04917939
- Testing
- RNA sequencing
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis, Epilepsy
High Selective Subiculum SEEG Guided RF-TC for mTLE-HS
The primary objective of this research is to study the efficacy and safety of Stereotactic EEG (SEEG) guided radio-frequency thermocoagulation (RF-TC) of Subiculum as adjunctive therapy for reducing the frequency of seizures in…
- Trial name
- NCT06558864
- Testing
- Subiculum RF-TC
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Dementia, Mild Cognitive Impairment
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
Widespread recognition of the current and projected impact of the dementia epidemic has spurred research into novel drug discovery efforts.
- Trial name
- SMArT-HS (NCT04120766)
- Testing
- Nicorandil
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gregory Jicha, MD, PhD