Clinical trials: Hippocampal-avoidance
Breast Cancer, Brain Metastasis
Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer
The incidence of brain metastases (BM) in metastatic breast cancer is increasing, due to the improvement in the control of systemic disease, and due to an improved detection through imagery.
- Trial name
- NCT01942980
- Testing
- Radiation therapy Brain metastasis in breast cancer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Paoli-Calmettes
SCLC,Extensive Stage, Brain Metastases
WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases
This study aims to evaluate the safety and efficacy of hippocampal-sparing WBRT combined with SRS as first-line treatment for SCLC patients with brain metastases.
- Trial name
- NCT06243003
- Testing
- HA-WBRT plus SBRT
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fudan University
Breast Cancer Metastatic, Brain Metastases
Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer
Based on evidence that radiation-induced damage to the hippocampus plays a considerable role in neurocognitive decline after cranial irradiation, hippocampal-sparing whole brain radiation therapy (HS-WBRT) has been proposed.
- Trial name
- NCT03002532
- Testing
- whole brain radiotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Brain Metastases
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial
This research study is studying two different types of radiation as treatment for brain metastases (tumors in the brain that spread from a cancer that originated elsewhere in the body)
- Trial name
- NCT03075072
- Testing
- Whole brain radiation, Stereotactic radiation (SRS)
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- Brigham and Women's Hospital
Small Cell Lung Cancer, Lung Cancer
Hippocampus Avoidance PCI vs PCI
Using Intensity Modulated radiotherapy it is possible to treat the entire brain to standard dosages of whole-brain radiation, while keeping the radiation dose to the hippocampus low.
- Trial name
- HA-PCI (NCT01780675)
- Testing
- Radiation Prophylactic Cranial Irradiation, Radiation Hippocampal Avoidance PCI
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Glioma, Pilocytic Astrocytoma
Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
Low-grade gliomas (LGGs) are the most common brain tumors in children, and a subset of these tumors are treated definitively with focal radiation therapy (RT).
- Conditions
- Glioma, Pilocytic Astrocytoma, Pilomyxoid Astrocytoma, Pleomorphic Xanthoastrocytoma
- Trial name
- NCT04065776
- Testing
- Hippocampal-avoidance proton therapy
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- St. Jude Children's Research Hospital
Metastatic Malignant Neoplasm to Brain
Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases
Brain metastases are the most common brain tumors in adults. It is estimated that around 10-30% of cancer patients would develop brain metastases during the course of their illness.
- Trial name
- NCT04801342
- Testing
- Conformal Whole Brain Radiotherapy with Unilateral Hippocampal Avoidance, Conformal Whole Brain Radiotherapy with Bilateral Hippocampal Avoidance, Memantine Hydrochloride
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Brain Metastases, Adult, Neurocognitive Function
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing…
- Conditions
- Brain Metastases, Adult, Neurocognitive Function, Cancer, Meningioma of Brain
- Trial name
- IG-SRS (NCT04343157)
- Testing
- Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jona Hattangadi-Gluth
Metastatic Malignant Neoplasm to Brain
Neurocognitive Outcome of Conformal WBRT w/wo Hippocampal Avoidance for Brain Metastases
Brain metastases are the most common brain tumors in adults. It is estimated that around 10-30% of cancer patients would develop brain metastases during the course of their illness.
- Trial name
- NCT02393131
- Testing
- Hippocampal avoidance WBRT, Conformal WBRT
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Brain Metastases
Elective Simultaneous Modulated Accelerated Brain Radiation Therapy for NSCLCs With Limited Brain Metastases
Brain metastases are the most common intracranial tumors in adults. Whole-brain radiation therapy (WBI) increases the median survival of patients with brain metastases up to 3-6 months, but WBI can lead to the decline of…
- Trial name
- SMART-Brain (NCT03414944)
- Testing
- SMART-Brain
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong Cancer Hospital and Institute
Lung Neoplasm, Brain Metastases
HA-WBRT-SIB for Brain Metastasis of Lung Cancer
Patients with lung cancer and brain metastases undergo HA-WBRT-SIB using image-guided radiotherapy, receiving a total dose of 30-36 Gy delivered in 18-20 fractions to the whole brain (CTV), while the dose to the GTV is boosted to…
- Conditions
- Lung Neoplasm, Brain Metastases, Simultaneous Integrated Boost, Hippocampal Avoidance
- Trial name
- NCT06289023
- Testing
- HA-WBRT-SIB
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Brain Metastases
HA-WBRT vs SRS in Patients With Multiple Brain Metastases
This study compares the effectiveness and safety of two radiation treatment techniques for patients with multiple brain metastases.
- Trial name
- HipSter (NCT04277403)
- Testing
- Hippocampal Avoiding Whole Brain Radiation Therapy with Simultaneous Integrated Boost, Single session or hypofractionated stereotactic radiosurgery
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University Innsbruck
Brain Metastasis, Radiation Therapy Complication
A Clinical Trial on Whole-brain Radiotherapy With Temozolomide Concurrent Chemotherapy or Avoidance of Hippocampus for Patients of Brain Metastases
The purpose of this study is to evaluate the effects on neurocognitive function of whole-brain radiotherapy (WBRT) with/without TMZ concurrent chemotherapy or avoidance of hippocampus for patients of brain metastases, as well as…
- Trial name
- NCT02832635
- Testing
- TMZ, WBRT with avoidance of hippocampus, WBRT without avoidance of hippocampus
- Where
- 10 sites in China
- Volunteers
- 256 people
- Sponsor
- Sun Yat-sen University
Cognitive/Functional Effects, Metastatic Cancer
Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. PURPOSE: This phase II trial is studying how well avoiding the hippocampus during whole-brain radiation therapy works in treating patients with brain…
- Conditions
- Cognitive/Functional Effects, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT01227954
- Testing
- intensity-modulated radiation therapy
- Where
- 63 sites in United States, Canada
- Volunteers
- 113 people
- Sponsor
- Radiation Therapy Oncology Group
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer
This phase II clinical trial studies how well craniospinal irradiation (CSI) with hippocampal avoidance, using proton therapy or volumetric modulated arc therapy (VMAT), works in treating patients with breast cancer or non-small…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges
- Trial name
- NCT06518057
- Testing
- Biospecimen Collection, Computed Tomography, Electronic Health Record Review
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Small-Cell Lung Cancer
Early Hippocampal Avoidance Prophylactic Cranial Irradiation in Patients With LD SCLC
The main objective of this trial is to assess NCF after early HA-PCI concomitant to the second cycle of CHT and to tRT for patients with LD SCLC.
- Trial name
- NCT02058056
- Testing
- Irradiation: HA-PCI
- Where
- 8 sites in Switzerland
- Volunteers
- 44 people
- Sponsor
- Swiss Cancer Institute
Intracranial Metastatic Disease From Any Solid Malignancy
Simulation-Free Hippocampal-Avoidance Whole Brain Radiotherapy Using Diagnostic MRI-Based and Cone Beam Computed Tomography-Guided On-Table Adaptive Planning in a Novel Ring Gantry Radiotherapy Device
Hippocampal-avoidance whole brain radiation therapy (HA-WBRT) limits radiation dose to the hippocampal-avoidance region while still delivering therapeutic doses of radiation to the whole brain.
- Trial name
- NCT05096286
- Testing
- Ethos Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Extensive Stage Small Cell Lung Carcinoma, Limited Stage Small Cell Lung Carcinoma
Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer
This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues…
- Trial name
- NCT02635009
- Testing
- Three-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- 281 sites in United States, Canada
- Volunteers
- 418 people
- Sponsor
- NRG Oncology
Brain Metastasis, Brain Metastases
Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study
For newly-diagnosed patients with brain metastasis, whole brain radiation therapy (WBRT) probably remains a common palliative management even for those with oligometastatic brain disease.
- Trial name
- NCT03223675
- Testing
- hippocampal-sparing WBRT
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site…
- Conditions
- Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain, Solid Neoplasm
- Trial name
- NCT02360215
- Testing
- Whole brain radiation therapy with hippocampal avoidance, Memantine, Whole brain radiation therapy
- Where
- 220 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- NRG Oncology