Clinical trials: Hirschsprung Disease
Pediatric Disorder, Hirschprung's Disease
Transanal Versus Laparoscopic-assisted Transanal Through in the Management of Hirschsprung's Disease
The goal of this clinical trial is to compare the surgical and functional outcomes of pure transanal endorectal pull-through (TAERPT) and laparoscopic-assistance endorectal pull-through (LAERPT) in pediatric patients presented…
- Trial name
- NCT06419998
- Testing
- Group A: Pure transanal endorectal pull-through (TAERPT), Group B: Laparoscopic-assistance endorectal pull-through (LAERPT)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Egyptian Biomedical Research Network
Hirschsprung's Disease
Effects of Butyrate Enemas on Postoperative Intestinal Motility Disorders in Hirschsprung's Disease
Hirschsprung's disease (HD) is a rare congenital disorder (1/5000) defined by the absence of ganglion cells in the submucosal and myenteric plexuses along a variable length of the digestive tract.
- Trial name
- Buty-Hirsch (NCT03660176)
- Testing
- Sodium Butyrate, routine management
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hirschsprungs Disease
Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease
Children with chronic constipation, suspected of having hirschsprungs disease, who are admitted for rectal biopsy will be included in the study.
- Trial name
- NCT02342457
- Testing
- Child suspected of Hirschsprung disease
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Congenital Central Hypoventilation Syndrome
International Congenital Central Hypoventilation Syndrome (CCHS) Registry and CCHS SHARE
The Center for Autonomic Medicine in Pediatrics (CAMP), in collaboration with leading CCHS clinicians, scientists, and patient advocacy groups around the world has built the first International CCHS (Congenital Central…
- Trial name
- NCT03088020
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Hirschsprung Disease, Enterocolitis
Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of…
- Trial name
- HAEC (NCT02193685)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Cedars-Sinai Medical Center
Necrotizing Enterocolitis, Intestinal Atresia
Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children Hospital
This prospective observational study aims to evaluate the pattern, clinical presentation, complications, and short-term outcomes of neonates admitted with gastrointestinal emergencies to the NICU at Assiut University Children…
- Conditions
- Necrotizing Enterocolitis, Intestinal Atresia, Malrotation, Hirschsprung Disease
- Trial name
- NCT07526636
- Volunteers
- 120 people
- Sponsor
- Assiut University
Gastrointestinal Neoplasia, Hirschsprung's Disease
Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy
To test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection.
- Conditions
- Gastrointestinal Neoplasia, Hirschsprung's Disease, Esophageal Obstruction, Gastroparesis
- Trial name
- NCT03626350
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Colostomy, Hirschsprung Disease - Pull Through
Bowel Preparation in Elective Pediatric Colorectal Surgery
Infections after elective intestinal surgery remain a significant burden for patients and for the health care system. The cost of treating a single surgical site infection is estimated at approximately $27,000.
- Conditions
- Colostomy, Hirschsprung Disease - Pull Through, Necrotizing Enterocolitis, Inflammatory Bowel Diseases
- Trial name
- NCT03593252
- Testing
- Senna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral
- Volunteers
- 81 people
- Sponsor
- McMaster University
Anorectal Malformations, Transition
Transition of Care for Patients With Hirschsprung Disease and Anorectal Malformations
Transition from paediatric to adult health care is crucial for preventing deterioration of chronic diseases. At present, transitional care (TC) is not established for patients with the Hirschsprung disease (H) and Anorectal…
- Conditions
- Anorectal Malformations, Transition, Quality of Life, Hirschsprung Disease
- Trial name
- NOHARM (NCT04106947)
- Testing
- Questionnaires
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Pathology
Different Clinicopathological Features of Non-Elderly Sigmoid Volvulus Patients
Sigmoid volvulus is frequently seen in male patients over 60 years old. In the sigmoid volvulus <60 age groups, the male/female ratio is close to each other.
- Trial name
- NCT04360525
- Testing
- Reasons
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Hirschsprung Disease
Full Thickness vs. Rectal Suction Biopsy in the Diagnosis of Hirschsprungs Disease
The objective of this prospective study is to compare the diagnostic accuracy of rectal suction biopsy (RSB) compared to full thickness rectal biopsy (FTB) in the diagnosis of Hirschsprungs Disease (HD) in children.
- Trial name
- BIOPSY (NCT05307419)
- Testing
- Rectal suction biopsy., Full-thickness rectal biopsy.
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Southern Denmark
Chronic Constipation, Hirschsprung's Disease
Endoscopic Mucosal Resection (EMR) for Diagnosis of Hirschsprung's Disease
The purpose of this study is to compare the diagnostic yield with endoscopic mucosal resection (EMR) in hirschsprung's disease versus that of standard rectal suction biopsy.
- Trial name
- EDGE (NCT00671684)
- Testing
- Endoscopic Mucosal Resection (EMR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Indications for Laparoscopic Thoracic and Abdominal Surgery in Children, Congenital or Acquired Surgical Conditions Requiring Minimally Invasive Surgery in Children
Clinical Trial on Safety and Efficacy of Thoracoabdominal Endoscopic Surgical System for Pediatric Surgery
This is a prospective, multi-center, single-arm, target-value clinical trial conducted to evaluate the safety and effectiveness of the Thoracic and Abdominal Endoscopic Surgery System (model WJ-SR01-200) in pediatric surgical…
- Conditions
- Indications for Laparoscopic Thoracic and Abdominal Surgery in Children, Congenital or Acquired Surgical Conditions Requiring Minimally Invasive Surgery in Children, Pyeloplasty, Ureteral Reimplantation
- Trial name
- NCT07530133
- Testing
- Thoracic and Abdominal Endoscopic Surgery System
- Where
- 3 sites in China
- Volunteers
- 64 people
- Sponsor
- Hangzhou Kangji Weijing Medical Robotics Co., Ltd.
Hirschsprung's Disease Associated Enterocolitis
Neuro-Immune Interactions in the Gut
Hirschsprung's disease (HD) is diagnosed shortly after birth and is characterized by the presence of megacolon. HD is caused when ganglion cells of the enteric nervous system (ENS) in the wall of the large intestine do not…
- Trial name
- NIG (NCT03617640)
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Hirschsprung Disease
Effects of Physiotherapy in Children With Hirschsprung's Disease
The aim of our study is to investigate the effects of physiotherapy in children with Hirschsprung's disease who have bowel symptoms after surgery.
- Trial name
- NCT07156981
- Testing
- Physiotherapy
- Volunteers
- 20 people
- Sponsor
- Ankara Yildirim Beyazıt University
Probiotics, Hirschsprung's Disease Associated Enterocolitis
A Trial on Probiotics in Preventing Hirschsprung's Disease Associated Entercolitis
Enterocolitis(EC) is the most common and serious postoperative complication of Hirschsprung's disease(HD) with high morbidity and mortality.
- Trial name
- NCT01934959
- Testing
- Bifico
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Constipation, Hirschsprung Disease
Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)
Patients undergoing routine rectal suction biopsy will undergo as part of the study an additional Endoscopic mucosal resection. The biopsy results will also be correlated with patient's clinical data including clinical history…
- Trial name
- EDGE (NCT01515501)
- Testing
- Endoscopic mucosal resection (EMR)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Complications of Treatment, Complication of Surgical Procedure
A Trial on Treatments of Hirschsprung Allied Disease
The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in children with Hirschsprung allied disease
- Conditions
- Complications of Treatment, Complication of Surgical Procedure, Megacolon, Not Hirschsprung
- Trial name
- NCT02212054
- Testing
- conservative, operative
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Hirschsprung Disease
Scintigraphic Defecography for Evaluation of Functional Outcome in an Adult Hirschsprung Population
This study aims to investigate long term outcomes of surgical intervention for Hirschsprung's disease and to explore the relation between scintigraphic defecography, type of surgery performed and symptoms as evaluated by a…
- Trial name
- NCT04957667
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Southern Denmark