Clinical trials: Histamine
Histamine, Exercise
Histamines and Central Hemodynamics
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with…
- Trial name
- NCT07285031
- Testing
- Diphenhydramine hydrochloride, Exercise Bout
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Histamine, Cowhage
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
In This experiment, the investigators would like to test following hypotheses: repetitive cutaneous administration of pruritogens will lead to a more robust and longer lasting itch sensation compared with a single application.
- Trial name
- NCT06154824
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine, Cowhage
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli.
- Trial name
- NCT06328543
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine, Cowhage
Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals
This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies…
- Trial name
- NCT06340438
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine, Cowhage
Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)
In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of…
- Trial name
- NCT06328530
- Testing
- Cowhage, Histamine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Exercise, Histamine
Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on…
- Trial name
- NCT05131555
- Testing
- H1 blockade: H1 receptor antagonist + exercise training, H2 Blockade: H2 receptor antagonist + exercise training
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Ghent
Histamine, Cowhage
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: To investigate similarity and differences between itch and pain by comparing the effect of sleep…
- Conditions
- Histamine, Cowhage, Sleep Deprivation
- Trial name
- NCT06081998
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine
The Role of Histamine in Muscle Protein Synthesis Following Resistance Training
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten…
- Trial name
- NCT06152497
- Testing
- H1 blockade: Telfast: 180mg Fexofenadine, Resistance training
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Ghent
Morphine, Histamine
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine
The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch.
- Conditions
- Morphine, Histamine, Cowhage, Isotonic Saline
- Trial name
- NCT04672382
- Testing
- Morphine
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Itch, Thermal Stimulation
A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch.
- Conditions
- Itch, Thermal Stimulation, Histamine, Cowhage
- Trial name
- NCT03576053
- Testing
- Lidocaine, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Histamine H1 Antagonists, Non-Sedating
To Assess Bioequivalence of Loratadine Oral Solution/Syrup Versus Claritin Peach Syrup
To assess the bioequivalence of Loratadine Oral Solution/Syrup 1mg/mL (GPLA Formula) versus Claritin Peach Syrup 1mg/mL (ANNA Formula)
- Trial name
- Bordeaux (NCT02593747)
- Testing
- Loratadine oral solution, Loratadine (Claritin peach syrup)
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bayer
Histamine Intolerance
A Provocation Study Using Biogenic Amines to Show the Efficacy of Oral Diamine Oxidase Supplementation
This study aims to define a provocation test for histamine intolerance (aka. biogenic amine intolerance syndrome) and test the capability of an oral enzyme supplementation to ameliorate this condition.
- Trial name
- NCT02418221
- Testing
- Drawing blood, measuring BP & pulse
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- IPSC AG
Histamine Induced Itch
A Study To Investigate The Effect of JNJ-39758979 on Histamine Induced Itch in Healthy Male Volunteers
The purpose of this study is to investigate the effect of JNJ-39758979 compared to placebo on histamine induced itch in healthy male volunteers.
- Trial name
- NCT01068223
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Histamine Responsive Allergy Patients
The Evaluation of Bepreve on the Measurement of Wheal and Flare Response From Histamine Skin Prick Testing
To evaluate the effect of BEPREVE compared to a REFRESH Tears Lubricant eye drop on the measurement of the wheal and flare from histamine skin prick testing.
- Trial name
- NCT01128556
- Testing
- Bepreve, Refresh Tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Texas Institute for Clinical Trials