Clinical trials: Histamine
Healthy Subjects
Clinical Study on Histamine H3 Receptor Occupancy of TS-091 by PET Examination in Healthy Adult Subjects
To evaluate the following items by PET examination in Japanese heathy adult male subjects who received single oral administration of TS-091 in an unblinded manner. 1.
- Trial name
- NCT04631276
- Testing
- TS-091
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Schizophrenia
Study to Evaluate the Efficacy and Safety of GSK239512 in Schizophrenia
This study aims to evaluate the cognitive enhancing effects and tolerability of GSK239512 compared to placebo in patients with schizophrenia
- Trial name
- NCT01009060
- Testing
- GSK239512
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- GlaxoSmithKline
Histamine, Cowhage
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli.
- Trial name
- NCT06328543
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Prehypertension (elevated Blood Pressure) or Hypertension
Effect of Aerobic Exercise with Blood Flow Restriction on Post-exercise Hypotension in Young Adults: the Role of Histamine Receptors
It was hypothesized that aerobic exercise with blood flow restriction (BFR) induced post exercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors.
- Trial name
- NCT06629337
- Testing
- H1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Obesity, Overweight
Effects of Betahistine Hydrochloride in Overweight Women
This study will evaluate the effects of a drug called betahistine on appetite and food intake in overweight women. Betahistine has been used for many years to treat vertigo (dizziness).
- Conditions
- Obesity, Overweight, Overnutrition
- Trial name
- NCT00459992
- Testing
- Betahistine Hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Exercise, Histamine
Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on…
- Trial name
- NCT05131555
- Testing
- H1 blockade: H1 receptor antagonist + exercise training, H2 Blockade: H2 receptor antagonist + exercise training
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Ghent
Irritable Bowel Syndrome (IBS)
Peripheral Histamine 1 Receptor Blockade in IBS: Multicenter Trial
Purpose: To evaluate the efficiency of Irritable Bowel Syndrome (IBS) patients treatment with the H1-receptor antagonist ebastine. Design: Double blind randomized placebo controlled trial.
- Trial name
- NCT01908465
- Testing
- Ebastine
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 200 people
- Sponsor
- KU Leuven
Bone Pain, Breast Carcinoma Metastatic in the Bone
Histamine and Bone Pain Association in Participants With Breast Cancer Metastatic in the Bone
This trial studies histamine and bone pain association in participants with breast cancer that has spread to the bone. Studying histamine levels in samples of blood from participants with breast cancer in the laboratory may help…
- Trial name
- NCT03529565
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Arterial Hypertension, Right Heart Failure
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension
This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension.
- Trial name
- REHAB-PH (NCT03554291)
- Testing
- Famotidine 20 MG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Zollinger Ellison Syndrome
Treatment of Zollinger-Ellison Syndrome
In patients with Zollinger-Ellison Syndrome the level of gastric acid is elevated. This increased level of gastric acid is what causes the symptoms of the disease.
- Trial name
- NCT00001241
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia
Histamine H2 Antagonism as Adjuvant Therapy in Treatment Resistant Schizophrenia
The purpose of the study is to investigate whether blockade of the histamine H2 receptors in the brain will have any beneficial effect on the symptoms of subjects with schizophrenia.
- Trial name
- NCT00565175
- Testing
- famotidine
- Where
- 5 sites in Finland
- Volunteers
- 30 people
- Sponsor
- Jesper Ekelund
Diet Modification, Chronic Urticaria
Dietary Treatment for Chronic Urticaria
Histamine is a biologically active component that can be found in many foods and beverages. Intake of excessive histamine from foods or beverages, can trigger symptoms including urticaria.
- Trial name
- DTCU (NCT02047136)
- Testing
- Treatment group (on low histamine diet), Well-balanced diet
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hong Kong Sanatorium & Hospital
Bone Pain in Stage I - III Breast Cancer
NOLAN: Naproxen or Loratadine and Neulasta
The primary objective of the study is to estimate the difference in bone pain between breast cancer patients receiving chemotherapy and pegfilgrastim and either no prophylactic intervention, prophylactic naproxen, or prophylactic…
- Trial name
- NOLAN (NCT01712009)
- Testing
- Naproxen, Loratadine, Pegfilgrastim
- Where
- 83 sites in United States
- Volunteers
- 600 people
- Sponsor
- Amgen
Gastroesophageal Reflux Disease (GERD), Community-acquired Pneumonia
Proton Pump Inhibitors and Risk of Community-acquired Pneumonia
The purpose of the study is to determine whether proton pump inhibitors (PPIs), a medication used to treat gastric conditions, increase the risk of hospitalization for community-acquired pneumonia (HCAP).
- Trial name
- NCT02555852
- Testing
- esomeprazole, omeprazole, pantoprazole
- Where
- Canada
- Volunteers
- 4,238,504 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Histamine Intolerance
Kinetic Study Of Supplementation With The Enzyme Diamine Oxidase In Patients With Histamine Intolerance
The present study was conducted to assess the safety and tolerability of five ascending doses of plant-based DAO enzyme supplement in subjects with symptoms of histamine intolerance.
- Trial name
- HCB/2023/0345 (NCT07006558)
- Testing
- Diamino Oxidase
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- AB Biotek
Angioedema
Determination of Specific Biomarkers of Angioneurotic Crisis
Diagnosis of angioedema (AE) is difficult especially in emergency room. Two forms should be evoked: histaminic AE (allergic or not, which represent 95% of cases) and bradykinic AE (hereditary or acquired deficiency, with or…
- Trial name
- BIOBRAD (NCT02833675)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Migraine, Sinusitis
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers
The primary objective of this study is to evaluate histamine, CGRP and VIP levels in saliva as biological markers for activation of trigeminal and parasympathetic nerve fibers in various clinical presentations of primary…
- Trial name
- NCT00208065
- Testing
- almotriptan or pseudoephedrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinvest
Osteoarthritis of the Knee
Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation
The study will evaluate Apitox, pure honeybee venom as a treatment for pain and inflammation of osteoarthritis of the knee.
- Trial name
- HBV (NCT00949754)
- Testing
- honeybee venom (Apitoxin (Korea) Apitox (USA))
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Apimeds, Inc.
Melanoma (Skin), Metastatic Cancer
Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Stage IV Melanoma Metastatic to the Liver
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill tumor cells. Histamine dihydrochloride may help interleukin-2 kill more tumor cells by making tumor cells more sensitive to the drug.
- Trial name
- NCT00039234
- Testing
- aldesleukin, histamine dihydrochloride
- Where
- 19 sites in United States, Canada and 2 more
- Sponsor
- Maxim Pharmaceuticals
Drug Interaction
Impact of a Histamine H2 Receptor Antagonist (H2RA) on the Pharmacokinetics (PK) of Telaglenastat in Healthy Subjects
This study is designed to formally evaluate the impact of famotidine, an H2R antagonist, on the pharmacokinetics of telaglenastat.
- Trial name
- NCT04540965
- Testing
- Telaglenastat, Famotidine
- Where
- Australia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Calithera Biosciences, Inc