Clinical trials: Homeostasis
Homeostasis, Metabolism and Nutrition Disorder
Energy Metabolism Profiles Over Weight-loss and Eating Responses
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese.
- Conditions
- Homeostasis, Metabolism and Nutrition Disorder, Healthy, Obesity
- Trial name
- NCT05785221
- Testing
- General lifestyle and nutritional education, Personalized nutritional and lifestyle weight reduction intervention
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Vaginal Delivery, Cesarian Section
Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis
Modes of delivery impact maternal oxidative stress biomarkers and dynamic thiol disulphide homeostasis
- Conditions
- Vaginal Delivery, Cesarian Section, Oxidative Stress
- Trial name
- NCT06826508
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Mardin Artuklu University
Vitamin D Deficiency
Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children
The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and if it may have functional consequences on vitamin D activity.
- Trial name
- VitaD (NCT01050387)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder
Effects of Ghrelin Administration on Dopamine and Effort
Ghrelin is a stomach-derived hormone and the only known circulating peptide that stimulates appetite. Animal studies have conclusively shown that ghrelin increases dopaminergic neurotransmission and, thereby, enhances effort.
- Trial name
- NCT05318924
- Testing
- Ghrelin
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Healthy, Metabolic Syndrome
Study of Metabolic Homeostasis in Chinese
In this open-label, acute intervention study, we will recruit 120 sex-matched participants aged 20-70 years (100 normal or overweight/obese subjects and 20 Mets subjects).
- Trial name
- NCT04173728
- Testing
- Standard mixed macronutrients tolerance test
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Glucose Tolerance, Lipid Homeostasis
Herbal Preparation and Glucose Homeostasis
Rationale: The incidence of obesity and type 2 diabetes (T2D) is increasing rapidly and accounts for a considerable part of health care costs.
- Conditions
- Glucose Tolerance, Lipid Homeostasis, Vascular Function, Inflammation
- Trial name
- Herbie (NCT02065271)
- Testing
- herbal supplement
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Mitochondrial Diseases, Obesity
Muscle OXPHOS and Nutrient Homeostasis
Investigators are recruiting adults (men and women, ages 18 to 65 years, inclusive) with a confirmed genetic diagnosis of mitochondrial disease.
- Trial name
- NCT02920671
- Testing
- Tracer-enhanced oral glucose tolerance test (OGTT*), Muscle MRI, Dual energy x-ray absorptiometry (DXA)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Obesity, Metabolic Disease
The Role of Secretin on the Energy Homeostasis
As of last year, new insight into the function of secretin was brought about as rodent studies showed secretin to possess potential body weight-regulating effects.
- Conditions
- Obesity, Metabolic Disease, Diabetes, Adiposity
- Trial name
- THE-ROSE (NCT04613700)
- Testing
- Secretin
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve head (ONH) circulation has been shown in animals and…
- Trial name
- NCT00914992
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Healthy
Factors That Determine the Responses to Food Ingestion: Protein Load
Aim: to determine to what extent meal composition influences postprandial sensations. Experimental design: randomized cross-ower study comparing the responses to a high protein (47.3% protein, 39.4% carbohydrates, 13.3% lipids)…
- Trial name
- NCT06139237
- Testing
- High-protein supplement, Balanced supplement
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Glucose Tolerance
Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis
This clinical trial is designed to study the effects of rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers.
- Trial name
- NCT00985270
- Testing
- Rifampicin
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Tourniquets
Ischemic Preconditioning and Thiol-disulfide Balance
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases.
- Trial name
- NCT05082207
- Testing
- Remote Ischemic Preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Intraoperative Cerebral Autoregulation Monitoring
AUTOREGULATE- NONCARDIAC-COTRENDING
This study is to prospectively assess the feasibility and clinical implications of intraoperative real-time cAR monitoring using the Medtronic Cotrending algorithm.
- Trial name
- NCT07630129
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 256 people
- Sponsor
- University Hospital, Basel, Switzerland
Insulin Sensitivity, Type2 Diabetes
Dairy Products, Diabetes and Genetics
This study will investigate the in-depth the benefits of dairy consumption on glucose metabolism in patients at risk of type 2 diabetes using novel genomics methodology.To do so, 33 individuals at risk of type 2 diabetes will be…
- Trial name
- PRODIGE (NCT02961179)
- Testing
- Increased dairy product, Dietary counselling
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- CHU de Quebec-Universite Laval
Effect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and Strenght
Effects of Chronic Leucine Supplemetion on Glucose Homeostasis, Body Compositin, Muscle Mass and Strength of Healthy and Young Subjects
This study aims to evaluate the effects of chronic leucine supplemetion on glucose homeostasis, body compositin, muscle mass and strength of healthy and young subjects
- Trial name
- NCT01496768
- Testing
- Leucine, Alanine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Biological Response to Meal Ingestion: Gender Differences
Aim: to determine the effect of gender on the sensory and metabolomic responses to a standard probe meal. Participants (12 men and 12 women) will be instructed to eat a standard dinner the day before, to consume a standard…
- Trial name
- NCT03758482
- Testing
- Probe meal
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Health Adult Subjects
The Role of Incorporating Acacia Gum in Foods on Glucose Homeostasis in Healthy Humans
Abnormal postprandial blood glucose (PPG) is considered as a strong predictor for developing metabolic diseases worldwide. Nowadays, little understanding is available on how a carbohydrate-rich food matrix and the starch…
- Trial name
- AcaciaGlu (NCT07416643)
- Testing
- incorporating acacia gum flour into commonly consume foods
- Where
- Saudi Arabia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Lung Diseases, Total Intravenous Anesthesia
Comparison of iGel and THRIVE on Bronchoscopic Interventions
THRIVE and iGEL were applied for maintain oxygenation in bronchoscopic interventions which could not performed with an endotracheal tube.
- Conditions
- Lung Diseases, Total Intravenous Anesthesia, Tracheal Diseases
- Trial name
- NCT05046223
- Testing
- The responses to bronchoscopic insertion for bronchoscopic interventions such asTBNA, Cryotherapy, etc., postoperative recovery
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital