Clinical trials: Hook Worm
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Disease, Hookworm Infection
Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children
Double blind, randomized, controlled, dose-escalation Phase 1 clinical trial in hookworm-exposed children aged 6 to 10 years living in the area of Lambaréné, Gabon.
- Trial name
- NCT02839161
- Testing
- Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine
- Where
- Gabon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Necator Americanus Infection
Immune Responses in the Skin After Hookworm Infection
Five healthy volunteers will be repeatedly exposed to L3 Necator americanus larvae after which two skin biopsies will be taken. Three of the volunteers will be treated two weeks after each infection after which the study will end…
- Trial name
- HiBiSki (NCT06478498)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Celiac Disease
Hookworm Therapy for Coeliac Disease
This trial is a Phase 1b multicentre, multinational, randomized, double-blind with single-blind arm and open label extension phase, placebo controlled, clinical trial evaluating the safety and predictability of an escalating…
- Trial name
- NainCeD-3 (NCT02754609)
- Testing
- Gluten micro-challenge, Inadvertent gluten challenge, Moderate gluten challenge
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- James Cook University, Queensland, Australia
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Infections
Education Intervention to Reduce Helminth Infections and Absenteeism in Grade 5 School-children
To efficiently control soil-transmitted helminths (Ascaris, Trichuris, and hookworm), WHO, PAHO, and others recommend the inclusion of an education strategy in school-based deworming programs.
- Trial name
- NCT01085799
- Testing
- Health Education Intervention
- Where
- Peru
- Volunteers
- 1,101 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Soil-Transmitted Helminths
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
An open-label, randomized by school, two-arm pragmatic trial, will be conducted involving two study sites in Sub-Saharan-Africa (SSA), Ghana and Kenya, to evaluate safety and effectiveness of the newly developed fixed dose…
- Trial name
- NCT06282315
- Testing
- Pre-screening Phase, Screenig Phase, Randomization
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Intestinal Helminthiasis, Ascariasis
Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children
Many school children in Kenya are infected with plasmodia and helminth species and are at risk of coinfection. It has been suggested that the immune response evoked by helminth infections may modify immune responses to plasmodia…
- Conditions
- Intestinal Helminthiasis, Ascariasis, Hookworm, Malaria
- Trial name
- NCT01658774
- Testing
- Albendazole, Vitamin C
- Where
- Kenya
- Volunteers
- 2,377 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hookworm Infections
Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm
To compare the efficacy and safety of emodepside to that of albendazole (Zentel®) in participants aged 12-60, inclusive, infected with hookworm.
- Trial name
- NCT05538767
- Testing
- Emodepside, Albendazole 400mg
- Where
- Tanzania
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Diarrhoeal Disease, Hookworm Infection
Evaluating Impact of Improved Floors on Health
The goal of this intervention study is to learn about the impact of household flooring on health in rural Kenya, and test whether providing an improved (cement stabilised, washable) floor improves the health of children and their…
- Conditions
- Diarrhoeal Disease, Hookworm Infection, Ascaris Lumbricoides Infection, Trichuris Infection
- Trial name
- SABABU (NCT05914363)
- Testing
- Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming
- Where
- Kenya
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hookworm
Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar
Small association studies have hypothesised that shoes protect against hookworm infection. The purpose of this pragmatic study was determine, under field conditions, whether school-age children on Pemba Island, Zanzibar, would…
- Trial name
- SKIP (NCT01869127)
- Testing
- Shoes
- Where
- Tanzania
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- Bird, Christopher
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Hookworm Infection
Phase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian Adults
Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. Vaccination with recombinant ASP-2 has protected dogs and hamsters from infection in challenge studies.
- Trial name
- NCT00473967
- Testing
- Na-ASP-2 Hookworm Vaccine
- Where
- Brazil
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Hookworm Infection
Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil
Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset…
- Trial name
- NCT00939198
- Testing
- Na-ASP-2 Skin Test Reagent
- Where
- Brazil
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Hookworm Infection, Allergy
Development of a Skin Test for the Na-ASP-2 Hookworm Antigen
Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset…
- Trial name
- NCT00603889
- Testing
- Na-ASP-2 Skin Test Reagent
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Trichuris Trichiura; Infection, Hookworm Infections
Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm
The rationale of the study is to provide evidence on the efficacy and safety of Emodepside in adults infected with Trichuris trichiura and hookworm.
- Trial name
- EMODEP_PEMBA (NCT05017194)
- Testing
- Emodepside
- Where
- Tanzania
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Ascariasis, Trichuriasis
Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections
The aim of this study is to compare the efficacy and impact on growth of two drug treatments against intestinal worms in schoolchildren from a rural area of Guatemala.
- Conditions
- Ascariasis, Trichuriasis, Hookworm Infection, Strongyloidiasis
- Trial name
- NCT00207753
- Testing
- albendazole vs. combined albendazole/ivermectin treatment
- Where
- Guatemala
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Testing, Performance
Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Malaria, schistosomiasis and ancylostomiasis are three parasitic diseases which affect hundreds of millions of people and are an important cause of global mortality and morbidity.
- Conditions
- Testing, Performance, Specificity, Sensitivity
- Trial name
- INSPiRED-WP3 (NCT04505046)
- Where
- Gabon
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults
Na-GST-1 and Na-APR-1 are proteins expressed during the adult stage of the Necator americanus hookworm life cycle that are thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02126462
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine
- Where
- Gabon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection
Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection
The primary objective of this clinical trial is to determine the safety and tolerability of the Na-ASP-2 Hookworm Vaccine in healthy subjects following the administration of 3 intramuscular (IM) injections of the vaccine over 16…
- Trial name
- NCT00120081
- Testing
- Na-ASP-2/Alhydrogel Hookworm Vaccine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine