Clinical trials: Hopefulness
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Psychotic Disorders
HCT Effect Among Patients With Psychotic Disorders
Horticulture therapy has been found to have positive effects on individuals with psychotic disorders, promoting social interaction, reducing social isolation, and improving cognitive function.
- Trial name
- HCT (NCT06077279)
- Testing
- Horticultural Therapy Program
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Gynecologic Cancer
The HOPE Trial and the SMART Study
This research study is evaluating a new smartphone application named the "Helping Our Patients Excel (HOPE)" app with a Fitbit device. The SMART Study is a sub-study of the HOPE Trial.
- Trial name
- NCT03022032
- Testing
- Fitbit Zip, HOPE App, Standard of Care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Dana-Farber Cancer Institute
GASTROINTESTINAL NEOPLASMS
Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique
The goal of this observational study intends to explore the evolution trend and related factors of postoperative reflux of esophageal cancer based on PEPTEST detection, in order to identify postoperative reflux The main question…
- Trial name
- NCT06509022
- Testing
- PEPTEST test
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Heart Failure
The His Optimised Pacing Evaluated for Heart Failure Trial (HOPE-HF).
This is a multi-centre, prospective randomised double-blinded cross over study, recruiting a sub-population of patients with heart failure.
- Trial name
- HOPE-HF (NCT02671903)
- Testing
- Pacemaker: AV optimised, His pacing.
- Where
- 15 sites in United Kingdom
- Volunteers
- 198 people
- Sponsor
- Imperial College London
Pregnant
Project HOPE 1000: Health Outcomes Pregnancy Exposures
The purpose of this study is to collect biological samples from pregnant women and their babies and to collect data on long-term health, school outcomes, and the use of state and county services.
- Trial name
- NCT04417283
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Pregnancy Complicated by Low Implantation
Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept.
- Trial name
- ILRIFRM (NCT01679561)
- Testing
- intralipid
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Cardiovascular Diseases
HOPE-CVD-Virtual: A Virtual Trial to Evaluate the Primary Prevention of CVD
This 4-arm (1:1:1:1) single-blind randomized controlled trial. Arm 1 will communicate risk and encourage behavioral change that mirrors the standard pathway for health screening in Singapore.
- Trial name
- NCT05827861
- Testing
- HeartAge, HOPE-CVD Mobile App, Genetic Risk Score
- Where
- Singapore
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
ARDS
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration
This trial evaluates efficacy and safety of inhaled molgramostim (rhGM-CSF) in 45 patients with pneumonia associated acute respiratory distress syndrome (ARDS).
- Trial name
- GI-HOPE (NCT02595060)
- Testing
- inhaled molgramostim (rhGM-CSF)
- Where
- 7 sites in Germany
- Volunteers
- 45 people
- Sponsor
- University of Giessen
Hematopoietic and Lymphoid System Neoplasm, Hereditary Malignant Neoplasm
Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study
This clinical trial tests whether provider-mediated communication of genetic testing results to at-risk relatives of cancer patients can help improve genetic counseling and testing rates.
- Conditions
- Hematopoietic and Lymphoid System Neoplasm, Hereditary Malignant Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05772130
- Testing
- Best Practice, Electronic Health Record Review, Personal Contact
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Female Infertility Due to Diminished Ovarian Reserve
Microflare Protocol in Poor Responders
The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders
- Trial name
- NCT02185326
- Testing
- Growth hormone (Norditropin, Novo nordisk)
- Where
- Egypt
- Volunteers
- 145 people
- Sponsor
- Woman's Health University Hospital, Egypt
Anxiety, Stress
A New Mindfulness Intervention Called Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer
It is hypothesised to find that the new mindfulness intervention of Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer is an effective therapeutic intervention to be applied in breast cancer population.
- Conditions
- Anxiety, Stress, Self Efficacy, Depression
- Trial name
- NCT03985267
- Testing
- Mindfulness based Swinging Effect Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- University of Barcelona
Grief
Adolescent Suicide Loss Survivors Grief Intervention Group
This study will provide evidence-based recommendations for designing interventions tailored to adolescents dealing with suicide loss.
- Trial name
- NCT07151092
- Testing
- Adolescent Grief Group
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Elderly, Nursing Homes
Effects of Positive Psychology on Hope, Gratitude, and Well-Being
This randomized controlled study aims to evaluate the effects of an eight-week, group-based positive psychology program on hope, gratitude, and mental well-being among adults aged 65 years and older living in nursing homes in…
- Conditions
- Elderly, Nursing Homes, Positive Psychology
- Trial name
- NCT07895680
- Testing
- Positive Psychology Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Homelessness, Opioid Education and Naloxone Distribution (OEND)
Homeless Overdose Prevention- Expansion
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in…
- Conditions
- Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
- Trial name
- HOPE (NCT07716202)
- Testing
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- VA Office of Research and Development
Bipolar Affective Disorder
Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy
This study will examine: 1) The impact of psycho education group therapy sessions relating to beliefs/myths associated with bipolar affective disorder (BAD) on the emotional wellbeing, clinical course and cognition of individuals…
- Trial name
- BAD (NCT00474357)
- Testing
- Brief Structured Psychoeducation Group Therapy
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Lev-Hasharon Mental Healtlh Center
Advanced Cancer
Survival Expectations and Hope Among Cancer Patients at End-of-Life
Literature shows that less than half of advanced cancer patients accurately understand their prognosis, with most being overly optimistic.
- Trial name
- SHAPE (NCT03325218)
- Where
- 2 sites in Singapore
- Volunteers
- 214 people
- Sponsor
- Duke-NUS Graduate Medical School
Acute Ischemic Stroke
Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke
The HOPE-MeVO study aims to evaluate the efficacy and safety of intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic stroke due to medium vessel occlusion presenting 4.5 to 24 hours after stroke…
- Trial name
- HOPE-MeVO (NCT07776873)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), Standard medical treatment (SMT)
- Where
- China
- Volunteers
- 616 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Healthy
A Study of the Effects of a One-session Mindfulness of the Breath Meditation Practice on State Hope and State Gratitude in the General Population
This study aims to examine whether a brief mindfulness of the breath meditation practice is more helpful than listening to an audio recording in relation to improving hope and gratitude in the general population.
- Trial name
- NCT04099758
- Testing
- Mindfulness of the breath meditation, Audio-recording control
- Where
- United Kingdom
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus