Clinical trials: Hormonal Contraception
Abortion
Trial of Immediate Versus Delayed Initiation of Transdermal Hormonal Contraception After Therapeutic Abortion
This is a randomized, controlled trial investigating whether immediate versus standard, "Sunday Start", initiation of transdermal hormonal contraception (the patch) in post-abortion subjects can improve compliance and the…
- Trial name
- NCT00235547
- Testing
- timing of initiation of transdermal patch after an abortion
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contraception
An Open-label Study to Evaluate Contraceptive Efficacy and Safety of the Transdermal Contraceptive System of Norelgestromine and Ethinyl Estradiol
The purpose of this study is to evaluate the contraceptive efficacy, safety, cycle control, compliance, and subject satisfaction of the transdermal contraceptive system, norelgestromine and ethinyl estradiol (NLGM / EE).
- Trial name
- NCT00307632
- Testing
- Norelgestromine (NLGM)/ethinyl estradiol (EE)
- Where
- 12 sites in Brazil, Mexico
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag Farmaceutica Ltda.
Female Contraception
Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small.
- Trial name
- WOMEN&More (NCT06394999)
- Testing
- Mifepristone 50 mg
- Where
- 14 sites in Netherlands
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pharmacokinetics
The Pharmacokinetics of 12 Week Continuous Patch Use
Investigators propose a descriptive pharmacokinetic study of the serum hormone levels of estrogen and progesterone with extended use (12 weeks) of the contraceptive patch.
- Trial name
- NCT02585999
- Testing
- Xulane Contraceptive Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Contraception
YAZ, Oral Contraceptive Registration in China
The purpose of this study is to evaluate the effectiveness in terms of prevention of pregnancy and safety of the oral contraceptive YAZ in healthy Chinese women.
- Trial name
- NCT00819312
- Testing
- YAZ (SH T00186, BAY86-5300)
- Where
- 17 sites in China, Hong Kong
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- Bayer
Hormonal Contraception
Stress Reactivity and Hormonal Contraception
For almost 60 years, millions of women globally have relied on oral contraceptive (OC) pills for pregnancy prevention and addressing menstrual irregularities.
- Trial name
- NCT06223126
- Testing
- Combined oral contraception, Discontinuation of a combined oral contraception
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Contraception
A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Mercilon.
The purpose of the study was to compare the contraceptive efficacy and safety of the transdermal patch to Mercilon.
- Trial name
- NCT00236782
- Testing
- norelgestromin + ethinyl estradiol; mercilon
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Contraception
Contraceptive Efficacy Study of Ovaprene
This will be a multi-center, single arm, open-label study of Ovaprene, a non-hormonal intravaginal ring, to investigate the contraceptive effectiveness, safety and acceptability of Ovaprene.
- Trial name
- NCT06127199
- Testing
- Ovaprene
- Where
- 27 sites in United States
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.
Contraception, Female Contraception
A Study to Evaluate the Exposure of Norelgestromin and Ethinyl Estradiol From Commercial Lots of EVRA (a Transdermal Contraceptive Patch Manufactured by LOHMANN Therapie-Systeme) and CILEST (an Oral Contraceptive)
The objective of this study is to estimate exposure to the hormones norelgestromin, norgestrel, and ethinyl estradiol in healthy female volunteers across multiple commercial lots of EVRA® (a transdermal contraceptive patch…
- Trial name
- NCT00258063
- Testing
- EVRA® transdermal contraceptive patch containing 6 mg of norelgestromin and 0.60 mg of ethinyl estradiol (versus CILEST® tablets).
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Substrate Utilization
Substrate Utilization and Hormonal Status in Women
Women sexual hormones (i.e. estrogen) are involved in the regulation of substrate utilization and storage. Being under oral contraception (OC) may conduct to metabolic and hormonal modifications, but results are confused…
- Trial name
- NCT01095614
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Contraception
A Study to Compare 3 Doses of a Hormonal Intra-uterine Device Containing Levonorgestrel and Indomethacin With a Hormonal Intra-uterine Device Containing Only Levonorgestrel to Assess the Effect and Safety of the Combined Components
This study is the first study investigating the combined intrauterine administration of LNG (levonorgestrel) and IND (indomethacin). It is a combined proof-of-concept (PoC) and dose finding (DF) study in pre-menopausal women.
- Trial name
- INDessa (NCT03562624)
- Testing
- BAY98-7443, Levonogestrel (Skyla, BAY86-5028)
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Bayer
Contraception, Female Contraception
A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control
The purpose of the study is to use data from a health care information database to assess the risk of venous thromboembolism (blood clots), myocardial infarction (heart attacks), and stroke among women using a transdermal…
- Trial name
- NCT00377988
- Testing
- Transdermal Contraceptive System, Norgestimate-containing oral contraceptives with EE
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Contraception, Bone Density
Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception
To evaluate and compare Bone Mineral Density (BMD) in adolescent Depo-Provera Contraceptive Injection (DP150CI) users during depo medroxyprogesterone acetate (DMPA) therapy and following discontinuation of DMPA.
- Trial name
- NCT00139685
- Testing
- Depo-Provera Contraceptive Injection - DP150CI
- Where
- 12 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Pfizer
Contraception
Impact of Combined Hormonal Contraceptives on UPA
The purpose of this research study is to determine if taking a birth control pill effects how well an emergency contraceptive pill called Ulipristal acetate (UPA) works.
- Trial name
- NCT02577601
- Testing
- Ulipristal Acetate, Levonorgestrel (LNG)/Ethinyl estradiol birth control pill
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chlamydia Infection, Neisseriaceae Infection
Hormonal Contraception and Risk of Chlamydia and Gonorrhea
There are biological reasons to suspect that hormones may affect the risk of a woman becoming infected with a sexually transmitted disease.
- Trial name
- NCT00091728
- Testing
- Depo Medroxyprogesterone acetate, Combined oral contraceptives
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pregnancy Prevention
Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven Days
This clinical trial determines if an oral medication taken within 2 days of anticipated ovulation will delay ovulation by 7 days.
- Trial name
- OVULATION (NCT05695352)
- Testing
- Levonorgestrel 1.5mg, Meloxicam 15 mg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- InnovaGyn, Inc.
Contraception
The Direct Access Study: Access to Hormonal Birth Control Through Community Pharmacies
Hormonal birth control methods include birth control pills, patches, and vaginal rings; they are normally available only with a doctor's prescription.
- Trial name
- NCT00065871
- Testing
- Contraceptive Screening by Pharmacist, Contraceptive Prescribing by Pharmacist
- Where
- 5 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections
Hormonal Birth Control and the Risk of Acquiring HIV
The purpose of this study is to find out whether hormonal birth control increases, decreases, or does not change the risk of women becoming infected with HIV.
- Trial name
- NCT00006324
- Testing
- Ethinyl estradiol/levonorgestrel, Medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 6,360 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cerebral Perfusion, Contraception
The Effects of the Female Hormones on Cerebral Perfusion
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other…
- Conditions
- Cerebral Perfusion, Contraception, Menstrual Cycle
- Trial name
- NCT03299179
- Testing
- MRI scan, Physiological monitoring, Blood sample
- Where
- Belgium
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Ghent