Clinical trials: Hormone Replacement
Renal Insufficiency, Chronic
Living With Chronic Kidney Disease Without Renal Replacement Therapy: Experience of Women of Childbearing Age
Chronic kidney disease (CKD) affects approximately 13% of the global population. This condition is often associated with comorbidities such as diabetes and hypertension.
- Trial name
- IMAJE (NCT07690202)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Renal Failure
Renal Replacement Therapy in Neonates
The circumstances for setting up dialysis in the neonatal period are multiple: congenital anomaly of the kidney and urinary tract (CAKUT), secondary acute renal failure whose etiologies are multiple (sepsis, hypovolemia…
- Trial name
- Neo-Renal (NCT05456659)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Bietti Crystalline Corneoretinal Dystrophy, Bietti Crystalline Dystrophy
Efficacy and Safety of ZVS101e in Patients With Bietti 's Crystalline Dystrophy
This is a multi-center, randomized and controlled phase 3 clinical trial.
- Trial name
- NCT06743646
- Testing
- ZVS101e
- Where
- 5 sites in China
- Volunteers
- 63 people
- Sponsor
- Chigenovo Co., Ltd
Acute Kidney Injury
Early RRT in AKI After Cardiac Surgery
Acute kidney injury (AKI) is one of the major complications after cardiac surgery that may affects 20% to 40% of patients according to the definitions.
- Trial name
- NCT05175053
- Testing
- Renal replacement therapy, Best medical management
- Where
- 2 sites in South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Renal Injury, Regional Citrate Anticoagulation
Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid.
- Conditions
- Renal Injury, Regional Citrate Anticoagulation, Continuous Renal Replacement Therapy
- Trial name
- NCT06021080
- Testing
- CVVH, CVVHD
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fujian Provincial Hospital
Hyperphosphatemia Patients With Chronic Kidney Disease on 3x/Week Replacement Therapy
Efficacy of SBR759 in Lowering Serum Phosphate Levels in Chronic Kidney Disease Patients on Hemodialysis
This study will evaluate the efficacy of SBR759 compared to sevelamer HCl in lowering serum phosphate levels in Chronic Kidney Disease patients on hemodialysis
- Trial name
- SBR759 (NCT00704483)
- Testing
- SBR759, Sevelamer HCl
- Where
- 66 sites in United States, Australia and 11 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals
Transgender Persons, Hormone Replacement Therapy
Trans & Non-binary Reference Intervals While on Hormone Therapy Study
This study will find out what the reference intervals are for common blood tests in transgender people taking hormone therapy. Reference intervals help doctors interpret blood test results.
- Conditions
- Transgender Persons, Hormone Replacement Therapy, Reference Values
- Trial name
- TransRIHTS (NCT04478760)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Arthralgia, Menopause
The MUSE Study for Menopausal Arthralgia
The investigators plan to conduct a pilot 4-arm, randomized study comprising the following interventions: muscle strengthening exercises (MSE) alone, estrogen therapy (ET) alone, and a combination of MSE and ET, compared to usual…
- Conditions
- Arthralgia, Menopause, Perimenopausal Disorder, Joint Pain
- Trial name
- MUSE (NCT06530459)
- Testing
- Menopausal hormone therapy, Exercise training, Menopausal hormone therapy + exercise training
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Dialysis; Complications, Hemodialysis Complication
Conventional Hemodialysis Versus Post-Dilution Hemofiltration in Incident RRT
Patients with chronic kidney disease (CKD) with criteria for renal replacement therapy (RRT) including uremic syndrome, have a stable state of hyperosmolarity due to urea despite not being an osmotically inactive ion.
- Conditions
- Dialysis; Complications, Hemodialysis Complication, Cerebral Edema, Cognitive Impairment
- Trial name
- DA-VINCI (NCT05060159)
- Testing
- Hemofiltration
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Hypoparathyroidism, Endocrine System Diseases
A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism
This trial has a treatment duration of 78 weeks and will include adult participants already on treatment with palopegteriparatide at doses at or greater than 30 mcg/day.
- Conditions
- Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases
- Trial name
- PaTHway60 (NCT07081997)
- Testing
- Palopegteriparatide Experimental Arm, Palopegteriparatide Control Arm
- Where
- 9 sites in United States
- Volunteers
- 36 people
- Sponsor
- Ascendis Pharma Bone Diseases A/S
Acute Kidney Injury
Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
The aim of the study is to determine whether there is a correlation between changes in the renal resistive index and the restoration of kidney function in critically ill patients undergoing continuous renal replacement therapy.
- Trial name
- NCT06174610
- Testing
- Measurement of Renal Resistive Index
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Acute Renal Failure
Fenoldopam and Acute Renal Failure
Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy. Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in…
- Trial name
- FENO HSR (NCT00621790)
- Testing
- fenoldopam
- Where
- 19 sites in Italy
- Volunteers
- 667 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury (AKI)
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Renal replacement therapy is a life-saving treatment for patients who have sudden and severe kidney failure. However, some of these patients blood pressure who receive this treatment could become unstable, thus resulting in more…
- Trial name
- MitoHIRRT (NCT05264285)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Reproductive Issues
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.
- Trial name
- NCT07388797
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Chinese University of Hong Kong
Nicotine Replacement Therapy
A Study of Blood Levels of Nicotine Following an Electronic Cigarette
The purpose of this study is to assess the amount of nicotine that is absorbed into the blood stream following the use of a new Electronic Cigarette device called the CN electronic cigarette.
- Trial name
- NCT02794220
- Testing
- CN electronic cigarette 10 mg, CN electronic cigarette 15 mg, Nicorette Inhalator 15 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Acute Kidney Failure
Hannover Dialysis Outcome Study
Mortality rates of patients with acute kidney injury in the intensive care unit have changed little over the past few decades despite significant advances in supportive care.
- Trial name
- HAND-OUT (NCT00529139)
- Testing
- Standard extended dialysis, Intensified extended dialysis
- Where
- Germany
- Volunteers
- 157 people
- Sponsor
- Hannover Medical School
Metachromatic Leukodystrophy
Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation
There is currently no effective treatment for late infantile MLD once clinical symptoms are evident. METAZYM is a recombinant human arylsulfatase A developed for an intravenous ERT for the treatment of late infantile MLD.
- Trial name
- Azylis (NCT01303146)
- Testing
- rhARSA
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasomotor Symptoms
A Study of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause
This study is for women in menopause who have moderate to severe hot flashes. It is for women who are unable to use hormone replacement therapy (HRT). Menopause, a normal part of life, is the time after a woman's last period.
- Trial name
- Daylight (NCT05033886)
- Testing
- fezolinetant
- Where
- 69 sites in Belgium, Canada and 14 more
- Volunteers
- 453 people
- Sponsor
- Astellas Pharma Global Development, Inc.
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