Clinical trials: Hormone Replacement
Deep Infiltrating Endometriosis (DIE), Infertility
Ultra-Long GnRH-a Pretreatment for FET Outcomes in Patients With Deep Infiltrating Endometriosis
Deep infiltrating endometriosis is a severe form of endometriosis that may reduce fertility and negatively affect pregnancy outcomes after assisted reproductive treatment.
- Trial name
- DIE-GnRHa-FET (NCT07696351)
- Testing
- Triptorelin (GnRH agonists), Hormone Replacement Therapy (HRT)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li-jun Ding
Menopause, Thrombophilia
Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal Women
The purpose of this study is to determine if Femeralle (DT56a) has an effect on the coagulation system, measured by platelet adhesion and aggregation, of normal and thrombophilic postmenopausal women.
- Trial name
- NCT00883272
- Testing
- DT56a (Femarelle) [Se-cure pharmaceuticals, Dalton, Israel]
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Liver Failure, Acute Kidney Disease
Intraoperative Dialysis in Liver Transplantation
Patient with liver failure waiting for liver transplantation are often hospitalized and commonly supported in an intensive care unit prior to surgery.
- Conditions
- Liver Failure, Acute Kidney Disease, Multi-organ Failure
- Trial name
- INCEPTION (NCT01575015)
- Testing
- Continuous renal replacement therapy (CRRT), Standard intraoperative support
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Endometriosis, Fibroids
Evaluating Tibolone Add-back in Patients With Endometriosis and Fibroids
While there are many medical options for managing endometriosis and fibroids, GnRH-agonist (GnRH-a) therapy remains a very common method of treating these complex conditions.
- Trial name
- eTAPE (NCT05568940)
- Testing
- Tibolone 2.5 Mg Oral Tablet
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HIV Infection, Menopause
Menopausal HT for Women Living With HIV (HoT)
Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV.
- Trial name
- HoT (NCT06856174)
- Testing
- Transdermal estradiol gel, Micronized Progesterone
- Where
- 23 sites in United States
- Volunteers
- 105 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Hypercalciuria, Hypercalciuria, Familial Idiopathic
The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass
The purpose of this study is to assess if estrogen replacement normalizes urinary calcium excretion in postmenopausal women with hypercalciuria and low bone mass and to assess for differences in response to estrogen replacement…
- Conditions
- Hypercalciuria, Hypercalciuria, Familial Idiopathic, Osteopenia, Osteoporosis
- Trial name
- NCT01928082
- Testing
- Transdermal estradiol
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Iron Deficiency Anemia, Coronary Artery Disease
Non-Interventional Study of Ferretab® Comp. (Ferrous Fumarate + Folic Acid Prolonged-Release Capsules) Effects in Adult Patients With Iron Deficiency Anemia and Cardiovascular Disease
The goal of this observational study is to learn how well Ferretab® comp. works and how safe it is for adults with iron deficiency anemia and cardiovascular disease who are receiving treatment as part of their usual medical care.
- Conditions
- Iron Deficiency Anemia, Coronary Artery Disease, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PROMETHEUS (NCT07753031)
- Where
- 5 sites in Russia
- Volunteers
- 389 people
- Sponsor
- Alcea
Obesity
How Gas-Filled Intragastric Balloons or Endoscopic Sleeve Gastroplasty Affect Hunger, Hunger Hormones, and Gastric Emptying Compared to Meal Replacements
The disease obesity continues to be a major health issue in the US with over one third of the population having a mass index >30 kg/m2.
- Trial name
- NCT04306445
- Testing
- GF-IGB: Obalon Balloon, Medically Supervised Meal Replacement Program: My New Weigh, Endoscopic sleeve gastroplasty: (ESG)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Continuous Renal Replacement Therapy
CRRTNet Registry- A Prospective Observational Registry
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury.
- Trial name
- CRRT (NCT02034448)
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- AKI Critical Care Research Foundation
Bariatric Surgery Candidate, Male Hypogonadism
Testosterone in Bariatric Patients
Bariatric surgery is an effective method in the treatment of severe obesity and type 2 diabetes mellitus achieving high remission rates.
- Conditions
- Bariatric Surgery Candidate, Male Hypogonadism, Muscle Loss
- Trial name
- NCT03721497
- Testing
- Testosterone Undecanoate
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Burns, Sepsis
The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
- Trial name
- CRRT (NCT01501097)
- Testing
- Continuous Renal Replacement Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southwest Hospital, China
Premature Ovarian Failure
Evolution of Sexual Life Quality of Women With POI Before and After Introduction of Hormone Replacement Therapy
The aim of this study is to evaluate the evolution of quality of sex life of women with POI after introduction hormone replacement therapy through the FSFI scale
- Trial name
- SEX-POInt (NCT05890417)
- Testing
- questionnaire
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Fabry Disease
Cardiac Involvement in Adult Patients With Fabry Disease; Relation to Enzyme Replacement Therapy
The purpose of this study was to assess the progression of cardiac involvement in adult patients with Fabry Disease (FD), in the unique Danish Fabry cohort and comparing those FD patients receiving primary therapy vs.
- Trial name
- NCT02908724
- Volunteers
- 66 people
- Sponsor
- Ulla Feldt-Rasmussen
Acute Liver Failure
To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial, investigator aim to evaluate the impact of early initiation of CRRT on outcomes in patients with acute liver failure with cerebral edema and hyperammonemia in improving cerebral…
- Trial name
- NCT04991259
- Testing
- Continuous Renal Replacement Therapy (CRRT), Standard Medical Treatment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Fabry Disease
Evaluate the Safety, Pharmacodynamics, Pharmacokinetics, and Exploratory Efficacy of GZ/SAR402671 in Treatment-naïve Adult Male Patients With Fabry Disease
Primary Objective: To assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and exploratory efficacy of GZ/SAR402671 in enzyme replacement therapy treatment-naïve adult male participants diagnosed with Fabry disease.
- Trial name
- NCT02228460
- Testing
- GZ/SAR402671
- Where
- 8 sites in United States, France and 3 more
- Volunteers
- 11 people
- Sponsor
- Genzyme, a Sanofi Company
Menopause
Breast and Vascular Effects of Menopausal Hormone Therapy in Postmenopausal Women
This prospective, single-center, observational controlled cohort study aims to evaluate the effects of menopausal hormone therapy (MHT) on breast imaging findings and carotid intima-media thickness in postmenopausal women.
- Trial name
- BREV-MHT (NCT07810959)
- Testing
- Menopausal Hormone Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Acute Renal Failure, Infection
Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
The purpose of this trial is to study the pharmacokinetics of anidulafungin during continuous venovenous hemofiltration. Background: Anidulafungin is a cyclic lipopeptide antifungal agent of the echinocandin class.
- Trial name
- NCT00892359
- Testing
- Anidulafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hypogonadism
Dose Titration Investigation of the Pharmacokinetics of Testosterone Transdermal Systems in Hypogonadal Men
The study will evaluate the pharmacokinetics of testosterone transdermal systems at steady-state in hypogonadal men.
- Trial name
- NCT01104246
- Testing
- Testerone Transdermal System
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Watson Pharmaceuticals
Mucopolysaccharidosis II
Iduronate-2-sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPS II)
The purpose of this study is to determine whether the administration of iduronate-2-sulfatase enzyme in a weekly or every other week therapy frequency is safe and efficacious in patients with MPS II.
- Trial name
- NCT00069641
- Testing
- Iduronate-2-sulfatase enzyme replacement therapy
- Where
- 9 sites in United States, Brazil and 2 more
- Volunteers
- 96 people
- Sponsor
- Shire
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