Clinical trials: Hormone Replacement
Meibomian Gland Dysfunction
Clinical Efficacy of Hormone Replacement Therapy in Treating Perimenopausal Women With MGD
This project aims to evaluate the possible relationship between MGD and HRT in perimenopausal women
- Trial name
- NCT04962386
- Testing
- Hormone replacement therapy
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Uremic Pruritus, Chronic Kidney Disease-associated Pruritus
Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Several studies investigated the effectiveness of Gabapentin in Uremic Pruritus (UP). No previous studies investigated the use of fexofenadine in UP.
- Conditions
- Uremic Pruritus, Chronic Kidney Disease-associated Pruritus, Hemodialysis, End-stage Renal Disease
- Trial name
- NCT06466421
- Testing
- Fexofenadine, Gabapentin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Acute Kidney Injury
Standard Versus Accelerated Initiation of Dialysis in Acute Kidney Injury
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared with standard…
- Trial name
- STARRT-AKI (NCT01557361)
- Testing
- Accelerated RRT initiation, Standard RRT initiation
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Fabry Disease
A Multicenter Open-Label Treatment Protocol to Observe the Safety of Replagal (Agalsidase Alfa) Enzyme Replacement Therapy in Canadian Patients With Fabry Disease
The purpose of this study is to observe the safety of agalsidase alfa in Canadian patients with Fabry disease.
- Trial name
- NCT01298141
- Testing
- agalsidase alfa
- Where
- 12 sites in Canada
- Volunteers
- 171 people
- Sponsor
- Shire
Primary Immune Deficiency
Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy
The objective of this study is to assess the efficacy, tolerability, safety and pharmacokinetics of IgPro20 in patients with primary humoral immunodeficiency (PID).
- Trial name
- NCT00419341
- Testing
- Human Normal Immunoglobulin for Subcutaneous Administration
- Where
- 13 sites in United States
- Volunteers
- 49 people
- Sponsor
- CSL Behring
End-stage Renal Disease (ESRD), Kidney Disease
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin.
- Trial name
- SAPD (NCT01228279)
- Testing
- DIANEAL, EXTRANEAL
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
End-Stage Kidney Disease, End Stage Renal Disease (ESRD)
Dialysis Efficiency and Transporter Evaluation Computational Tool in Peritoneal Dialysis
The goal of this prospective diagnostic test (correlation) study is to develop and investigate the performance of artificial intelligence in predicting peritoneum transporter status and dialysis efficiency in adult patients…
- Conditions
- End-Stage Kidney Disease, End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis (Diagnosis), End Stage Renal Failure on Dialysis
- Trial name
- DETECT-PD (NCT06842927)
- Testing
- data collection, data report
- Where
- Hong Kong
- Volunteers
- 350 people
- Sponsor
- Tuen Mun Hospital
Smoking, Addiction
Evaluation of Transdermal Nicotine Replacement Therapy (NRT) Activity Through Metabolic Induction
Evaluation to determine if auto-induction can be used as a surrogate measure of nicotine receptor up-regulation through an observational study using nicotine replacement therapy for two weeks and no intervention for two weeks.
- Trial name
- NCT01438944
- Testing
- Nicabate 21mg transdermal NRT
- Where
- Australia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Queen Elizabeth Hospital
Tobacco Use Cessation, Tobacco Use
Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya
People living with HIV (PLHIV) have higher rates of tobacco use than the general population and higher rates of disease and death compared with PLHIV who do not use tobacco.
- Trial name
- NCT05351606
- Testing
- Tobacco Use Cessation Counselling Sessions, Bupropion, Nicotine patch
- Where
- Kenya
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging, Menopause
Estrogen Use in Protection From Cognitive Decline
This study is designed to assess the effects of estrogen therapy among postmenopausal women at risk for cognitive decline.
- Trial name
- NCT00097058
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Kidney Injury
Furosemide Stress Test Guiding Initiation of Renal Replacement Therapy
Does Early Initiation of Renal Replacement Therapy Have an Impact on 7-day Fluid Balance in Critically Ill Patients with Acute Kidney Injury with Positive Furosemide Stress Test?: a Multicenter Randomized Controlled Trial
- Trial name
- NCT02730117
- Testing
- Dialysis with continuous renal replacement therapy, Mechanical ventilator, Anti-Bacterial Agents
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Chulalongkorn University
Turner Syndrome
Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy
Several studies have demonstrated that Turner Syndrome patients have elevated liver enzymes readily suppressible by a short course of HRT.
- Trial name
- NCT00825617
- Testing
- Hormone replacement therapy
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hypogonadotropism
A Dose Ranging Study to Examine TDS-Testosterone 5%
This study is a continuation of previous studies done in healthy volunteers to prove the efficacy of delivering Testosterone, the male hormone, rapidly across intact skin in s series of doses from low to high in men with…
- Trial name
- PARC-T-D (NCT01894308)
- Testing
- Testosterone, Pump Sprayer
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Transdermal Delivery Solutions Corp
Cholesterol Ester Storage Disease(CESD), Lysosomal Acid Lipase Deficiency
Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency
This was the first clinical study of SBC-102 (sebelipase alfa) for the treatment of Lysosomal Acid Lipase (LAL) Deficiency. It was an open-label dose escalation study in adult participants with liver dysfunction due to LAL…
- Conditions
- Cholesterol Ester Storage Disease(CESD), Lysosomal Acid Lipase Deficiency, LAL-Deficiency
- Trial name
- NCT01307098
- Testing
- Sebelipase alfa 0.35 mg/kg, Sebelipase alfa 1 mg/kg, Sebelipase alfa 3 mg/kg
- Where
- 7 sites in United States, Czechia and 2 more
- Volunteers
- 9 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Menopause, Hormone Replacement Therapy
Effects of Hormone Replacement Therapy on Cardiovascular Risk and Body Composition Parameters
Menopause is defined as the last episode of menstrual bleeding, resulting from the interruption of ovarian function by follicular depletion.
- Trial name
- NCT04453332
- Testing
- Oral hormone therapy (estradiol and micronized natural progesterone), Non-oral hormone therapy (estradiol and micronized natural progesterone)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Kidney Injury, Renal Replacement Therapy
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Units
- Trial name
- Taking Focus 2 (NCT03541785)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Renal Replacement Therapy, Mortality
Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal…
- Trial name
- HA-AKI (NCT01151514)
- Testing
- Nephrologist referral
- Where
- Switzerland
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Diffusive and Convective Clearance, Body Clearance
Pharmacokinetics of Piperacillin/Tazobactam in Patients Treated by Continuous Renal Replacement Therapy
The pharmacokinetics of piperacillin/tazobactam will be evaluated in twenty septic patients with renal failure undergoing continuous veno-venous hemodiafiltration.
- Conditions
- Diffusive and Convective Clearance, Body Clearance, Piperacillin Tazocilline Concentrations (Cmin)
- Trial name
- PTCRRT (NCT00703144)
- Testing
- piperacillin/tazobactam, Pharmacokinetic
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Adenocarcinoma of the Pancreas, Normal Pancreatic Exocrine Function
Pancreatic Enzyme Suppletion in Pancreatic Cancer
This study will evaluate the effect of immediate pancreatic enzyme suppletion on the physical and mental health status and survival of patients who are diagnosed with pancreatic cancer and are highly likely to develop exocrine…
- Trial name
- EPC (NCT01401387)
- Testing
- Timing of start treatment with pancreatic enzymes
- Where
- Netherlands
- Sponsor
- Foundation for Liver Research
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