Clinical trials: Hormone Replacement
Obesity, Severe, Pediatric Obesity
Weight Loss With Meal-Replacement Therapy in Teens
This study seeks to examine whether meal-replacement therapy is able to enhance weight loss among teens with severe obesity. In addition, we are also interested in examining the degree of weight loss needed to improve important…
- Trial name
- NCT03137433
- Testing
- Meal-replacement Therapy
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Hormone Replacement
Effects of Hormone Replacement Therapy on the Serotonergic System and Mood in Postmenopausal Women
Menopausal and postmenopausal women compose almost 20% of the Austrian population. Two thirds of all austrian women suffering from depression or anxiety disorders are over 45 years old.
- Trial name
- NCT00755963
- Testing
- estradiol valerate, micronized progesterone
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypogonadism, Male
Vogelxo(R) ABPM Study in Hypogandal Men
A Phase 4 ABPM study in Hypogonadal Men
- Trial name
- NCT04558567
- Testing
- Vogelxo
- Where
- 7 sites in United States
- Volunteers
- 122 people
- Sponsor
- Upsher-Smith Laboratories
HIV Infections
Use of a Test That Evaluates How the Body Handles Insulin and Glucose
The purpose of this study is to find out if testosterone gel affects how the body handles insulin and glucose. Specific anti-HIV treatments may increase a patient's risk of certain diseases by causing metabolic problems such as…
- Trial name
- NCT00027092
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Kidney Injury
Comparison of RCA and RACD in Extra-renal Purification by SLED
One of the main RRT issues is anticoagulation of the ECC, because blood contact with biomaterials causes bio-incompatibility reactions, including activation of the coagulation cascade.
- Trial name
- ARDC-SLED (NCT04968587)
- Testing
- Sustained Low-Efficiency Dialysis
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Groupe Hospitalier Sud Ile-de-France
Hemodialysis
HEMOTOL: Efficacy and Safety of Hemodialysis On-line Monitoring Devices on Hemodynamic Stability in Intensive Care Unit
The purpose of this randomized controlled study is to compare the effects of different new dialysis on-line monitoring devices on hemodynamic stability during intermittent hemodialysis in critically ill patients with acute kidney…
- Trial name
- HEMOTOL (NCT00811109)
- Testing
- Standard Hemodialysis, with Blood Volume Management (BVM®) only, with Blood Volume (BVM®) and Temperature (BTM®) on-line monitoring
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Smoking Cessation, Smoking
Smoking Habits and Smoking Cessation in Young Adults
The purpose of this study is to assess the efficacy and effectiveness of varenicline and nicotine patch combined with motivational interview technique in smoking cessation of young adults over 12 months follow-up.
- Conditions
- Smoking Cessation, Smoking, Habits
- Trial name
- NCT01531049
- Testing
- varenicline, Nicotine cutaneous patch 15mg/16h, Nicotine cutaneous patch 10mg/16h
- Where
- Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tuula Toljamo
Acute Renal Failure
Clearance of Inflammatory Cytokines During Renal Replacement Therapy Using the EMIC®2 Filter
This study will be conducted in patients with sepsis and acute kidney injury needing renal replacement therapy. The aim is to investigate whether continuous renal replacement therapy with the EMIC®2 filter leads to removal of…
- Trial name
- ClicAKI (NCT03231748)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Healthy
Estrogen Alternatives Study
Healthy postmenopausal women not currently taking hormone replacement or hormone modulating therapy take a 3-month course of estradiol/raloxifene/placebo to evaluate the effects of each on vascular function, as indicated by PET…
- Trial name
- NCT00108238
- Testing
- Estradiol followed by progesterone, Raloxifene
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cervical Dysplasia
Smoking Cessation in Women With Gynecological Conditions
This feasibility study will compare two smoking cessation methods, traditional nicotine replacement therapy and Electronic Nicotine Delivery Systems (electronic cigarettes) in patients with gynecological conditions.
- Trial name
- NCT01989923
- Testing
- Nicotine Replacement Therapy, Electronic Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Adrenal Insufficiency
Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.
Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution.
- Trial name
- NCT05457296
- Testing
- Hydrocortisone (capsule)
- Where
- 2 sites in Tunisia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT.
- Trial name
- SAVE (NCT06517810)
- Testing
- QUELIMMUNE (SCD-PED)
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- SeaStar Medical
Amenorrhea, Postmenopause
A Study to Evaluate the Safety and Effectiveness of Asoprisnil and Estrogen Administration to Postmenopausal Women
The objective of this study is to determine the safety and effectiveness of 3 asoprisnil doses when administered to postmenopausal women with Premarin® 0.625 mg.
- Trial name
- NCT00152282
- Testing
- Asoprisnil/Premarin
- Volunteers
- 105 people
- Sponsor
- Abbott
Opioid-use Disorder, Pain, Acute
Acute Pain Management in Patients on Opioid Replacement Therapy
This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in…
- Trial name
- NCT03933865
- Testing
- HYDROmorphone Injectable Solution, Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Smoking Cessation
Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Health Staff
The study is a randomized, controlled trial comparing music therapy associated to NRT versus NRT alone to evaluate the value of music therapy in improving the management of craving among 50 health staff smokers.
- Trial name
- MUSMOKHEALTH (NCT06130423)
- Testing
- Music intervention, Nicotine replacement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Menopause, Hormone Replacement Therapy
Development and Evaluation of a Hormone Replacement Therapy Decision-Aid
The decision regarding the use of post-menopausal estrogen hormone replacement therapy (HT) is complex because patients must balance the short and long-term risks and benefits.
- Trial name
- NCT00012909
- Testing
- Hormone Replacement Therapy Decision-Aid
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
MPS II, Mucopolysaccharidosis II
MPS II Immunophenotyping
The purpose of this study is to investigate how participant's body's immune system responds to idursulfase, an enzyme replacement therapy (ERT) and find out which types of immune cells are involved in causing untoward responses…
- Conditions
- MPS II, Mucopolysaccharidosis II, Hunter Syndrome
- Trial name
- NCT04976231
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Menopause
A Menopause Interactive Decision Aid System
The purpose of this study is to develop and test a web-based system intended to help women going through menopause make more informed choices regarding menopause treatments.
- Trial name
- NCT00345072
- Testing
- Web-based decision aid system
- Where
- 2 sites in United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
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