Clinical trials: Hormone Replacement
Fabry Disease
Safety and Efficacy Study of Several Replagal Dosing Regimens on Cardiac Function in Adults With Fabry Disease
The purpose of this study is to compare the safety and effectiveness of various doses of Replagal in patients with cardiomyopathy due to Fabry disease.
- Trial name
- NCT00864851
- Testing
- Replagal
- Where
- 12 sites in United States, Australia and 6 more
- Volunteers
- 44 people
- Sponsor
- Shire
Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study
What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically…
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT), Filter Clotting, Microbubbles
- Trial name
- NCT07005531
- Testing
- Ultrasound-Guided Microbubble Clearance During Circuit Priming
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Disorders Associated With Peritoneal Dialysis
Study to Evaluate the Effects Icodextrin Versus Dianeal on Insulin Resistance in Nondiabetic Automated Peritoneal Dialysis Patients
1. LOCATION OF STUDY: Multicentric study in Brazil. 2. PURPOSE OF THE STUDY: To measure changes in HOMA index when non-diabetic patients in APD were exposed to 7,5% Icodextrin for the long-dwell; and to compare such changes with…
- Trial name
- STARCH (NCT01021878)
- Testing
- icodextrin, Dianeal
- Where
- 8 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Gaucher Disease
Study of GA-GCB Enzyme Replacement Therapy in Type 1 Gaucher Disease Patients Previously Treated With Imiglucerase
Gaucher disease is a rare lysosomal storage disorder caused by the deficiency of the enzyme glucocerebrosidase (GCB). Due to the deficiency of functional GCB, glucocerebroside accumulates within macrophages leading to cellular…
- Trial name
- NCT00478647
- Testing
- GA-GCB (velaglucerase alfa)
- Where
- 15 sites in United States, Israel and 3 more
- Volunteers
- 40 people
- Sponsor
- Shire
Acute Heart Failure, Congestion
Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure
The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart…
- Conditions
- Acute Heart Failure, Congestion, Heart Failure
- Trial name
- SOLVRED-AHF (NCT05962255)
- Testing
- Furosemide intravenous infusion, Continous intravenous infusion of 0.9% Sodium Chloride solution, Continous intravenous infusion of 5% Glucose solution
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Wroclaw Medical University
Peritoneal Dialysis, Hemodialysis, Home
Experiences and Health-related Quality of Life of Informal Caregivers of Dialysis Patients
The goal of this prospective, observational, multicentre cohort study is to assess the trajectory of the experiences (both positive and negative) and health-related quality of life (HRQOL) of informal caregivers of patients who…
- Conditions
- Peritoneal Dialysis, Hemodialysis, Home, Hemodialysis, Quality of Life
- Trial name
- NCT05646615
- Where
- 33 sites in Belgium, Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- B.C. van Jaarsveld
Nicotine Addiction
Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy
A pragmatic, single blinded, randomized, controlled non-inferiority trial of Cytisine versus Nicotine Replacement Therapy for continuous abstinence is conducted in the government run primary health hospitals in Mongolia.
- Trial name
- NCT04126135
- Testing
- Cytisine, Nicotine Replacement Therapy (NRT)
- Where
- Mongolia
- Volunteers
- 1,307 people
- Sponsor
- Loma Linda University
Fabry Disease
Replagal Enzyme Replacement Therapy for Children With Fabry Disease
Primary Objective(s): To assess the safety of Replagal at a dose of 0.2 mg/kg administered over 40 (+/-10) minutes in children with Fabry disease To assess the effect of Replagal on heart rate variability in patients 7 to 17…
- Trial name
- NCT00084084
- Testing
- Agalsidase alfa
- Where
- 14 sites in United States, Canada
- Volunteers
- 17 people
- Sponsor
- Shire
Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill…
- Conditions
- Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency, Myocardial Stunning
- Trial name
- MS-CRRT (NCT05209230)
- Testing
- Continuous renal replacement therapy, Control group
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Acute Lung Injury, Acute Kidney Injury
Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy
Objective of the study is to assess the safety and efficacy of CO2 removal by the multiECCO2R (CO2 Removal System) on the multiFiltrate/multiFiltrate Pro in veno-venous extracorporeal circulation during continuous renal…
- Conditions
- Acute Lung Injury, Acute Kidney Injury, Hypercapnia, Covid19
- Trial name
- multiECCO2R (NCT04871893)
- Testing
- multiECCO2R blood-gas exchanger
- Where
- 6 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Congenital Bleeding Disorder, Congenital FXIII Deficiency
Safety and Efficacy of Monthly Replacement Therapy With Recombinant Factor XIII (rFXIII) in Paediatric Subjects With Congenital Factor XIII A-subunit Deficiency
This trial will be conducted in Asia, Europe and the United States of America (USA). The aim of this clinical trial is to investigate long-term safety of rFXIII when administered for prevention of bleeding episodes in children…
- Trial name
- mentor™5 (NCT01253811)
- Testing
- catridecacog
- Where
- 4 sites in United States, Israel and 1 more
- Volunteers
- 6 people
- Sponsor
- Novo Nordisk A/S
Hypoleptinemia, Generalized Lipodystrophy
Trial of Leptin Replacement Therapy in Patients With Lipodystrophy
Lipodystrophies represent a therapeutic challenge with regards to insulin resistance, hypertriglyceridemia and fatty liver which often is coupled with significant adipose tissue loss.
- Conditions
- Hypoleptinemia, Generalized Lipodystrophy, Partial Lipodystrophy, Insulin Resistance
- Trial name
- NCT00896298
- Testing
- Leptin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Alzheimer Disease
Alzheimer's Disease: Therapeutic Potential of Estrogen
This is a 15-month study to determine the effectiveness of hormone replacement therapy in improving memory and the ability to live independently in postmenopausal women with Alzheimer's disease.
- Trial name
- NCT00066157
- Testing
- Transdermal estradiol, Medroxyprogesterone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Wisconsin, Madison
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Panhypopituitarism
Testosterone Gel Applied to Women With Pituitary Gland Problems
The principal aim of this study is to evaluate if application of testosterone gel leads to improvement in measures of sexual function, thinking ability and quality of life in women with dysfunction of the pituitary gland.
- Trial name
- NCT00144391
- Testing
- Transdermal Testosterone gel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Acute Kidney Injury, Hemorrhage
Efficacy and Safety of Heparin-grafted Membrane for CRRT
The investigators hypothesize that the use of heparin-grafted membrane versus conventional membrane in critically-ill patients with bleeding-risk undergoing continuous renal replacement therapy, will effectively prolong the…
- Conditions
- Acute Kidney Injury, Hemorrhage, Coagulopathy
- Trial name
- CARROM (NCT01779635)
- Testing
- oXiris as first filter, M150 as first filter
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Smoking Cessation, Second Hand Tobacco Smoke
The "Quit-for-Kids" Project: to Increase Abstinence and Protect Children From Tobacco Smoke Exposure
This project aims to test the effectiveness of an integrated intervention of brief cessation advice (AWARD), Nicotine Replacement Therapy, and Instant Messaging support compared with waitlist control participants among adult…
- Trial name
- NCT06127589
- Testing
- Brief cessation advice (AWARD), Nicotine Replacement Therapy (NRT), Instant messaging Support (IM)
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Acute Kidney Injury
Pharmacokinetics of Vancomycin in the ICU in Renal Replacement Therapy
This study is an observational analysis that monitors the effect of different dialysis methods on vancomycin levels when patients are critically ill.
- Trial name
- NCT00848809
- Testing
- Blood sample
- Where
- United States
- Sponsor
- Avera McKennan Hospital & University Health Center
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