Clinical trials: Hospitalized COVID-19
COVID-19
Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
This randomized study evaluates the antiviral activity, safety, efficacy and pharmacokinetics of AT-527 versus a placebo in participants with mild or moderate coronavirus disease (COVID-19) who are not hospitalized.
- Trial name
- NCT04709835
- Testing
- AT-527
- Where
- 12 sites in Canada, Greece and 4 more
- Volunteers
- 104 people
- Sponsor
- Hoffmann-La Roche
Covid19
Evaluation of the Impact of Hospitalization in Intensive Care for COVID-19 Infection
To evaluate the psychological, physical, social, professional and family impact of a hospitalization in intensive care for a covid 19 by analysis of the verbatim during a semi-structured interview.
- Trial name
- POSTREACOVID (NCT04849585)
- Testing
- semi-directed entretien
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Tourcoing Hospital
Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome
Metformin Glycinate in Patients With MS or DM2 , Hospitalized With COVID-19 and SARS Secondary to SARS-CoV-2
The purpose of this study is to evaluate the efficacy and safety of metformin glycinate at dose of 620 mg twice per day plus standard treatment comparing to standard treatment alone (we will use placebo) of patients who have…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome, Type 2 Diabetes
- Trial name
- DMMETCOV19 (NCT04626089)
- Testing
- metformin glycinate
- Where
- Mexico
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Covid-19, Corona Virus Infection
Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19
Introduction There are currently no treatments with demonstrated efficacy for COVID-19 infection. Epidemiological evidence points to the existence of intrinsic protection factors which make young persons and women more resistant…
- Conditions
- Covid-19, Corona Virus Infection, SARS-CoV 2
- Trial name
- OsCOVID19 (NCT04386447)
- Testing
- Oxytocin, Standard of Care
- Where
- 3 sites in France, Italy
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
COVID-19
Disability Following Hospitalization in People of Working-age Surviving SARS-CoV-2 Infection - COVID-19
The purpose of the study is to describe disability following hospitalization in people of working-age surviving COVID-19.
- Trial name
- DisCOVID (NCT04724395)
- Testing
- Hospitalization
- Where
- France
- Volunteers
- 530 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Pneumonia
Investigating the Efficacy and Safety ICATIBANT For The Treatment of Patients With SARS-CoV-2 (COVID-19) Infection
To study the efficacy and safety of icatibant in adult patients admitted to hospitalization units for pneumonia caused by COVID-19, without mechanical ventilation, 10±1 days after starting treatment or discharge from hospital if…
- Trial name
- ICAT·COVID (NCT04978051)
- Testing
- Firazyr, SoC
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Sebastian Videla
the Prognostic Value of Ferritin, Glycosylated Ferritin in SARS-CoV-2 Infection in Hospitalized COVID-19 Patients
Interest of the Dosage of Ferritin / Glycosylated Ferritin in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus responsible for the pandemic called coronavirus disease 2019 (COVID-19), which appeared in China in December 2019 and which has spread rapidly…
- Trial name
- NCT04469153
- Testing
- No intervention / Evaluation of the ferritin and glycosylated ferritin by standard approved serological tests
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Hospices Civils de Lyon
COVID-19
A Study to Evaluate the Safety and Efficacy of OT-101+Artemisinin in Hospitalized COVID-19 Subjects
Primary Objective is to evaluate the safety and efficacy of OT-101+Artemisinin when used in combination with standard of care (SoC) in hospitalized COVID 19 subjects versus SoC+ Artemisinin+Placebo.
- Trial name
- NCT04801017
- Testing
- OT-101, Artemisinin
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Oncotelic Inc.
COVID-19, Azvudine
The Real-world Clinical Study of Azvudine Tablets in the Treatment of COVID-19
To establish a real-world clinical cohort and database of Azvudine in the treatment of SARS-CoV-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment…
- Trial name
- NCT06349655
- Testing
- Azvudine, Paxlovid
- Where
- China
- Volunteers
- 32,864 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
SARS-CoV-2 Infection
A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized
The purpose of the study is to understand the effects and safety of PF-07817883 treatment. The study wants to know how PF-07817883 treatment lowers the level of the virus that causes COVID 19.
- Trial name
- NCT05799495
- Testing
- PF-07817883
- Where
- 53 sites in United States
- Volunteers
- 240 people
- Sponsor
- Pfizer
COVID-19 Infection
CRISIS2: A Phase 2 Study of the Safety and Antiviral Activity of Brequinar in Non-hospitalized Pts With COVID-19
This study will assess the efficacy and safety of DHODHi (brequinar) as an antiviral via 5 days of treatment of participants with positive COVID-19 and at least one symptom of COVI019 in an out-patient setting.
- Trial name
- CRISIS2 (NCT04575038)
- Testing
- Brequinar
- Where
- 14 sites in United States
- Volunteers
- 115 people
- Sponsor
- Clear Creek Bio, Inc.
COVID-19
ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19
This is a platform trial to conduct a series of randomized, double-blind, placebo-controlled trials using common assessments and endpoints in hospitalized adults diagnosed with COVID-19.
- Trial name
- NCT04988035
- Testing
- Danicopan, Remdesivir
- Where
- 39 sites in United States
- Volunteers
- 201 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19
Impact of Vaccination in Acute COVID-19
The aim of this study was to evaluate the association between vaccination with one of the four SARS-CoV-2 vaccines authorized for use in the European Union-BNT162b2, ChAdOx-1S, mRNA-1273 or Ad.26.COV2.S-and progression to…
- Trial name
- NCT05198453
- Testing
- vaccination
- Where
- Slovenia
- Volunteers
- 529 people
- Sponsor
- University Medical Centre Ljubljana
COVID-19 Infection, Thyroid Function Tests
Thyroid Function Tests and Status of Thyroid Autoantibodies in Covid-19 Patients
COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation through cytokines in various organs of the body, especially the lungs.
- Conditions
- COVID-19 Infection, Thyroid Function Tests, Inflammation; Thyroid, Inflammatory Markers
- Trial name
- NCT04659200
- Testing
- Venous blood was collected for biochemistry testing.
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
COVID-19
A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients
This study is a randomized, open label clinical trial to evaluate the safety and efficacy of hydroxychloroquine (HCQ) plus usual care compared to usual care in approximately 350 hospitalized patients diagnosed with COVID-19.
- Trial name
- OAHU-COVID19 (NCT04345692)
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Queen's Medical Center
Covid19
Coronavirus Disease (COvid-)19 REgistry on THROMBOSIS Complications
This online-based, observational retrospective registry aims to (i) study the rate of cardiovascular events, encompassing venous thromboembolic and arterial events, in consecutive hospitalized patients with coronavirus (Covid19)…
- Trial name
- CORE-THROMB (NCT04780295)
- Where
- 30 sites in Brazil, Denmark and 6 more
- Volunteers
- 2,708 people
- Sponsor
- Johannes Gutenberg University Mainz
Covid19, Vitamin D
Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19
Open controlled clinical trial. Hospitalized pediatric patients with COVID-19 will be included. Upon admission to hospital serum determination of vitamin D, interleukins, ferritin and Dimer D will be performed.
- Conditions
- Covid19, Vitamin D, Children, Only
- Trial name
- COVID-19 (NCT04502667)
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Covid19, Venous Thromboembolism
Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial
The Michelle trial is expected to provide high-quality evidence around the role of extended thromboprophylaxis in COVID-19 and will help guide medical decisions in clinical practice.
- Trial name
- MICHELLE (NCT04662684)
- Testing
- Rivaroxaban 10 MG
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Science Valley Research Institute
COVID-19
Study of the Use of Favipiravir in Hospitalized Subjects With COVID-19
To determine the effect of favipiravir + SOC v. SOC on COVID-19 viral clearance.
- Trial name
- NCT04358549
- Testing
- Favipiravir, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Fujifilm Pharmaceuticals U.S.A., Inc.
COVID -19
C Reactive Protein in Home Quarantined Coronavirus Disease 2019 (COVID -19) Patients.
During the peak of the second COVID -19 wave, the hospitals were over-crowded. Many COVID -19 positive patients had to stay at home and reach out to their family physicians for guidance.
- Trial name
- NCT04935515
- Testing
- Oral Antibiotic, Antihistamine, Anti-inflammatory, Multivitamins, Oral low dose steroid, Intravenous Antibiotics with Low dose steroid.
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Manimarane Arjunan, MD,DM (Cardiology)