Clinical trials: Hot Flashes
Vasomotor Symptoms, Endometrial Safety
Study of Hot Flashes and Night Sweats in Postmenopausal Women Receiving Combination Raloxifene and Oral Estrogen
This pilot study was designed to explore the effects of combined treatment with raloxifene HCl 60 mg and oral 17 beta-estradiol 1mg/day on the number of vasomotor episodes (hot flashes plus night sweats) in postmenopausal women…
- Trial name
- NCT00332553
- Testing
- Raloxifene, medroxyprogesterone acetate, estrogen
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hot Flashes
Soy Isoflavone Tablets: Effects on Sleep, Quality of Life, Symptoms and Cognitive Function in Menopausal Women
The study was done to elucidate relationships between midlife women's self-reported hot flashes, neuropsychological symptoms, cognitive performance or sleep.
- Trial name
- NCT01401946
- Testing
- soy isoflavones
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hot Flashes
Womens Study to Alleviate Vasomotor Symptoms
This study tests the hypothesis that a low-fat, vegan diet including soybeans reduces the frequency and severity of menopausal hot flashes, and tests the hypothesis that total isoflavone intake is associated with the reduction in…
- Trial name
- WAVS (NCT04587154)
- Testing
- low-fat vegan diet with 1/2 cup soybeans daily
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Hot Flashes
Gabapentin Versus Estrogen for the Treatment of Hot Flashes
To compare the efficacy and safety of gabapentin, estrogen and placebo in the treatment of hot flashes and other climacteric symptoms.
- Trial name
- NCT00276081
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hot Flashes
Hypnosis For Hot Flashes Among Postmenopausal Women in a Randomized Clinical Trial
This study is designed to determine the effect of a Hypnosis Intervention on reducing hot flash frequency (perceived impact vs. physiologically measured impact), severity and daily interference in post-menopausal women.
- Trial name
- NCT01293695
- Testing
- Hypnosis, Structured attention
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Baylor University
Hot Flashes, Menopause
Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes
This study is being done to determine whether stellate ganglion injection with local anesthetic (the study procedure) can reduce the number and severity of hot flashes in women who have hot flashes.
- Trial name
- NCT00992914
- Testing
- Sympathetic nerve block with 1% lidocaine 1-2 ml, Superficial subcutaneous injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sleep
Hypnosis to Improve Sleep In Menopause
The purpose of this study is to determine feasibility and adherence to a hypnosis program to improve sleep. It is theorized (based on prior experience and pilot data) that one or more hypnosis program(s) will be feasible and will…
- Trial name
- NCT02187419
- Testing
- Hypnosis
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Baylor University
Breast Cancer
Study Evaluating Hot Flashes in Hormone Sensitive Breast Cancer
The validation of the HFRDIS questionnaire in French will allow the use in common practice of this questionnaire in consultation in order to have a concrete and reproducible assessment of the impact of hot flashes on the daily…
- Trial name
- HOTSHOT (NCT04775043)
- Testing
- HFRDIS questionnaire completion
- Where
- France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Hot Flashes, Sleep
LINE-1 and Alu Methylation Levels Among Middle Aged Women With Low Cardiovascular Risk Profile in Respect of Menopausal Hot Flashes
Vasomotor symptoms are the most common symptoms seen during climacterium. The hypoestrogenic state causes dysfunction of hypothalamic preoptic area, a thermoregulatory center.
- Conditions
- Hot Flashes, Sleep, Menopause, Cardiovascular Diseases
- Trial name
- NCT05892211
- Testing
- Polysomnography, Skin conductance, ALU and LINE-1 DNA methylation analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Breast Cancer
Whole Body Vibration Training and Breast Cancer Risk Factors
study aim is to determine the effect of whole body vibration training (WBVT) on body mass index, serum prolactin concentration as a risk factors for breast cancer and severity of hot flashes in obese postmenopausal women.
- Trial name
- NCT04708093
- Testing
- whole body vibration training
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Menopause, Hot Flashes
The Effect of Extended-Release Oxybutynin Chloride on Vasomotor Symptoms in Healthy Post-Menopausal Women
The objective of this study is to evaluate the safety and efficacy of extended-release oxybutynin chloride for the treatment of vasomotor symptoms, also known as hot flashes, in healthy naturally postmenopausal women.
- Trial name
- NCT00990886
- Testing
- Oxybutynin chloride
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Major Depressive Disorder, Insomnia
Quetiapine Extended Release (XR) for the Treatment of Menopausal Depression
The study was designed to examine the efficacy and tolerability of quetiapine XR for the treatment of women who suffer from depression in the context of the menopausal transition and postmenopausal years.
- Conditions
- Major Depressive Disorder, Insomnia, Hot Flashes
- Trial name
- NCT00723970
- Testing
- Quetiapine Extended Release
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Menopause
Single-Dose Study of Black Cohosh and Red Clover
This Phase I study will assess the pharmacokinetics of two botanicals, Trifolium pratense (red clover) and Cimicifuga racemosa (black cohosh). Participants will receive a single dose of one botanical preparation.
- Trial name
- NCT00010959
- Testing
- Cimicifuga racemosa, Trifolium pratense
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hot Flashes, Hot Flushes
Stellate Ganglion Blockade in Post-Menopausal Women
Hot flashes and night sweats (vasomotor symptoms, VMS) affect 80% of women during the menopausal transition (MT). VMS are associated with decreased quality of life, increased depressive and anxiety symptoms, memory complaints…
- Conditions
- Hot Flashes, Hot Flushes, Vasomotor Symptoms
- Trial name
- R01 (NCT02907983)
- Testing
- Stellate Ganglion Block Injection with Bupivicaine, Saline injection
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Risk Reduction, Breast Cancer
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens
Women at risk for development of breast cancer and experiencing vasomotor menopausal symptoms (hot flashes) will be randomized to bazedoxifene (BZA) plus conjugated estrogens (CE) for 6 months versus a wait list control.
- Trial name
- NCT04821141
- Testing
- Bazedoxifene and Conjugated Estrogens
- Where
- 6 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hot Flushes, Menopause, Premature
The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition
Specific Aim 1: To compare effects of Vitamin D supplementation to usual care on symptoms in women transitioning to early postmenopause and determine the associated effect size in order to conduct a power analysis for a future…
- Conditions
- Hot Flushes, Menopause, Premature, Obesity, Vitamin D Deficiency
- Trial name
- FLASH (NCT01141972)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Vasomotor Symptoms
Goji Berry and Vasomotor Symptoms Pilot Study
The goal of this clinical trial is to compare two forms of goji berry powder-whole goji berry powder and goji juice powder-in peri- and postmenopausal women aged 40-65 years who experience frequent vasomotor symptoms (hot…
- Trial name
- GOJI-VMS (NCT07660315)
- Testing
- Goji Berry Juice Powder, Goji Berry Powder
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Hot Flushes
E4Relief (Response to Estetrol in Life Improvement for MEnopausal-associated Hot Flushes)
This dose-finding study is being conducted to select the daily oral dose of estetrol (E4) for the treatment of vasomotor symptoms (VMS) in post-menopausal women.
- Trial name
- NCT02834312
- Testing
- Estetrol
- Where
- Belgium
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Donesta Bioscience
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research